Sentences with phrase «as transcription factors»

Unlike most proteins, those with these special domains can actually bind to DNA and act as transcription factors — telling specific genes to turn on or off.

The lab has been developing computational methods and tools to allow researchers and clinicians to identify functional consequences of genetic variations within cis - regulatory elements such as transcription factor binding sites.

Using a technique known as transcription factor reprogramming, first described by the Japanese stem - cell pioneer Shinya Yamanaka and his colleagues in 2007, Ku «rebooted» the skin cells» genetic machinery to turn them into stem cells.

Here, we have shown for the first time that the unphosphorylated STAT2 could play an important role in RIG - G gene expression by interacting with IRF - 9, further reinforcing the idea that STAT proteins could function as transcription factors in the absence of tyrosine phosphorylation.

hGDAsCNTF also expressed high levels of neurite - outgrowth inhibitory chondroitin sulfate proteoglycans, phosphacan and CSPG4, as well as the transcription factor Olig2 - all of which have been found to be upregulated in glial scar associated astrocytes.

Taken together, these data support the hypothesis that PRDM16 is present and functional as a transcription factor in the nuclei of cardiomyocytes in the embryonic and adult mammalian left ventricular myocardium.

ALFA compiles the current state - of - art about the annotations of DNA regulatory elements (such as transcription factor binding sites, microRNA target sites) for a better understanding of biological processes underlying rare diseases.

In all the pathways so far investigated, the final result is a gradient of morphogen that functions principally as a transcription factor, initiating or suppressing the transcription of one or more target genes in a concentration - dependent manner.

Silver and her team constructed two new genes that would code for two artificial proteins designed to behave as transcription factors (proteins that control the amount of other proteins that a particular gene can make.)

Because STAT2 is the only member of the STAT family without DNA - binding activity, it can act as a transcription factor only when complexed to other STATs or proteins (31).

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

Currently, enhancers can be identified through chromatin - based assays, such as ChIP - seq, which predict enhancer elements indirectly based on the enhancer's association with specific epigenomic marks, such as transcription factors or molecular tags on DNA - associated histone proteins.

The MYC protein acts as a transcription factor that governs the expression of many important genes.

In addition, when these transcription factors lose their function, terminal differentiation into the vascular endothelium (completion of differentiation) is completely suppressed, and genes that are key to differentiation into vascular endothelial cells as well as transcription factors that maintain the undifferentiated state are adversely induced.

They later showed that RORA, a nuclear hormone receptor that functions as a transcription factor, can potentially regulate the transcription of more than 2,500 genes, including over 400 genes already associated with autism.

When, where and how proteins are expressed is determined by regulatory DNA sequences and a group of proteins, known as transcription factors, that bind to these DNA sequences.

Abnormal and uncontrolled production of this class of proteins, known as transcription factors, allow for cells to bypass growth control mechanisms and to develop characteristics necessary for invading surrounding tissues.

The proteins that regulate which genes are expressed are known as transcription factors (TFs).

«We now have a long - awaited base model where new higher level regulatory factors, such as transcription factors (regulatory proteins), regulatory RNAs and others important to growth and adaptation, can be incorporated to continuously improve the predictability and extend the application of the model,» says Chiang, longtime leader of the Forest Biotechnology Group.

Together, the discovery of such rapid dynamic modes within chromatin fibers provides new insight how processes can gain access to the DNA (or are prevented to do so), such as transcription factors, or the machinery for transcription, replication or DNA repair.

This variation of the distinct cell types comes from the differential expression of genes, which is controlled by interplay between different regulators within the cells, such as transcription factors, the transcription machinery, and the «epigenetic» modifications (which do not change the underlying genetic code) that occur on the DNA and protein factors within chromatin.

Focusing on two proteins known as transcription factors, the researchers showed that genetically removing the two transcription factors, Tcf1 and Lef1, in mice is sufficient to prevent leukemia stem cells from persisting.

Are there new technologies to inhibit traditionally «undruggable» target molecules, such as transcription factors, that are required for the oncogenic phenotype?

Turns out, ApoE4 may function as a transcription factor, according to a study published today (January 20) in the The Journal of Neuroscience, led by investigators at the Buck Institute for Aging Research and the University of California, Los Angeles (UCLA).

The MYC protein acts as a transcription factor that governs the expression of many -LSB-...]

ChIP - Seq is a powerful tool to study genetic regulation, because it enables one to accurately identify regions of DNA bound by specific proteins, such as transcription factors or RNA Polymerase II components.

In contrast, many scientists consider that chromatin does not form an independent epigenetic layer of the genome and that chromatin modifiers do not operate independently of a DNA sequence specific targeting mechanism, such as transcription factors.

Proteins that control gene activity (known as transcription factors) play a key role in this process, which the 4D Genome team studied in great detail, assessing how they induce changes in gene expression, modifications of chromatin (the structure around which DNA is wrapped), and changes in the 3D organisation of the genome.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

As a transcription factor, p53 protein can be covalently modified by different enzymes.

[8] The binding of calcitriol to the VDR allows the VDR to act as a transcription factor that modulates the gene expression of transport proteins (such as TRPV6 and calbindin), which are involved in calcium absorption in the intestine.

The vitamin A — RXR - alpha complex «dimerizes» with these other nuclear receptors, forming a new complex that acts as a transcription factor to turn on gene expression.