Sentences with phrase «human somatic cells»

iPSCs created through the reprogramming of human somatic cells retain genomic marks of the donor's age.

In late 2007, the development of IPS cells from human somatic cells prompted great excitement in the field providing the potential for researchers to obtain pluripotent stem cells without the controversial use of embryos and also to produce them on a much larger scale than would be feasible using embryos.

The strict limit in proliferative potential of normal human somatic cells - a process known as replicative senescence - is highly relevant to the immune system, because clonal expansion is fundamental to adaptive immunity.

Induced pluripotent stem (iPS) cells have been generated from mouse and human somatic cells by introducing Oct3 / 4 and Sox2 with either Klf4 and c - Myc or Nanog and Lin28 using retroviruses or lentiviruses.

More recently, researchers have induced stem cells from diseased human somatic cells, which may serve as new model systems for various illnesses.

The telomerase deficiency of human somatic cells reduces the risk of cancer development, as telomerase fuels uncontrolled cancer cell growth.

Kohli, Manu, et al. «Facile methods for generating human somatic cell gene knockouts using recombinant adeno ‐ associated viruses.»

WIKIMEDIA, CSIROAfter human somatic cells are reprogrammed into induced pluripotent stem cells (iPSCs), the resulting cells retain both genetic and epigenetic indicators of the age of the person who donated the somatic - cell progenitors, scientists have found.

The reprogramming of human somatic cells into induced pluripotent stem cells (iPSCs) offers tremendous potential for cell therapy, basic research, disease modeling, and drug development.

Rago C, Vogelstein B, Bunz F. Genetic knockouts and knockins in human somatic cells.

However, this is inefficient and has a low throughput method so I aim to use our growing knowledge of epigenetics to devise strategies for «reprogramming» human somatic cells towards a stem cell like phenotype.

Since the discovery that telomerase is repressed in most normal human somatic cells but strongly expressed in most human tumors, telomerase has become a target for therapeutic agents to combat human cancer.

Yu, J., Vodyanik, M. A., Smuga - Otto, K., Antosiewicz - Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., Slukvin, I. I., and Thomson, J. A. Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells.

In the following year, the direct reprogramming of human somatic cells was accomplished [2], [3].

Human somatic cells have 46 chromosomes, whereas sperm and eggs have 23.

Reprogramming human somatic cells to pluripotency represents a valuable resource for the development of in vitro based models for human disease and holds tremendous potential for deriving patient - specific pluripotent stem cells.

For hiPSCs, or any stem cells used as a source of human somatic cells, to be therapeutically effective in transplantation it needs to be shown that their progeny will function normally in the intended site for significant periods of time, which will require extensive testing first in animals, and then in appropriately designed (ideally in randomized, double - masked, multi-site) clinical trials.

The goal of our laboratory is to generate pluripotent stem cells from human somatic cells.