Weekly alcohol consumption, brain atrophy, and white
matter hyperintensities in a community - based sample aged 60 to 64 years
(b) Sagittal proton density - weighted MR image of left foot confirms fracture line and periosteal reaction (arrow), and also shows diffuse
hyperintensity of entire metatarsal confirming acute nature of stress fracture.
Spatial distribution of white - matter
hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging.
The researchers estimated that a one percent increase in aortic arch pulse wave velocity (in meters per second) is related to a 0.3 percent increase in subsequent white matter
hyperintensity volume (in milliliters) when all other variables are constant.
Further research based on autopsy specimens and animal experiments will be needed to clarify the relationship and determine if the patients with
MRI hyperintensity in their brains have symptoms.
The findings are consistent with recent studies reporting
T1 hyperintensities in human patients receiving multiple injections of linear GBCAs for MRI scans.
The mechanisms by which Gd - CM administration
causes hyperintensity of the DN and GP remain unclear, Dr. Kanda said.
Dr. Kanda emphasized that there is currently no proof that gadolinium is responsible
for hyperintensity on brain MRI.
«Our results demonstrate that aortic arch pulse wave velocity is a highly significant independent predictor of subsequent white
matter hyperintensity volume and provides a distinct contribution — along with systolic blood pressure, hypertension treatment, congestive heart failure and age — in predicting risk for cerebrovascular disease,» Dr. King said.
The results showed that aortic arch pulse wave velocity helped predict white matter
hyperintensity volume, independent of the other demographic and cardiovascular risk factors.
Over time, «significant and persistent» MRI abnormalities (called T1 - weighted
signal hyperintensities) developed in the brains of rats receiving the linear GBCA, gadodiamide.
Since the patients in the study received only the linear type, additional research is needed to see if the macrocyclic type can prevent
MRI hyperintensity, according to Dr. Kanda.
«
Hyperintensity in the DN and GP on unenhanced MRI may be a consequence of the number of previous Gd - CM administrations,» said lead author Tomonori Kanda, M.D., Ph.D., from Teikyo University School of Medicine in Tokyo and the Hyogo Cancer Center in Akashi, Japan.
Patients showing gadolinium in the vitreous chamber at the later timepoint tended to be of older age, have a history of hypertension, and have more bright spots on their brain scans, called white matter
hyperintensities, that are associated with brain aging and decreased cognitive function.
Authors examined the association between SVD and AD pathology by looking at magnetic resonance imaging (MRI)- based microbleeds (MB), white matter
hyperintensities (WMH) and lacunes (which are measures for SVD) along with certain protein levels in cerebrospinal fluid (CSF) which reflect AD pathophysiology in patients with AD, VaD and healthy control patients.
However, in recent years, clinicians in Japan noticed that patients with a history of multiple administrations of Gd - CM showed areas of high intensity, or
hyperintensity, on MRI in two brain regions: the dentate nucleus (DN) and globus pallidus (GP).
Dr. Kanda noted that because patients with multiple sclerosis tend to undergo numerous contrast - enhanced brain MRI scans,
the hyperintensity of the DN seen in these patients may have more to do with the large cumulative gadolinium dose than the disease itself.
«
The hyperintensity of DN and GP on unenhanced T1WI may be due to gadolinium deposition in the brain independent of renal function, and the deposition may remain in the brain for a long time,» Dr. Kanda suggested.
The precise clinical ramifications of
hyperintensity are not known, but hyperintensity in the DN has been associated with multiple sclerosis, while hyperintensity of the GP is linked with hepatic dysfunction and several diseases.
The hyperintensity of both the DN and the GP correlated with the number of Gd - CM administrations.
White matter
hyperintensities, which appear as bright spots on brain MR images, are associated with accelerated motor and cognitive decline, Alzheimer's disease, stroke and death.
Seven years later, the volume of white matter
hyperintensities was determined using brain MRI.
The researchers also analyzed 15 other cardiovascular risk factors, as well as age, gender and ethnicity, as predictors of white matter
hyperintensities.
BFRT was inversely correlated with white matter
hyperintensities volume and BJLO with parietal cerebral microbleeds.
BACKGROUND AND PURPOSE White - matter
hyperintensities (WMHs) detected by magnetic resonance imaging are thought to represent the effects of cerebral small - vessel disease and neurodegenerative changes.
Abstract: Background: White matter
hyperintensities (WMH) were shown to predict cognitive decline following stroke or transient ischemic attack (TIA).
Background: White matter
hyperintensities (WMH) were shown to predict cognitive decline following stroke or transient ischemic attack (TIA).
Keywords: Cognition, stroke, small vessel disease burden, TABASCO, white matter hyperintensities
This is called white matter
hyperintensity (WMH) and can lead to mental decline.
Kato T, Murashita J, Kamiya A, Shioiri T, Kato N, Inubushi T. Decreased brain intracellular pH measured by 31P - MRS in bipolar disorder: a confirmation in drug - free patients and correlation with white matter
hyperintensity.
Gunde E, Blagdon R, Hajek T. White matter
hyperintensities: from medical comorbidities to bipolar disorders and back.
Features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter
hyperintensities, perivascular
Negativity can come in the form of cynicism, criticism, whining, attacking, pessimism, discontent, perfectionism, and
hyperintensity.