Sentences with phrase «cancer cell invasion»

Here we show that an abundant stromal cell population, cancer - associated fibroblasts (CAFs), promote cancer cell invasion through the BM.

By screening already approved drugs, the team led by Postdoctoral Researcher Guillaume Jacquemet and Academy Professor Johanna Ivaska has discovered that calcium channel blockers can efficiently stop cancer cell invasion in vitro.

Thus, in a panel of breast cancer samples, we identified tumor cells that did not form part of the bulk tumor mass, but instead were interspersed within the adjacent stroma — as if forming the forefront of cancer cell invasion.

A study in The Journal of Cell Biology uncovers one way that p53 acts to prevent cancer cell invasion.

A team led by Hisataka Sabe at Hokkaido University Graduate School of Medicine in Sapporo, Japan, suspected that the MVP might promote invasiveness by activating the Arf6 signaling pathway, which enhances cancer cell invasion and metastasis by promoting the cells» transition to a more motile state.

ABL kinases regulate cancer cell invasion (21), but it is unclear whether they play a role in the regulation of subsequent steps of the metastatic cascade.

However, it remains unclear whether CAFs directly stimulate cancer cell invasion or they remodel the extracellular matrix to make it more permissive for invasion.

By exerting contractile forces, CAFs alter the organization and the physical properties of the BM, making it permissive for cancer cell invasion.

Here the authors, using an ex-vivo model, show that cancer - associated fibroblasts facilitate colon cancer cells invasion in a matrix metalloproteinase - independent manner, likely by pulling and stretching the basement membrane to form gaps.

The tumor microenvironment provides a niche that supports cancer cell invasion and proliferation.

Her project aims to identify more placental RDGs and determine whether they are also activated in cancer cells, and if so, whether they promote cancer cell invasion.

Dr. Beauchamp's primary area of research interest has been in colorectal carcinogenesis, the biology of cancer cell invasion and metastasis, and in the identification of novel molecular biomarkers and therapeutic targets in colorectal and other alimentary tract malignancies.

The researchers used a drug called clorgyline to inhibit the activity of the MAOA enzyme; the drug disrupted the signaling system that led to cancer cell invasion and proliferation.

The phenomenon of collective cell migration has been observed in the process of animal development, the healing of wounds, and cancer cell invasion.

Thanks to the activity of the mevalonate pathway, Rab11b delivers Arf6 (green) to the plasma membrane, where it can be activated to promote cancer cell invasion and drug resistance.

According to the researchers, these findings suggest that differences in shape from cell - to - cell within a tissue are key to their ability to jam and unjam — and that this process appears to drive biological events including embryonic development, wound healing, and, potentially, cancer cell invasion.

«The plasma membrane also dynamically changes shape during cell migration, cancer cell invasion, cell division, nutrient uptake, and entry of pathogens and viruses into cells,» Shin explains.

ABL kinases elicit protumorigenic or antitumorigenic effects in breast cancer cells and promote cancer cell invasion (7 — 10).

Studies on Caenorhabditis elegans, leucocytes diapedesis and cancer cell invasion have shown that BM transmigration is a conserved three - stage process.

EMT works hand - in - glove with MMPs, or matrix metalloproteases, which also play an essential role in cancer cell invasion and metastasis.