Sentences with phrase «gene inactivation»
"Gene inactivation" refers to the process of turning off or disabling a particular gene in an organism's DNA. It means that the gene is no longer able to produce certain proteins or perform its normal functions. Full definition
Yesterday, PTO granted a patent that claims gene inactivation by the use of chimeric restriction endonucleases to the Pasteur Institute and Boston Children's Hospital.
sciencemag.org
His research currently focuses on determining the mechanisms and consequences of cohesin gene inactivation in human cancer.
Lastly, the oldest age of the leprosy bacteria's pseudogenes suggest that gene inactivation began approximately 20 million years ago.
A quirk of the physiology of C. elegans means that such gene inactivation can occur simply if the RNAi molecule is eaten by the worm.
It has also been suggested that methylation is not the initial event in triggering gene silencing in cancer; rather, the methylation of the promoter CpG islands is a consequence of prior gene inactivation, and it is a mechanism for locking the chromatin in a repressed state (5, 13, 37).
Rational design of highly active sgRNAs for CRISPR - Cas9 - mediated gene inactivation.
The Conklin lab has also developed CRISPR - inhibition cell lines for high throughput gene inactivation screens.
Gene inactivation by mutation is therefore inefficient because when one copy is inactivated, the second copy usually remains active and takes over.
The process of gene inactivation is thought to be a phenomenon of all mammals, including humans.
«The gene inactivation of some of these enzymes results in improved drug efficacy against Mtb,» he said.
Researchers from the Institute of Psychiatry and colleagues found evidence that gene inactivation is often skewed toward one X chromosome over the other, and that this bias may already be established in early childhood.