The phrase
"human microbiome" refers to the collection of microscopic organisms (like bacteria, viruses, and fungi) that live inside and on our bodies. These organisms are essential for our overall health and play an important role in various bodily functions.
Full definition
Previous human microbiome studies comparing the two techniques have also shown that shotgun produces equivalent, if not better, results.
In the last four years, the U.S. - based
Human Microbiome Project used genomic analysis to identify bacteria, viruses, fungi, archaea, and protozoa in the noses, gums, tonsils, genital tracts, and guts of 242 healthy Americans between the ages of 18 and 40; more than 11,000 samples were taken in all.
The study, the first to rigorously show that identifying people from microbiome data is feasible, suggests that we have surprisingly unique microbial inhabitants, but could raise potential privacy concerns for subjects enrolled
in human microbiome research projects.
The new study is one of more than a dozen papers authored or co-authored by CU - Boulder researchers published in the past several years
on human microbiomes.
Her first studies on bacterial diversity in the human digestive tract, which were published in «Science» in 2005 and 2006 are milestones in the field of
human microbiome research,» states Michael Schloter.
Just
as human microbiome research is rapidly changing our perspectives on human health and behavior, the interactions between trees and their soil microbiomes may dramatically change how we think about the health and behavior of forests.
«We found that when you perturb gut microbes early in life among mice and then stop the antibiotics, the microbes normalize but the effects on host metabolism are permanent,» says senior author Martin Blaser, MD, the Muriel G. and George W. Singer Professor of Translational Medicine, director of the NYU
Human Microbiome Program, and professor of microbiology at NYU School of Medicine.
In today's digest, check among many interesting articles: the evolution within
human microbiome by T.D. Lieberman, unique microbial biodiversity residing in hadal trenches by L.M. Peoples, changes in community composition in coastal water following exposure to oil and oil dispersant by S.H. Doyle.
Pre-print: A comprehensive automated pipeline
for human microbiome sampling, 16S rRNA gene sequencing and bioinformatics processing — Luisa W Hugerth — bioRxiv
Our skin has good bacteria that is «live» and already there,
called human microbiome and we experience constant challenges in our gut and on our skin with the good vs the bad bacteria.
The program will bring together scientists from different organizations to
study human microbiomes and how they can address several diseases.
Optogenetic regulation of transcription to promote biosynthesis of desired chemicals from fungi, the effect of yeast and bacteria on floral nectar, guidelines and best practices for
human microbiome sampling / sequencing / processing.
The research is part of a bigger endeavour called the
International Human Microbiome Consortium, which aims to identify and study all the microbes living in and on our bodies.
She started Mostly Microbes as a reputable, scientific voice in the discussion
about human microbiome research to help distinguish research findings from hype.
Warinner is pioneering the study of
ancient human microbiomes, and in 2014 she published the first detailed metagenomics and metaproteomic characterization of the ancient oral microbiome in the journal Nature Genetics.
Of note today: An evaluation of
multi-site human microbiome temporal stability over six months; The impacts of 1,000 non-antibiotic drugs on the in vitro gut microbiome; Caspase - 1 might modulate the relationship between stress, the gut microbiome, inflammation and depressive - like behaviour in mice; And the impact of warming on the Antarctic soil microbiome
The U.S. -
based Human Microbiome Project used genomic analysis to I.D. microbes in the noses, gums, tonsils, genital tracts and guts of more than 200 Americans.
These new residents shielded mice against Citrobacter infection, Finlay reported 9 March here at the International
Human Microbiome Congress.
Meanwhile, the origins of many diseases may become clearer thanks to the first comprehensive census of the
entire human microbiome, reported in two papers in Nature and 12 papers in the open - access PLoS journals, as well as a collection of papers in last week's Science.
Across several different zoos on three different continents, all captive primate microbiomes showed the same pattern of converging toward the
modern human microbiome.
These include the
US Human Microbiome Project, the Canadian Microbiome Initiative, MetaHIT (involving the European Union and China) and the Human Metagenome Consortium in Japan.
An April study in Science Advances drove this point home: A separate team found the highest
human microbiome diversity ever seen in an isolated Yanomami tribe, discovered by Westerners only in 2009 in southern Venezuela.
The coprolites» exquisite preservation allowed the scientists to make the first confirmation of an ancestral,
distinctly human microbiome, dating back to about A.D. 700.
This opens the door to
connecting human microbiome samples between databases, which has the potential to expose sensitive subject information — for example, a sexually - transmitted infection, detectable from the microbiome sample itself,» said lead author Eric Franzosa, research fellow in the Department of Biostatistics at Harvard Chan.
In 2008, when he fed Lactobacillus to mice with a
transplanted human microbiome, he observed metabolic changes in the animals» gut, liver, kidneys, and parts of the brain.
Mice raised with
human microbiomes never develop mature immune systems, which may explain the rise in immunological illnesses
«Applying DNA sequencing to a study of the skin's fungi is the natural progression in understanding microbial life that co-exists on our bodies,» said NHGRI Scientific Director Daniel Kastner, M.D., Ph.D. «Along with recent genome sequencing to define bacterial diversity, this analysis of fungal diversity provides a more
complete human microbiome picture.»
While strides have been made in our effort to understand the importance of the
complex human microbiome, the exact functions of the majority of our gut associates remain unknown, as is their impact on our metabolism and overall physiology.
It is plausible that direct emission of bacterial cells from an individual results in a
detectable human microbiome signal that is traceable to a particular individual, similar to what has been reported after contact with indoor surfaces (Fierer et al., 2010), although this has never been demonstrated.
Gut microbiota diversity according to dietary habits and geographical provenance — Bruno Senghor — Human Microbiome Journal
Multi-site
human microbiome Differential contributions of specimen types, culturing, and 16S — Lone Heimann Larsen — Journal Of Clinical Microbiology
We are excited to add this new study to our repertoire of
ongoing human microbiome studies as it will enhance our knowledge in this important area of research.»
«There's so much going on in the
whole human microbiome right now, there's so much research, that I personally think this is just the tip of the iceberg,» he says.
The NIH Common
Fund Human Microbiome Project (HMP) was established with the mission of generating research resources enabling comprehensive characterization of the human microbiota and analysis of their role in human health and disease.
The authors of a critical study published in 2013 contend there is a strong correlation between the prevalence of glyphosate and a
disrupted human microbiome.
«Now that we understand what the
normal human microbiome looks like, we should be able to understand how changes in the microbiome are associated with, or even cause, illnesses.»
«The distal gut of a human is one of the densest microbial ecosystems on the planet,» says Stanford University microbiologist David Relman, a pioneer
in human microbiome research.
Phrases with «human microbiome»