Sentences with phrase «human tumors»

The common pathway found in mouse models was also found in human tumors, suggesting that resistance could indeed be blocked in patients with the same drug as in mice.

In studies of laboratory - grown human tumor cell lines, the drug disrupted tumor cell division and prevented growth of advanced cancer cells.

Indeed, increased uptake and utilization of glucose has been reported for many human tumors.

Dogs are also helping advance the fight against human cancer as they serve as a model for various human tumors.

As such, mice carrying human tumors can help identify drivers of tumor growth and serve as excellent test subjects for investigating new drugs.

The studies were then extended to human tumor specimens.

The oldest known human tumor is from less than 4000 years ago.

The authors studied a standard panel of 60 established human tumor cell lines representing nine different human cancers, as well as several specimens of human primary ovarian cancer.

This provided the first evidence that genes injected directly into human tumor cells can take hold, function and stimulate the immune system without toxicity.

«This model was trained on genetic data from human tumors in The Cancer Genome Atlas and was able to predict response to certain inhibitors that affect cancers with overactive Ras signaling in an encyclopedia of cancer cell lines,» Greene said.

We do not know what cell types, microenvironments, or biological molecules mediate this effect in humans, what cell types take up delivered agents, and how our animal models correlate with human tumors in these respects.

The Ogretmen laboratory screened previously reported microarray data sets of several human tumor tissues (metastatic head and neck squamous cell carcinoma, melanoma, and renal cell carcinoma) and showed that, in these samples, only the levels of CerS4 were significantly decreased.

The results of a study of more than 100 human tumor samples show that the tumors expressing a high level of CCR3 present more frequent local dissemination.

This week, Fior, who is at the Champalimaud Centre for the Unknown in Lisbon, and her colleagues reported growing implanted human tumor cells in zebrafish larvae.

Francisco J. Sánchez - Rivera plans to comb through human tumor data to systematically identify recurring — but understudied — p53 mutations, and figure out how they wreak havoc in the body.

Since the discovery that telomerase is repressed in most normal human somatic cells but strongly expressed in most human tumors, telomerase has become a target for therapeutic agents to combat human cancer.

Cautiously, Augustin adds: «Obviously, we don't know if the findings of this study can be translated directly to human tumor patients.

In an animal model for glioblastoma in which human tumor cells are grown in a mouse's flank, treatment with coibamide A significantly reduced tumor size.

After revealing how these bacteria degraded the drug, he began to wonder if other bacteria might have a similar mechanism for inactivating the drug, and whether such bacteria might be found inside human tumors.

Researchers have isolated exosomes from tumors and from blood of patients with breast cancer, and from blood of mice with human tumors grown after breast implantation in mice, called ortoxenogratfs.

Tamayo and team tested REVEALER using The Cancer Genome Atlas (TCGA), the National Institutes of Health's database of genomic information from more than 500 human tumors representing many cancer types.

The researchers next will turn to analyzing the presence of myoferlin in samples from numerous human tumor types available in an Ohio State tissue bank, which will allow them to compare protein levels in tumors to clinical outcomes for the patients who provided the samples.

In their Nature Medicine paper, Fu and colleagues point out that these initial studies relied on human tumors transplanted into mice.

The mice were developed in Roussel's laboratory and are a powerful tool for testing the effectiveness of drugs against human tumors.

Under Folkman's guidance, she generated and characterized in - vivo models of human tumor dormancy.

The resulting conjugate, which binds COX - 2 selectively and strongly, is then injected into mice that have been implanted with COX - 2 expressing human tumors.

(2009) Functional evidence that the self - renewal gene NANOG regulates human tumor development.

Just as human tumors are staged according to aggressiveness and degree of development (early, late, etc.), so are the tumors found in cats.

Kilian said his team's synthetic microenvironment lies somewhere in the middle of two extremes in the field of modeling biology: the hard plastic plate, and expensive mouse avatars that are created by injecting human tumor cells into mice.

So Fior and her colleagues first determined whether human tumors behave the same in zebrafish.

So far they have tested the method extensively in mice and with six samples of human tumors using four anticancer drugs commonly used to treat breast cancer and two experimental drugs.

The centers are also cataloging genetic changes in human tumors together with the National Cancer Institute.

«Combined with cancer - specific targeting antibodies, these engineered macrophages swarm into solid tumors and rapidly drive regression of human tumors without any measurable toxicity.»

And with non-melanoma skin cancers being the most frequent human tumors, there is clearly a tremendous need to understand the underlying molecular mechanisms, to allow the development of drugs to treat these types of cancer.

«Philosophically, we wanted to provide the bladder cancer field an atlas of cells that mirror human tumors so our collective experiments could be most relevant to patients.

«We don't propose this as a current diagnostic or prognostic tool,» Costello says, «but showing that these alterations have real effect in human tumors allows us to explore the mechanisms that tumors use to resist therapies like cisplatin.»

Pten is the most prominent human tumor suppressor after p53.

Using the gene - editing system known as CRISPR, MIT researchers have shown in mice that they can generate colon tumors that very closely resemble human tumors.

We hope these data will help to move Jantibody closer to human tumor therapy, fulfilling one of my wife's last wishes.»

Once the Food and Drug Administration approves the gene gun as a medical device, Sun and Yang hope to aim it at human tumors, particularly those beyond the reach of a scalpel.

I. Develop a 3D cancer atlas Create dynamic 3D maps of human tumor evolution to document the genetic lesions and cellular interactions of each tumor as it evolves from a precancerous lesion to advanced cancer.

Next, they genetically modify a fruit fly to dial up or down the activity of those genes, and, if possible, do so in the location where the original human tumor was found.

Ross Cagan's laboratory at Mount Sinai Hospital in New York City has developed a method to recreate human tumors in Drosophila, which is believed to have functional homologs for some 75 percent of human disease - causing genes.