Sentences with word «ligand»

In addition, at least some Eph receptors can also signal through non-canonical mechanisms that are independent of ligand binding and kinase activity, for example through interplay with other receptor tyrosine kinase families and with serine / threonine kinases.

With Ligand Pharmaceuticals (NASDAQ: LGND), an owner of royalty assets in the biotech space, you get both.

We could unambigously demonstrate that dimerization of the receptor subunits is induced by ligand binding.

She and her staff measure the effects of kappa - opioid receptor ligands on acute cocaine reward and on withdrawal from binge cocaine treatments using intracranial self - stimulation.

The networks provide structural integrity to tissues and serve as ligands for integrin cell - surface receptors.

Investigate the roles of protein antigen and Toll - like receptor ligands in activating the ER stress response to promote leukemic progression

MOFs are microscopic - scale porous crystals engineered from metal ions bound together by organic molecules called ligands.

Shares of Ligand Pharmaceuticals shed nearly 12 percent Tuesday after Amgen said its multiple myeloma drug, Kyprolis, did not outperform Takeda Pharmaceutical's Velcade in a late - stage study.

EOS884448 binds to human TIGIT and prevents binding of natural ligand at sub-nanomolar concentrations

We then tested the response of transgenic plants with the sensing and de-greening gene circuits to the TNT ligand using conditions that mimic real - world situations.

The effect of stress - induced ligands on testosterone formation in Leydig cells.

AstraZeneca's investigational anti-PD-L1 immune checkpoint inhibitor, durvalumab, targets the programmed cell death ligand PD - L1, which helps tumors go undetected by the immune system.

«switchSENSE ® gives researchers new tools to understanding protein - ligand interaction by combining traditional kinetics measurements with changes in molecular size and shape.»

In March 2016, the Felsher lab at Stanford University reported that in a mouse model of T - cell acute lymphoblastic leukaemia (T - ALL), MYC up - regulates the «invisibility» ligand PD - L1, thwarting the immune response to the cancer.

Delaney et al. [4] who have shown that cord blood - derived CD34 + cells cultured in StemSpan ™ medium with cytokines, on plates coated with Notch ligand, are expanded ex vivo while still maintaining their ability to engraft into immunocompromised mice.

These nitrogen - containing ligands twist into three different isomers, which are different arrangements of the same atoms.

The lever can be easily modified with desired binding sites at its top end and along its flanks and hence can serve as a scaffold for the positioning of ligand molecules with nanometer accuracy.

High quality coating of magnetic silica beads with Steptavidin, Protein A, Protein G or other ligand specific molecules allows isolation of specific target molecules or cells out of large volumes or complex mixtures.

It yielded a polyoxocation of zinc, aluminum and chromium that is not protected by the organic ligand shell that is usually required to capture such molecules from water.

This approach is considered «passive,» as nanoparticles do not use ligands targeting specific epitopes on the cell surfaces.

Subsequently, he established carbon monoxide as another gaseous transmitter and D - serine as a glial derived endogenous ligand of glutamate - NMDA receptors.

This level of observation of either the proteins or protein - ligand complexes makes crystallography one of the most advanced and promising approaches to new drugs discovery.

«Now that we know exactly which ligand produces which NMR signal, we can proceed with precise studies on how this nanocluster interacts with the chemical and biological environment in the water phase.

The key new finding by this team was to combine two existing techniques: making very tiny particles of iron oxide, and attaching certain molecules (called surface ligands) to the outsides of these particles to optimize their characteristics.

The ability to «thread» a molecular ligand through a metal - organic framework (MOF) to alter the pore size of the material — and yet allow the MOF to retain its crystallinity and principal structural features — has been demonstrated in a new study by A * STAR.

The lab has a particular interest in the trafficking of EGFR ligands in polarizing colonic epithelial cells.

Carmot is applying this approach to generate novel ligands for GPCRs and inhibitors of protein - protein interactions.

Computationally re-designed periplasmic binding proteins (PBPs) provide a means to design highly sensitive and specific ligand sensing capabilities in receptors.

(B) GUS induction in transgenic plants in response to increasing ligand concentration.

Binding to ephrin ligands on the surface of neighboring cells induces canonical signaling involving receptor clustering, autophosphorylation on tyrosine residues, and kinase activity - dependent downstream signaling.

HPP - 1014 is expected to act through Keap1 to stabilize Nrf2, while CoPP is a mimetic of heme, a known ligand for Bach1 that reduces its steady - state levels [20].

ADAMTS1 and MMP1 proteolytically engage EGF - like ligands in an osteolytic signaling cascade for bone metastasis

While these two ligands activate cellular receptors in the same way, they do so in different patterns over time.

Plant transformants typically showed ligand dependent induction.

Bone marrow cells have such ligands, so George and co-workers set out to see if they are involved in an assisted cellular suicide that helps organ transplants.

These killer cells, the most common type of brain cell, secrete a protein called Fas ligand.

Time / Date: Tuesday, October 20, 2015, 3:30 p.m. * Location: Room 206, Claxton Building, 1122 Volunteer Blvd. Speaker: Dr. Quentin Johnson, NIMBioS postdoctoral fellow Topic: Utilizing computational methods to predict allosteric networks in protein complexes Abstract: Allostery is a fundamental control mechanism used to regulate many biological processes that range from ligand binding to transcriptional activation.

First, the complex contains a shorter - than - expected metal - metal bond and, as desired, the metals are not supported by bridging ligands.

The Evans lab discovered a genetic switch through which vitamin D - related ligands such as calcitriol, a hormonally active form of the vitamin, can put the brakes on fibrosis.

However, I carried out a similar set of experiments utilizing follistatin transgenic mice, which demonstrated that these additional ligands do play a major role in suppressing muscle growth.

Given that Smad 1/5 are required for neurite growth induced by BMP ligands (Figure 2), we next sought to test the hypothesis that the miR - 181a inhibitor mediated Smad1 / 5 activation is responsible for the increase in neurite growth following miR - 181a inhibition.

Vedadi, M.; Niesen, F. H.; Allali - Hassani, A.; Fedorov, O. Y.; Finerty, P. J., Jr.; Wasney, G. A.; Yeung, R.; Arrowsmith, C.; Ball, L. J.; Berglund, H.; Hui, R.; Marsden, B. D.; Nordlund, P.; Sundstrom, M.; Weigelt, J.; Edwards, A. M. Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.

To function in plants, re-designed bacterial PBPs must be localized outside the plant cell to sense extracellular ligands, but be retained in such a way that they are able to activate transmembrane HKs.