An
"endotoxin" is a harmful substance that is found within certain types of bacteria. When these bacteria are destroyed or disintegrated, the
endotoxin is released and can cause sickness or infection in the body.
Full definition
Western lifestyle is associated with a sustained low grade increase in inflammation - increased levels
of endotoxin in the body and increased activation of Toll - like receptors and neutrophils, which leads to impaired immunity and reduced resistance to disease, changes which might explain the epidemic of chronic diseases spreading around the globe.
Fructose consumption strongly promotes bacterial growth in the intestine and increases levels of bacterial
endotoxins in the body.
The effectiveness of in vivo root planing in removing
bacterial endotoxin from the root of periodontally involved teeth.
Without home care, tartar forms on teeth but migrates below the gums, resulting in the release of
endotoxins from the bacteria that destroy the bone around the tooth root.
The paper Peter cited actually found an increase in blood
endotoxin levels after people were fed a high - fat meal:
The use of NSAIDS is associated with an increase in
endotoxins as well as gram - negative bacterial concentrations.
Her earlier work suggested that a tolerance
for endotoxin is what protects children raised on farms, and this new study provides strong support for this protein's role in guarding against allergies.
Any health condition that can cause water retention, such as heart or liver failure, bacterial
endotoxin release or prostaglandins that impairs kidney function will also cause reading to be low.
Subsequent work has identified that processed meats also release dead bacterial products
called endotoxins into the bloodstream that stun arteries.
In another study, a high - fat meal was worse than smoking three cigarettes in prompting the release of high levels of
endotoxins into the blood of healthy volunteers.
«The virtually complete loss of contact with organisms such as intestinal worms that don't
produce endotoxin is known to be an important contributor to the over-inflammatory state of Western immune systems,» he says.
Check out my three videos exploring the mystery The Leaky Gut Theory of Why Animal Products Cause Inflammation, The
Exogenous Endotoxin Theory, and Dead Meat Bacteria Endotoxemia.
So it stands to reason that a higher - fat diet would carry
more endotoxin into the body.
CONCLUSIONS These studies have highlighted that exposure to a high - fat meal elevates
circulating endotoxin irrespective of metabolic state, as early as 1 h after a meal.
Check out my videos exploring the mystery: The Leaky Gut Theory of Why Animal Products Cause Inflammation; The Exogenous
Endotoxin Theory; and Dead Meat Bacteria Endotoxemia.
For example, bacteria inherently grows on meat and
endotoxins found in meat is an inherent trait.
It has been shown to improve mucosal barrier function and
reduce endotoxin influx from the intestinal tract.
The ANDS also asks about studies comparing the bioavailability of the brand name drug with that of the proposed generic drug, and about the results of bacterial
endotoxin tests for sterile drugs.
In the Collagen Antibody Induced Arthritis (CAIA) model, arthritis is stimulated through the administration of a cocktail of monoclonal antibodies that are directed to conserved auto - antigenic epitopes of collagen type II, followed by
endotoxin challenge.
Interestingly, the low - grade inflammation correlates with circulating levels of a plasma
endotoxin known as lipopolysaccharide (LPS).
Back in the Netherlands, scientists gave both the twelve trained subjetcs and twelve healthy non-trained volunteers an injection
containing endotoxin, a component from the cell - wall of bacteria that elicits a response from the immune system.
This study also showed that the probiotic reduced intestinal permeability and
blood endotoxin levels.
The hygiene hypothesis postulates that early exposure to
endotoxin decreases the risk of developing allergic disease by a mechanism that has not been fully elucidated, but may be related to TLR stimulation as previously mentioned.
«Accordingly, we examined the effects of allergic disease on respiratory health in two sets of patients with COPD, one a nationally representative sample of 1,381 COPD patients from the National Health and Nutrition Survey III (NHANES III) and the other a cohort of 77 former smokers with COPD from a study of the effects of
endotoxin exposure on health status.»
Children with gene mutations that disrupt the functioning of an enzyme called A20 are more likely to have asthma and allergies, so Bart Lambrecht of Ghent University in Belgium and his team wondered whether A20 may be involved in
helping endotoxins train our immune systems.
One explanation is that children today encounter
less endotoxin, a bacterial protein found on the surface of many common species, including E. coli, that may be important for damping down overactive immune systems.
Animal experiments Effect of yeast supplementation on digestibility, fecal microbiota and
serum endotoxin levels in non-exercising and exercising horses — A.A.O. Gobesso — Livestock Science
Bacterial
endotoxin activity in human serum is associated with dyslipidemia, insulin resistance, obesity, and chronic inflammation.
But it turns out the body has mechanisms to regulate how much
endotoxin enters the body.
Similarly, Bruce Beutler, an immunologist at the University of Texas Southwestern Medical Center in Dallas who won the 2011 Nobel Prize in physiology or medicine for discovering
how endotoxins activate the immune system, says helping his father work in his genetics lab gave him an early advantage.
They found that normal mice had no allergic responses to the mites, although some normal mice from a control group not exposed to
endotoxin did.
Protective Effects of Medium - Chain Triglycerides on the Liver and Gut in Rats
Administered Endotoxin: In addition to dietary medium chain triglycerides preventing alcohol - induced liver injury, they may also prevent liver injury, gut permeability, and gut injury when in a state of endotoxemia.
Mutations of the gene Lps selectively impede lipopolysaccharide (LPS) signal transduction in C3H / HeJ and C57BL / 10ScCr mice, rendering them resistant to
endotoxin yet highly susceptible to Gram - negative infection.
But William Parker at Duke University Medical Center in Durham, North Carolina, doesn't
think endotoxin can explain why modern city - dwellers have such overactive immune systems.
Essential role of IRF - 3 in lipopolysaccharide - induced interferon - β gene expression and
endotoxin shock.