Sentences with phrase «cancer cell lines»

Using human cancer cell lines helps, but the crucial interplay between the cancers and their host environments is absent.

Historically, a potential therapeutic compound would be tested on cancer cell lines to validate the functional efficacy of the compound.

Six of these compounds were active in a dose - response relationship in three distinct ovarian cancer cell lines.

The drug resulted in greater than 80 percent decrease in growth of adrenal cancer cell lines as well as inhibition of tumor growth in animal models.

The researchers tested the drug combinations against four different human cervical cancer cell lines.

All four cancer cell lines responded significantly to radiation plus the three - drug combination.

And when the team analyzed the gene expression profiles of the surviving cancer cell line, they were again surprised.

To assess the ability of F3 - IgG to inhibit the proliferation of HER2 - overexpressing breast carcinoma cells, we measured the proliferation of BT474, MCF7 / HER2 and MCF7 breast cancer cell lines in the presence of trastuzumab, F3 - IgG, or an isotype - matched control antibody.

I have worked in cytogenetics in a research looking at the percentage of micronuclei in exfoliated cells in urine of Bilharzia pateints this was a while ago but recently I have been working with prostate cancer cell lines in a project to develop m...

Working with mouse prostate cancer cell lines in the laboratory, the investigators found that cells containing overexpressed TOP2A and EZH2 genes were highly sensitive to attack with a combination of two drugs.

Treatment of lung cancer cell lines with mebendazole caused mitotic arrest by depolymerization of tubulin, followed by apoptotic cell death.

Using a new TaqMan PCR - based technique, the researchers screened a number of cancer cell lines from various tissues, and discovered that tRNA halves were specifically expressed in large quantities in sex hormone - dependent cancers, i.e., estrogen receptor (ER)- positive breast cancer and androgen receptor (AR)- positive prostate cancer that are driven by the hormones estrogen and testosterone.

When Possemato suppressed PHGDH protein production in breast cancer cell lines with elevated levels of it, the cells stopped proliferating.

Researchers at the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, tested the impact of grape seed extract in colorectal cancer cell lines at several stages of the disease.

Ab7291 staining alpha tubulin in human breast cancer cell line by ICC / IF (Immunocytochemistry / Immunofluorescence).

Given their similar profiles, Seyedsayamdost and coworkers hypothesized that TDA might exhibit anticancer properties as well, and indeed observed its strong anticancer activity in a screen against 60 different cancer cell lines.

During lab testing, the compound «markedly inhibited» the growth of three human pancreatic cancer cell lines five days after treatment and induced the death of pancreatic cancer cells.

A University of Colorado Cancer Center study published in the journal Oncogene used next - generation sequencing technologies to perform the most detailed DNA - based analysis to date of 25 commonly used bladder cancer cell lines, allowing researchers to match patient tumors with their closest genetic cell line match, and demonstrated genetic alterations that may make cells more or less sensitive to common therapies.

No cytotoxicity was observed on gastric cancer cell lines lacking Gb3 expression, demonstrating receptor specificity of the STxB - SN38 compound.

The functional data provided from a limited series of breast cancer cell lines does not allow generalizable conclusions to be drawn.

«Canine cancer cell lines for research and drug development.»

Ellagic acid has been shown to induce apoptosis in prostate and other cancer cell lines within 48 hours.

The current study was based on previous studies in the laboratory of Nita Ahuja, M.D., director of the Sarcoma and Peritoneal Surface Malignancy Program and professor of surgery at the Johns Hopkins University School of Medicine, which showed that guadecitabine limited the growth of colorectal cancer cell lines when combined with irinotecan, says Azad.

Members of the University of Colorado Cancer Center from the Flint Animal Cancer Center (FACC) at Colorado State University report at the American Association for Cancer Research (AACR) Annual Meeting 2015 the assembly of a panel of validated canine cancer cell lines named the FACC - 29, analogous to the NCI - 60.

The human prostate cancer cell line PC3, which was obtained from Scott Crist (Purdue University), was maintained in Roswell Park Memorial Institute - 1640 (RPMI - 1640) medium, containing 10 % fetal bovine serum, FBS (HyClone), and 1 % penicillin / streptomycin plus L - glutamine.

They infected a non-small cell lung cancer cell line containing an activating mutation in epidermal growth factor receptor (EGFR) with the ClonTracer library and monitored population dynamics after treatment with EGFR inhibitor, erlotinib.

The authors administered NK cells via intraperitoneal injection into a xenograft mouse model established using bioluminescent ovarian cancer cell lines which allow for tumor monitoring via bioluminescent imaging (BLI).

This study defined about 200 negative genetic interactions in the isogenic cancer cell line background.

Grape seed extract has shown some promise in a number of laboratories looking at cancer cell lines.

Using two cancer cell lines differing only in the integrity of p53 gene, the scientists observed that cancer cells with defective p53 had much less MHC class I on the cell surface.

Of great interest, stem - like cells have also been discovered in some cultured cancer cell lines, including glioma (22, 23), ovarian (24, 25), liver (26), and prostate (27 — 29) cancer cells.

Researchers in the UNC School of Medicine found that the protein DAZAP1 plays a key role in the regulation of many genes through a process known as alternative splicing, and when highly expressed in cancer cell line experiments, DAZAP1 was shown to inhibit several types of cancer cells from dividing and moving.

Using genetic techniques to knock out PBK slowed the growth of the group's adrenal cancer cell lines.

Diverse signaling pathways through the SDF - 1 / CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis.

Hon et al created a low - passage cancer cell line using a Her2 + ER - / PR - tumor from an East Indian female.

«The extracts from cruciferous vegetables as well as those from vegetables of the genus Allium inhibited the proliferation of all tested cancer cell lines whereas extracts from vegetables most commonly consumed in Western countries were much less effective.

Introducing human prostate cancer cell lines into mice, Wu and his colleagues saw a particular enzyme called MAOA activate a cascade of signals that made it easier for tumor cells to invade and grow in bone.

In studies on rats and mice, 3BP was reported to reduce growth of tumors or even shrink them, and experiments on human cancer cell lines showed that combining another chemotherapeutic with 3BP increased its efficacy.

Until recently, Ain was renowned for a highly prized repository of 18 immortal cancer cell lines, which he developed by harvesting tissue from his patients» tumors after removal, carefully culturing them to everlasting life in vials.

Overexpression of ZMYND11 in an osteosarcoma cell line and a triple - negative breast cancer cell line inhibited tumor growth.

In this new study, described Feb. 21 in Cell Reports, Semenza and his colleagues conducted gene expression analysis of multiple human breast cancer cell lines grown in the laboratory after exposure to chemotherapy drugs, like carboplatin, which stops tumor growth by damaging cancer cell DNA.

This technique is able to distinguish cancer cell lines with differing metabolic activities and reveals heterogeneous uptake patterns in neurons, mouse brain tissues and tumor tissues with clear cell - to - cell variations.

The effects of the pactamycin analogs, called TM - 025 and TM - 026, were characterized in head and neck cancer cell lines, which cause the eighth most common cancer in the world.

To address these questions, Dang, Altman, and Hsieh collaborated with Penn colleague, Aalim Weljie, PhD, research assistant professor of Pharmacology, using an osteosarcoma cancer cell line to study the interaction of MYC and metabolism in cancer cells.

But they also warn that their work shows the danger of drawing general conclusions about cancer - relevant phenotypes from a single cancer cell line.

When European researchers published the genome of the HeLa cancer cell line last month, they didn't think to ask for permission from the family of Henrietta Lacks, the woman those cells came from — what some experts say was a serious ethical lapse.