Sentences with phrase «programmed cell death»

The viruses take advantage of the process that normally occurs during programmed cell death.

This drug is then free to bind to receptors in the tumor cell's membrane, triggering programmed cell death.

Often these mutations make the cancer cells resistant to normal programmed cell death, and the cells will divide over and over, forming a solid tumor.

Every exposure to radiation poses health risks, including programmed cell death, genetic mutations, cancers, leukemia, birth defects, and reproductive, immune and endocrine system disorders.

After graduating, he went to the University of California, Davis, and settled on investigating the genetic regulation of programmed cell death in plants.

Checkpoint inhibitors are monoclonal antibodies that target certain proteins that downregulate the immune system, such as programmed cell death protein 1 (PD - 1), programmed death - ligand 1 (PD - L1) and cytotoxic T - lymphocyte antigen 4 (CTLA - 4).

If this fails, the UPR instructs the cell to self - destruct, a process known as programmed cell death or apoptosis.

They are heavily involved in cellular metabolism as well as in apoptosis, the process of programmed cell death by which potentially cancerous cells can be killed before they multiply and spread.

Vazquez's laboratory experiments have shown that cosmic rays induce what is called programmed cell death in neurons.

Once activated, the mechanism for programmed cell death shrinks the cell's nucleus, decreases the cell's fluid, or cytoplasm, and snips up the cell's DNA.

CAMBRIDGE, Mass. — A long non-coding RNA (lncRNA) regulates programmed cell death during one of the final stages of red blood cell differentiation, according to Whitehead Institute researchers.

The Caenorhabditis elegans Bcl - 2 — like protein CED - 9 prevents programmed cell death by antagonizing the Apaf - 1 — like cell - death activator CED - 4.

Downregulation of tumor suppressors and upregulation of proto - oncogenes can directly inhibit the ability of a cell to undergo programmed cell death while simultaneously stimulating growth and division.

Without such programmed cell death, we would all be born with webbed feet, like ducks.

This occurs because cells without CEP63 have delayed cell division, leading them to enter programmed cell death through p53.

«We want to understand axonal degeneration at the same level that we understand programmed cell death, in the hopes of developing drugs to block the process when it becomes overactive,» DiAntonio says.

So the shark - specific signature of adaptation found in the Bag1 gene may indicate an alternative, or modified role for this important gene — one that could alter its tendency to inhibit programmed cell death in sharks.

In 2008, the structural biologist turned down a $ 10 million grant from the Howard Hughes Medical Institute in Chevy Chase, Maryland, for his work on programmed cell death and relinquished an endowed chair at Princeton University to relocate to Beijing, because, he says, he felt he could «play a much more important role in a rapidly transforming country.»

Because programmed cell death goes awry in leukemias and other cancers, Hu is currently examining lincRNA - EPS's function in normal and diseased human cells in an effort to determine whether it plays a role in tumor development and growth.

These vegetables help block estrogen, the fiber helps you excrete excess estrogens, and overall the crucifers help cells with programmed cell death, so that senescent cells don't keep circulating and loitering like zombies, wreaking havoc and accelerating the aging process.

Most are destroyed by the immune system or their own programmed cell death mechanisms, but enough linger for the long term for their growing presence to be one of the contributing causes of the aging process.

«Liver cancer due to chronic inflammation: Tumor growth follows programmed cell death (apoptosis).»

Neural crest cells that should ordinarily have succumbed to programmed cell death escape that fate when KIF1B - β is lost.

«Presumably, once induced, autophagy promotes desiccation tolerance in the grass, by recycling nutrients and removing cellular toxins to suppress programmed cell death.

«Immune 1 -2-3 punch against parasites reveals potentially ancient cell death pathway: «Microptosis,» which resembles programmed cell death in animal cells, could present an antimicrobial drug development opportunity.»

Now a team of UCLA researchers has discovered that a subset of tumor cells that don't produce the protein CA125, a biomarker used to test for ovarian cancer, has an enhanced ability to repair their DNA and resist programmed cell death — which allows the cells to evade the drug and live long enough to regrow the original tumor.

For example, microRNA - 96, which was the target of the new study, promotes cancer by discouraging programmed cell death, which can rid the body of cells that grow out of control.

Results showed decreased production of microRNA - 96 and increased programmed cell death, significantly reducing tumor growth.

The study, published by the journal Proceedings of the National Academy of Sciences, demonstrates that the Disney lab's compound, known as Targaprimir - 96, triggers breast cancer cells to kill themselves via programmed cell death by precisely targeting a specific RNA that ignites the cancer.

«The idea that the host triggers the mechanism of [programmed cell death] as a way of defending against infection is very cool,» says Borna Mehrad, a pulmonologist at the University of Florida College of Medicine in Gainesville who wasn't part of the study.

That suggested that neutrophil activity might set off fungal programmed cell death.

In mice, when white blood cells in the lungs engulf spores of a common airborne fungus, these immune cells release an enzyme that sends the fungal cells into programmed cell death.

Similarly, the recent successes to directly stimulate the immune system with inhibitors of negative immune checkpoint regulators — such as antibodies against programmed cell death protein 1 (PD - 1) or its ligand PD - 1 — has led to many clinical trials.

In this case, the trigger is a drug that interacts with the protein produced by the «suicide gene,» which metabolizes it into a form deadly to the cell, causing it to commit programmed cell death (apoptosis).

Cancer Center investigators demonstrate that topoisomerase inhibitors induce programmed cell death in leukemia cells.

Dr. Altieri also leads a research program that studies how tumor cells evade programmed cell death and the role of mitochondria, power plant of the cells, in tumor metabolism.

After further investigation, Hu found that lincRNA - EPS inhibits the expression of Pycard, a gene that promotes programmed cell death, explaining in part lincRNA - EPS's role in apoptosis prevention.

Programmed cell death monitors the growth of new cells and the elimination of old ones.

This is the first time a lncRNA has been found to play a role in red blood cell development and the first time a lncRNA has been shown to affect programmed cell death.

A tomato 14 -3-3 protein (TFT7) positively regulates immunity - associated programmed cell death mediated by diverse disease resistance proteins

It promotes tumor cell proliferation and resistance to apoptosis (programmed cell death after a certain number of cell divisions, a good thing when it comes to cancer cells).

Previous studies show that antibody treatments that inhibit the protein, called programmed cell death 1 (PD - 1), can shrink tumors in humans.

Cells that detach from their environment undergo a form of programmed cell death called anoikis.