Blood samples and cervical tissue were collected from each patient at the beginning and end of the trial, letting scientists
compare immune cell responses before and after vaccination.
«It's difficult to
measure immune cell responses to therapeutic vaccines, but we believe that clinical studies could tell us more about the value and function of the vaccines if we check for the response in the lesions, where the immune system is fighting precancerous cells,» says Connie Trimble, M.D., associate professor of gynecology and obstetrics, oncology and pathology at Johns Hopkins» Kimmel Cancer Center.
Inflammation is a known feature of heart failure, and it is associated with high levels of inflammatory proteins called cytokines — including one called tumor necrosis factor alpha or TNF - a — that ramp
up immune cell responses.
«My whole work is
about immune cell responses to melanoma — how we can teach particular immune cells called killer T cells to recognise melanoma better, target melanoma better and kill melanoma better,» Katherine says.
5 — Immunity Activation: While conventional cancer treatments often suppress immune function, hyperthermia can actually enhance it — through a whole cascade
of immune cell responses.
This type of arthritis begins with an
abnormal immune cell response that causes too many white blood cells (the body's disease - fighters) to invade the joints.
Preliminary results of a small clinical trial show that a vaccine used to treat women with high - grade precancerous cervical lesions triggers
an immune cell response within the damaged tissue itself.