Sentences with phrase «in aged mice»

As a result, the hearing in aged mice or in mice exposed to intense noise was significantly better than their siblings without the gene.

The team examined tissues in mice for cellular stress following acute SD, and they also looked for cellular stress in aging mice.

By examining first pregnancies in aged mice, the team showed that, for mice as for humans, the risk of complications increases with age.

Animal studies show that whey protein increases longevity in aging mice and enhances liver and heart glutathione concentrations.

Citation: Ketogenic diet reduces mid-life mortality and improves memory in aging mice DOI: 10.1016 / j.cmet.2017.08.004

Co-enzyme q10 supplementation improves ovarian response and mitochondrial function in aged mice [abstract].

To determine whether rapamycin slows aging, we assessed a large number of structural and functional aging phenotypes in multiple cell types, tissues, and organs systems in our aging mouse cohorts.

These mice performed better than their normal counterparts on learning tests well into old age, and their brains did not exhibit the decline in neurogenesis typically seen in aged mice.

This image shows the discovery by researchers that induction of partial cellular reprogramming improved muscle regeneration in aged mice.

When the researchers genetically inhibited RbAp48 in the brains of healthy young mice, they found the same memory loss as in aged mice, as measured by novel object recognition and water maze memory tests.

This effect of RbAp48 inhibition on the DG was accompanied by defects in molecular mechanisms similar to those found in aged mice.

LA JOLLA, CA — A drug developed by scientists at the Salk Institute for Biological Studies, known as J147, reverses memory deficits and slows Alzheimer's disease in aged mice following short - term treatment.

Outflow of cerebrospinal fluid is lymphatic - specific and reduced in aged mice Steven Proulx, ETH Zurich

We therefore sought to determine whether rapamycin suppresses carcinogenesis in our aging mouse cohorts.

«And at the higher dose, we saw a rescue of the neural stem cell pool in aged mice.»

A genetic switch linked to memory impairment in ageing mice has been flipped back on, restoring failing brains to a more youthful state.

Additionally, the team found that induced lifelong overexpression of Nampt, an enzyme important in making NAD, prevented the natural decline in NAD and partially preserved exercise capacity in aged mice.

The GDF11 protein commonly found in the blood of young mice (the same protein that enhanced neurogenesis in aged mice) and placed in individual older mice was thought to have the same reversal effect on hypertrophy; however, more recent research suggests another molecule besides GDF11 may be at work.

The new study shows that treating mice with a drug that promotes Klotho expression reduces the levels of Wnt5A and decreases the growth of therapy - resistant melanoma in aged mice but, importantly, not in young mice.

However, when the researchers used drugs or mouse mutations that reduced the number of monocytes or removed TNF, they were able to restore antibacterial immunity in aged mice.

We show that factors found in young blood induce vascular remodeling, culminating in increased neurogenesis and improved olfactory discrimination in aging mice.

In aged mice with diabetes (represented on the right), Tregs are overexpressed in fat tissue and trigger insulin resistance.

The results indicate that pharmacological inhibition of 12 / 15 - lipoxygenase reverses learning and memory impairments and reduces Aβ and tau neuropathology, even after their onset in aged mice.

«High folic acid intake in aged mice causes a lowered immune response.»

Their study in aged mice indicates that high folic acid intake causes lowered immune function because natural killer (NK) cells, a particular type of immune cell, are less effective.

The study established a causal relationship between excess folic acid intake and lowered NK cell activity in an aged mouse model.

«The first question was whether RbAp48is downregulated in aged mice,» said lead author Elias Pavlopoulos, PhD, associate research scientist in neuroscience at CUMC.

Measurements of muscle fiber growth with and without boosting the function of β1 - integrin showed that the protein led to as much as 50 - percent more regeneration in cases of injury in aged mice.

The current study reports neurogenesis (neuron creation) occurred in the spinal cords of both adult and aged (over one - year old) mice of both sexes, although the response was much weaker in the aged mice, Dr. Zhang said.

We demonstrated that this device could reduce the KLRG1 - positive CD8 cell count in aged mouse blood by a factor of 7.3 relative to the total CD8 cell compartment, reaching a level typically seen only in very young animals.

SAN FRANCISCO, CA — A new study from the Gladstone Institutes has revealed a way to alleviate the learning and memory deficits caused by apoE4, the most important genetic risk factor for Alzheimer's disease, improving cognition to normal levels in aged mice.

New research, publishing in Nature, investigates how the nervous system and immune system communicate to control metabolism and inflammation in ageing mice.

Second, in the 16 - month cohort, rapamycin increased plasma glucose levels (which decreased in aged mice).

Few of the tested effects of rapamycin in our dataset were seen only in aged mice, not in young animals (RER, fat mass, γδ T cells, and CD44hi T cells); however, previous reports have shown aging - independent effects of mTOR inhibition on CD44 expression in T lymphocytes and fat mass (30, 31, 34).

Systemic factors can also affect these aging - associated events, either positively in which circulating monocytes enhance remyelination in aged mice (11, 12) or negatively in which the accumulation of chemokines in old blood can reduce neurogenesis and cognition in young mice (10).

, Dietary wolfberry supplementation enhances the protective effect of flu vaccine against influenza challenge in aged mice, 2014

In the same way, whereas NR supplementation increased muscle stem cell number in aged mice, thereby enhancing mitochondrial function and muscle strength, it reduced the expression of cell senescence and apoptosis markers [233]; the state of senescence is important to protect against carcinogenesis [234].

Consuming a Diet Supplemented With Resveratrol Reduced Infection - related Neuroinflammation and Deficits in Working Memory in Aged Mice Rejuvenation Res 2009 (Dec); 12 (6): 445 — 453 ~ FULL TEXT Aged mice treated peripherally with lipopolysaccharide (LPS) show an exaggerated neuroinflammatory response and cognitive deficits compared to adults.

Analysis of escape latencies (Figure 3B) during training indicated significant effects of aging and, possibly, rapamycin, such that escape latencies were increased in aged mice and were decreased by rapamycin treatment (P = 0.0021, P = 0.0548, and P = 0.2419 for age, treatment, and age / treatment interaction, respectively, 3 - way ANOVA with age and treatment as between - subjects factors and training day as within - subjects factor).

They used NK cell cytotoxicity, the ability of NK cells to destroy other cells, as an index of immune function in aged mice and focused on the implications of these findings on the health of an aging population.

At the University of Arizona, SENS Research Foundation is funding proof - of - concept research to restore the health of the immune system in aging mice, by simultaneously increasing the ability to produce new killer T - cells while making room for them by purging defective cells from the system.

These analyses revealed some of the same effects of rapamycin in young mice as in aging mice (decreased CD25 + CD4 + T cells; Figure 9C), whereas other effects were not present (no decrease in CD44hi T cell frequency; Figure 9E).

Higher serum levels of pro-inflammatory factors such as interleukin - 6 and tumor necrosis factor are found in aged mice.

Development of diet - induced fatty liver disease in the aging mouse is suppressed by brief daily exposure to low - magnitude mechanical signals

Peripheral T cell diversity is virtually constant in the young, but is invariably reduced in aged mice and humans.

Rapamycin suppressed carcinogenesis in aging mice.

c - Fos imaging of testing - induced brain activations showed that the deterioration of young memory was associated with dentate gyrus dysconnectivity, reminiscent of that seen in aged mice.