Sentences with phrase «cancer stem»

Ever since, there has been no more doubt about the general existence of cancer stem cells.

It has been shown to target breast cancer stem cells, while leaving alone the good stem cells.

New research finds that a protein that fuels an inflammatory pathway does not turn off in breast cancer, resulting in an increase in cancer stem cells.

The antibody also shows promise in targeting cancer stems cells and in preventing the growth and spread of ovarian, lung, breast, colon, pancreatic and other cancers.

The results show that they both have an effect on cancer stem cells.

The science behind these new therapy and treatment approaches concentrates on self - renewing cancer cells — what are commonly referred to as cancer stem cells.

Some researchers believe eliminating cancer stem cells may be key to controlling cancer.

The trial involves combining standard chemotherapy with a drug that has been found in laboratory studies to attack cancer stem cells.

This includes identifying pancreatic cancer stem cells, the small number of cells within a tumor that fuel its growth and spread.

They used a newly established cell model that enables scientists to isolate cancer stem cells directly from patient tumor.

They were able to block proliferation of several cancer stem cell lines.

Another view is that tumors can become resistant to therapy by a process called cell fate decision, by which some tumor cells are killed by therapy and others become cancer stem cells.

These cells, named cancer stem - like cells, share many characteristics with the body's normal stem cells.

When the switch does not get turned off, it enables cancer stem cells to grow.

Can any cancer cell form another tumor, or is it only select cancer stem cells that give rise to new cancer cells?

Although cancer stem cells have been identified in many different types of cancer, it is becoming increasingly clear that the properties of these cells may vary greatly among the different tumor types.

Scientists have shown that an inflammatory process within the breast itself promotes growth of breast cancer stem cells.

Their stem cell - like properties enable them to maintain a pool of cancer stem cells within the tumor, as well as to produce new mature tumor cells.

This is the only cell therapy in clinical trial phase, which precisely target cancer stem cells.

Researchers measure the impact on cancer stem cell metabolism of 3 natural substances, 3 experimental pharmaceuticals and 1 clinical drug.

It seems in cancer stem cells these genes become up regulated, producing excessive amounts of these transcription factors.

Breast cancer stem cells exist in two different states and each state plays a role in how cancer spreads, according to an international collaboration of researchers.

Studies have shown that these cancer - fighting compounds and enzymes found in broccoli and other cruciferous vegetables may actually prevent the relapse of certain cancers by killing cancer stem cells.

if a picture were to tell a thousand words, the lady is sick from obesity, diabetes, high blood pressure, kidney and liver problems, circulatory problems, heart problems, and probably some sort of cancer stemming from the 50 - 60 lbs of visceral fat.

1) Notch - 1 induces epithelial — mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells:

«Grape - based compounds kill colon cancer stem cells in mice.»

However, little is known about the specific stem cell - related effects by which ONC201 inhibits cancer stem cells from renewing.

The discovery, published online today in Cell, illuminates a major shift in understanding anti-tumour mechanisms and identifies a promising druggable target against colorectal cancer stem cells, says principal investigator and lead author Dr. Daniel De Carvalho, a scientist at Princess Margaret Cancer Centre, University Health Network.

«Zika virus kills brain cancer stem cells: Virus potentially could be used to treat deadly disease.»

In 2011, they applied big data mathematical and bioinformatics models to screen for existing FDA - approved medications that might be effective against cancer stem cells.

Whitehead Institute researchers have determined that in basal breast cancer cells a transcription factor known as ZEB1 is held in a poised state, ready to increase the cells» aggressiveness and enable them to transform into cancer stem cells capable of seeding new tumors throughout the body.

«Some cells that we call cancer stem cells adopt deadly characteristics where they can travel through the bloodstream to other tissue and form new tumors.

«What is important is to be able not only t0 target leukemia cells selectively, but also to eradicate cancer stem cells as well,» Fasan says.

Together, these signals activate ADAR1, which edits specific RNA in a way that stabilizes a gene that can make cancer stem cells more aggressive.

«Novel mechanism controlling lung cancer stem cell growth discovered.»

But it has been harder to test whether cancer stem cells fuel the growth of tumors in other tissues.

Motivated in part by a family history of cancer, Chefetz began studying cancer stem cells in 2009 as a postdoc at Yale University with Gil Mor, a reproductive sciences professor who focuses on ovarian cancer.

«We would like to accelerate necroptosis to kill as many cancer stem cells [as possible],» she says.

In normal cells, this is a part of the wound repair process when PGE2 induces tissues stem cells to regrow; in cancer PGE2 ironically induces regrowth of more cancer stem cells in between chemotherapy cycles, Kurtova and Xiao said.

«Genetic tracking identifies cancer stem cells in human patients.»

This Registered report describes the proposed replication plan of key experiments from «Interactions between cancer stem cells and their niche govern metastatic colonization» by Malanchi and colleagues, published in Nature in 2012 (Malanchi et al., 2012).

«These new findings demonstrate that by inhibiting Pin1, you can degrade this fusion oncogene, thereby stopping cancer stem cells from replicating.

DiFeo is planning to test indomethacin's ability to specifically target ovarian cancer stem cells in patient tumors in a phase 1 clinical trial.

The multidisciplinary team is comprised of researchers based in Cardiff University's European Cancer Stem Cell Research Institute (ECSCRI) and the School of Pharmacy and Pharmaceutical Sciences.

Elusive Cancer Stem Cell Identified Johns Hopkins Kimmel Cancer Center scientists have identified the cell likely to be responsible for the development of multiple myeloma, a cancer of the bone marrow that destroys bone tissue.

Newer lines of research are focused on understanding cancer stem (CSC) cell biology so that therapies targeting them can be developed.

«How cancer stem cells thrive when oxygen is scarce.»