Sentences with phrase «epigenetic alterations»
"Epigenetic alterations" refer to changes in gene activity that are not caused by changes in the DNA sequence itself. These alterations can be caused by various factors such as environmental influences and lifestyle choices, and they can affect how genes are expressed or regulated. In simpler terms, it means that certain external factors can affect how our genes function without changing the genes themselves. Full definition
One line of research traces memory loss in old age to epigenetic alterations in brain neurons.
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The authors conclude that the potential interactions of diet, gastrointestinal microbiome, and inflammation can all contribute to epigenetic alterations in psychiatric disorders.
Approximately 50 % of epithelial ovarian cancers (EOC) exhibit defective DNA repair via homologous recombination (HR) due to genetic and epigenetic alterations of HR pathway genes.
In addition, the Izpisua Belmonte team is developing epigenetic editing technologies to reverse epigenetic alterations with a role in human aging and disease.
DNA methylation and other epigenetic alterations — chemical changes to DNA that can alter a gene's expression without affecting its protein - coding sequence — may underlie some of the lasting biochemical havoc, Ghanei says.
The study, led by Dr. Yasmin Hurd of the Icahn School of Medicine at Mount Sinai, New York, provides the first direct evidence of opiate - related epigenetic alterations in the human brain.
Through epigenetic alterations, our genomes retain something like a memory of the environmental signals received during the lifetimes of our parents, grandparents, great - grandparents, and perhaps even more distant ancestors.
Yet people who make decisions about safe levels of exposure to chemicals, heavy metals and other environmental factors generally aren't including epigenetic alterations in their deliberations.
The team has been able to prove that such epigenetic alterations are associated with the increased levels of an enzyme, namely DNA methyltransferase 3A (DNMT3A), which is responsible for the acquisition of the suppressive properties of these cells that develop in the tumoral microenvironment.
«We've analyzed epigenetic alterations, namely the chemical signal called DNA methylation in 500 breast tumors and have compared the patterns obtained with the clinical behavior of these cancers,» says Esteller.
In this study, published in the journal Cell Reports, and led by Dr. Esteban Ballestar (IDIBELL), the comparison of the epigenetic profiles between dendritic cells and myeloid - derived suppressor cells has allowed them to identify the existence of specific epigenetic alterations that associated with the development of myeloid - derived suppressor cells as a result of exposure to prostaglandin E2.
Transgenerational glucose intolerance with Igf2 / H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia
Epigenetic Therapy A novel two - drug treatment targets epigenetic alterations that help give cancer cells their edge.
The lab is currently focused on utilizing these models to interrogate how genetic and epigenetic alterations influence lineage dependencies, genomic instability, DNA repair, replicative stress, and metabolism.
Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders
«Epigenetic alteration of a vitamin B12 gene shines new light on our understanding of rare diseases.»
Especially in this vulnerable phase, the kidney is prone to a number of mechanistic changes driven by epigenetic alterations.
The lab investigates consequences of epigenetic alterations in neuronal cancers and neurodegenerative diseases using a combination of biochemistry, cell and molecular biology with genome wide approaches to gain mechanistic insight into how chromatin architecture is modified in disease.
«Epigenetic alteration a promising new drug target for heroin use disorder.»
Study results suggest that pharmacological action on these epigenetic alterations may be helpful in slowing disease progression.
Widschwendter, who led the study, said: «Our work provides clear evidence that it is not only genetic alterations which trigger and lead to cancer but that epigenetic alteration can also be the initiating step.»
The authors hypothesize that in addition to these functions, epigenetic alterations may also serve as a common trigger through which susceptible and genetically predisposed stem cells become cancer progenitor cells.
This epigenetic alteration of gene activity in brain cells that receive this neurotransmitter showed for the first time that dopamine deficiencies can affect a variety of behavioral and physiological functions regulated in the prefrontal cortex.
«Though breast and ovarian cancer are distinctly clinically different, our analysis uncovered many overlaps, particularly with respect to genetic and epigenetic alterations,» explained corresponding author Sibaji Sarkar, PhD, instructor of medicine at Boston University School of Medicine (BUSM).
Epigenetic alterations are thought to be key molecular switches that are involved in the development of cancer.
In the mustard plant Arabidopsis, for example, epigenetic alterations in leaf and flower shape can be passed on to offspring.
While evidence obtained in our and other laboratories strongly suggests that H. pylori triggers a transcriptional response, epigenetic alterations and DNA damage in infected cells, most of the data supporting these findings rest on fragmentary analyses of clinical samples and cells infected in vitro.
It is known that both hypoxia and consecutive hypoxia / reoxygenation can exert a variety of effects on tumor cell biology, including activation of pro-survival signal transduction pathways, aberrant genetic and epigenetic alterations, and increased tumor angiogenesis.
A clear and growing body of evidence supports the notion that epigenetic alterations, such as DNA methylation, occur early in and contribute to tumor formation.
A new topic of significant interest is the area of epigenetic alterations that can occur during embryo culture in vitro, and the subsequent impact on phenotype.
This paper, Microbiome, inflammation, epigenetic alterations, and mental diseases, sums it up perfectly, reporting that recent findings show that the onset and development of mental diseases such as autism, bipolar disorder, schizophrenia, and depression can not be well described by the one - gene / one - disease approach: