Sentences with phrase «drug combinations»

Her research efforts are dedicated to developing new drug combinations for patients with advanced cancer.

In addition, they plan to replicate the results of this study and test new drug combinations against the disease in various animal models in which other genes are changed.

Different drug combinations work in different ways to fight cancer cells.

The aim of the grant program is to support projects that address critical unanswered research questions that will help move the field towards new device / drug combination therapies.

From testing new treatments, to improving drug combinations, our researchers are running clinical trials to ensure more people survive cancer.

Previous efforts to screen potential drug combinations only analyzed use of a few drugs against a limited number of cell lines or lines in which genomic variations were poorly understood.

Patients were treated for 12 weeks with the 3 - drug combination regimen, with 24 weeks of follow - up after completion of treatment.

The computer then predicts three drugs and three drug combinations likely to target those master regulators.

The most successful drug combination tested almost doubled lifespan, a feat never reported before.

Effectively research what new drugs are emerging and new drug combination issues that could affect public health, document current drug user numbers, and provide numbers for needed resources.

And certain new drug combinations can lower LDL levels by 75 percent.

We have developed software for conducting 3 - D response surface and response envelope analyses of drug combinations for the statistical determination of synergy, additivity, or antagonism.

Kenar D. Jhaveri, MD, and Richard Barnett, MD, Feinstein Institute for Medical Research scientists and Northwell Health Department of Internal Medicine nephrologists, published a Letter to the Editor in the New England Journal of Medicine, which profiles a novel drug combination with the potential to help prevent rejection of a donor kidney in transplant patients undergoing cancer treatment.

One therapeutic tool they are advancing involves gathering pancreatic cancer cells from the bloodstream, assembling them into replicas of a patient's tumor and testing various drug combinations on the copies to develop personalized medicine for each patient.

Another example, he said, is the National Cancer Institute's drug formulary launched in 2017 that helps researchers quickly access commercial cancer drugs under development, to test promising drug combinations in clinical trials, an effort made possible after difficult issues of intellectual property, access and licensing were worked out.

«Scientists track metabolic pathways to find drug combination for pancreatic cancer.»

«Monthly preventative treatment with a new drug combination reduces malaria in children.»

Only when we functionalize the entire network can we begin to treat individual patients with rational drug combinations based on their unique tumor genome — the promise of personalized medicine.

In what scientists call a «sinister development,» a malaria parasite resistant to a widely used drug combination is on the march in Southeast Asia.

«Our test should make it possible to find drug combinations that kill ALL the cancerous cells in a tumor,» Skala said.

Cystic fibrosis patient Els van der Heijden received a new drug combination based on organoid tests.

The novel drug combination allows the rapidly emerging cancer therapies called immune checkpoint inhibitors to be incorporated into a transplant patient's cancer treatment regimen.

Hopefully, this knowledge, coupled to utility of the mAGES system, will spark the search for small molecule drug combinations which can safely and efficiently modulate the involved pathways and promote astrocyte to NSC conversion.

The combination — pairing a drug targeted against mutations in the BRAF gene with a second drug that targets another important signaling pathway — was discovered through one of the largest screens of cancer drug combinations conducted to date.

The work was carried out in mice, so we'll have to wait for the results from clinical trials to find out if the treatment is safe and effective in people, but it's certainly a promising approach and could lead to more potent drug combinations that benefit patients.»

So effective, in fact, that the best drug combinations suppress HIV to undetectable levels in most patients.

The German Institute for Quality and Efficiency in Health Care (IQWiG) now examined in a dossier assessment whether the new drug combination offers an added benefit over the appropriate comparator therapy.

And City of Hope is a leader in personalized medicine, including clinical trials here that are finding new and more effective drug combinations to kill lung cancer cells.

Trimethoprim - sulfamethoxazole is a highly synergistic antimicrobial drug combination that is widely used to treat a variety of bacterial and fungal infections.

«We hit the tumor with a punch and see how it responds,» said Skala, «It is cheap and fast and adaptable to high - throughput screening so it can be used to test dozens of drugs or drug combinations at the same time.»

«It tells us the way we can look for other drug combinations that will have similar synergistic activity,» said Baughn.

Immense possibilities for testing patient - derived multicellular tumor spheroids / organoids for disease / biomarker - oriented drug activity and profiling using single - and pair-wise standard / targeted drug combinations

It did, with the two - drug combination killing off pancreatic cancer cells more effectively than everolimus alone.

Next, the researchers injected cells from five patients» colorectal tumors into different zebrafish embryos and dosed the fish with the same chemotherapy drug combination the patients had received.

«New study is an advance toward preventing a «post-antibiotic era»: Biologists identify drug combinations that may be highly effective at reducing growth of deadly bacteria.»

«Simple two - drug combination proves effective in reducing risk of stroke.»

The German Institute for Quality and Efficiency in Health Care (IQWiG) has assessed documents subsequently submitted by the drug manufacturer in the commenting procedure on the dossier assessment of the fixed - dose drug combination of ledipasvir and sofosbuvir (trade name: Harvoni).

A 2009 study found that 65 % of physician members of the ASBP who responded to a survey prescribe drug combinations that are not FDA - approved for the treatment of obesity.

The fixed - dose drug combination ombitasvir / paritaprevir / ritonavir (trade name Viekirax) has been available since January 2015 for the treatment of adults with chronic hepatitis C infection.

«Two - drug combination shows promise against one type of pancreatic cancer.»

A second paper from the same study, which is forthcoming in The Lancet, shows that the same drug combination is superior to aspirin for the risk of losing limbs or severe limb ischemia (limitation of blood flow to a limb), as well as decreasing cardiovascular events, among patients with peripheral artery disease (PAD).

This enables the researchers to test different drug combinations efficiently and without burdening the patient.

Take any Hepatitis C drug combination containing ombitasvir / paritaprevir / ritonavir, with or without dasabuvir.

STATEN ISLAND, N.Y. — Sen. Charles Schumer held a pack of gum in one hand and a container of synthetic pot in the other as he called on the federal Drug Enforcement Agency to crack down on the sale of legal chemical substances used to create new synthetic drug combinations.

Fewer veterans received prescriptions for risky dosages of opioid painkillers after a national initiative took aim at reducing high doses and potentially dangerous drug combinations, a new study finds.

«Clinical trial using immunotherapy drug combinations to treat lung cancer appears safe.»

One form of pancreatic cancer has a new enemy: a two - drug combination discovered by UF Health researchers that inhibits tumors and kills cancer cells in mouse models.

Using tumor biopsies from BRAF melanoma patients treated with either BRAF inhibitors or with combined BRAF and MEK inhibitors, a recently FDA - approved drug combination to fight the other mechanisms of resistance, the researchers found that tumors resistant to the BRAF inhibitors had increased levels of autophagy compared with baseline tumors.

«We will develope a series of computational methods for drug combination prediction, modeling and data analysis.