Metagenomic sequences refer to all the genetic material, specifically DNA or RNA, collected from an environment rather than from a single species. It captures the combined genetic information of different microorganisms living together in a particular ecosystem, such as soil, ocean, or our own body. By studying
metagenomic sequences, scientists can explore the diverse and interconnected communities of microorganisms and gain insights into their functions, evolution, and impact on the environment.
Full definition
«The development
of metagenomic sequencing of the total DNA in a microbial sample from the human body has allowed us to estimate the abundance of specific microbes and microbial genes.
Scalable metagenomics alignment research tool (SMART): a scalable, rapid, and complete search heuristic for the classification of
metagenomic sequences from complex sequence populations — Aaron Y Lee — BMC Bioinformatics — 2016
In addition, one study has suggested the existence of an oceanic mitochondria affiliated clade (OMAC), based on
metagenomic sequence data of Craig Venter's global oceanic survey (GOS) expedition.
TFUMseq (Temporal
FUnctional Metagenomics sequencing) uses shotgun libraries cloned into a recipient bacterial species, tracked over time in gnotobiotic mice by deep sequencing and computational methods.
While sifting through
metagenomic sequence datasets for a U.S. Department of Energy Joint Genome Institute (JGI) Community Science Program project, researchers identified genome sequences typically found in giant viruses.
«Massive -
scale metagenomic sequencing of environmental DNA and RNA samples should, in principle, generate sequence data from any entity for which nucleic acids can be extracted,» Rubin noted.
This process has been initiated, predominantly for 0.1 — 0.8 - µm - sized surface ocean microbes, using data provided by the GOS expedition [22], [27], [32], [33], but will be dramatically extended here by sampling throughout the water column, across organismal size scales and
beyond metagenomic sequencing, tightly coupled to global ocean - modelling efforts.
Genome sequencing has become a powerful tool for studying emerging infectious diseases; however, genome sequencing directly from clinical samples without isolation remains challenging for viruses such as Zika,
where metagenomic sequencing methods may generate insufficient numbers of viral reads.
The goal of the pilot study is to successfully demonstrate the use of high -
throughput metagenomic sequencing technologies to characterize the gut microbiome and virome in this cohort.
We present Temporal
FUnctional Metagenomics sequencing (TFUMseq), a platform to functionally mine bacterial genomes for genes that contribute to fitness of commensal bacteria in vivo.
Identification of bacterial pathogens and antimicrobial resistance directly from clinical urines by nanopore - based metagenomic sequencing
Objectives: The introduction
of metagenomic sequencing to diagnostic microbiology has been hampered by slowness, cost and complexity.