Sentences with phrase «on autophagy»

Research on autophagy is a growing field because understanding the basic mechanisms of autophagy is key to understanding how cells sustain themselves and is a promising therapeutic target in several molecular pathologies especially in cancer and neurodegenerative diseases.

With a view to clinical studies (tests on humans) it is important to note that the effects on the tumor vasculature were even observed at chloroquine concentrations that had little effect on autophagy in the cancer cells.

Since Ras - driven cancers often rely on autophagy for growth and survival, this raised the question: Is proteome remodeling by autophagy important, and if so, by what mechanism?

Specific inhibition of Vps34 activity in the complex form might differentiate the effect on autophagy or endocytosis.

On the autophagy side of this complicated machinery, a key protein called LC3 was detected in the nucleus in earlier studies.

«Inhibition of these receptors with a low dose of the agent, LCB -03-110, or reduction of DDRs expression in several models of Parkinson's and Alzheimer's disease, allows nerve cells to switch on autophagy to clear toxic proteins and help the brain insulate itself from circulating inflammatory cells.

The studies on autophagy by Yoshinori Ohsumi, which earned him the Nobel Prize in Medicine in 2016, and the discovery of cell cycle regulatory genes for which Leland Hartwell, Timothy Hunt and Paul Nurse received the same award in 2001, including the research of Elizabeth Blackburn, Carol Greider and Jack Szostak on telomeres, telomerase and its protective effect on the chromosomes, were all made possible thanks to yeast.

The year Ohsumi and Tsukuda published their yeast screen, only a couple of dozen research papers were published on autophagy.

As mentioned above, pancreatic cancers and Kras - driven lung cancers are highly dependent on autophagy for tumorigenic development, whereas other types of cancers might only use autophagy as a cell survival mechanism when stressed.

Specifically, i am wondering if this would have an impact on autophagy?

VIDEO — Dr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation

Since mTOR is a potent inhibitor of autophagy (mTOR acts like a brake on autophagy), blocking mTOR increases autophagy (ie.

However, just as the post on autophagy showed the vast benefits of putting our body into recycling mode, there are also some negatives that we should be aware of before entering the world of fasting.

The prize in physiology or medicine went to Yoshinori Ohsumi at the Tokyo Institute of Technology for his work on autophagy, the process by which cells recycle and repair themselves.

The 2016 Nobel prize for medicine was awarded to Japanese scientist Dr. Yoshinori Ohsumi for his research on autophagy, a process that occurs during fasting.

This year's Nobel Prize in Physiology or Medicine has been awarded to Yoshinori Ohsumi, a cell biologist at the Tokyo Institute of Technology's Frontier Research Center, for his work on autophagy, the process in which cells degrade and recycle cellular components.

Cell biologist Yoshinori Ohsumi of the Tokyo Institute of Technology has received the prize for his work on autophagy, a method for breaking down and recycling large pieces of cellular junk, such as clusters of damaged proteins or worn - out organelles.

Cell biologist Yoshinori Ohsumi becomes sole winner of the 2016 Nobel Prize in Physiology or Medicine for his work on autophagy

The prize was for his work on autophagy, a kind of cellular housekeeping that helps clear the cell -LSB-...]

And I convinced him to start a side project on autophagy in the immune system, so we now have a grant on autophagy and aging related to stress.

The prize was for his work on autophagy, a kind of cellular housekeeping that helps clear the cell of damaged proteins and other potentially toxic debris.

VIDEO — Dr. Yoshinori Ohsumi at the Tokyo Institute, who has received the 2016 Nobel Price on his research on Autophagy The report starts 3 min into the video

These are all food for thought, and while the data is increasing by the minute, much of the work on autophagy is still science mixed with theory.