Sentences with phrase «regulatory sequences»

Our computational biology research is focused on genome analysis, with an emphasis on the identification and characterization of regulatory sequences controlling the transcription of genes.

The researchers looked at mutation rates in likely regulatory sequences of rat and mouse genomes.

They also demonstrated significant advantages of editing gene regulatory sequences in their native location to uncover new functionalities that could lead to a better understanding of how control switches work to turn genes on and off in the body.

Identification of cis - regulatory sequence variations in individual genome sequences.

It is proposed that NF - A3 represses specific regulatory sequences that contain the octamer motif.

Cell identity is specified by the coordinated action of transcription factors, which bind to specific DNA regulatory sequences and turn gene expression on.

As you said it is an extremely small number of differences that you find genetically between humans and chimps, but it is an extremely important one, and what seems to make it so important is that a lot o these differences seem to affect what are in effect regulatory sequences.

The specificity of this regulation originates in the binding interactions between special regulatory proteins, called transcription factors (TFs), and short regulatory sequences on the DNA, called binding sites.

The problem is that they insert genes at random locations in the genome, as well as inserting regulatory sequences that can sometimes activate nearby genes and trigger cancer.

«We looked inside the shared regulatory sequences and found mouse and human genomes to have a common language in regulation, but that there is a tremendous amount of flexibility in evolution.

Now that we have sequenced these additional nematodes, we can compare the sequences to discover new regulatory sequences and motifs.»

Gene Evolution and the Origins of Novelty The evolution of regulatory sequences appears to be the major mechanism underlying the evolution of animal form.

The interaction of chromosomes and mobile DNA elements (transposons) has rearranged genes, shuffled regulatory sequences, mobilise genes to new locations and added new genes to plants.

We have identified one such instance in a bifunctional yeast gene where gene duplication enabled the two functions to become independently encoded and regulated and where most of the adaptive divergence between the two duplicates involved regulatory sequences.

The authors designed an electromobility shift assay (EMSA) to examine how the missense substitution affected PAX7 «s ability to bind a target regulatory sequence.

In many imprinted genes, regulatory sequence elements have been identified that are methylated on one of the parental chromosomes only.

At present we are engineering regulatory sequences to direct gene expression selectively to target cells and tissues in the CanEuCre / Pleiades Promoter Project.

Second, the lab collaborates internationally on the analysis of emerging data, such as an international FANTOM project to map regulatory sequence positions through the study of the 5» end of RNA transcripts.

He argues that whole genomes will not only provide more data for building trees, but will also enable researchers to study the evolution of regulatory sequences, transposable elements, and other aspects of the genome that are not covered with OpenWings sequencing.

The gene regulatory sequences in the SeLS construct were improved from our initial SeLSX and SeLSM35 constructs, allowing greater accumulation of cyanobacterial Rubisco and improved growth.

More recently, it has become clear that slight variations in the regulatory sequences that determine when a gene is switched on,...

Fortunately only about 3 percent of that is actual genetic information that gets translated into proteins; the rest is regulatory sequences, old, nonfunctioning genes, or outright nonsense.

Another experiment looked at Arabidopsis containing a reporter gene called GUS that was fused to the regulatory sequences of the cytokinin receptor genes.

The findings are especially important as they highlight the discovery of a regulatory sequence, termed the J element, that controls class I gene expression of many more genes than the counterparts that regulate class II gene expression.

They found that these regulatory sequences had acquired fewer mutations than had sequences thought to mutate at the genome's baseline rate.

The study also established that the risk variation of the melatonin receptor 1A (MTNR1A) gene is probably related to the methylation of DNA in the regulatory sequence of the MTNR1A gene as well as the weaker expression of the MTNR1A gene.

Our future work aims to uncover the molecular mechanisms linking transcription status of large genes to the organization of chromatin loops by their regulatory sequences, and how these features impact the setting of replication origins and CFS instability.

Most importantly, this body of work has uncovered some of the first direct evidence for the central role of changes in gene cis - regulatory sequences in the evolution of body plans and body parts and in the origin of new structures and pattern elements.

Our findings suggest that coding sequences and regulatory sequences that harbor more than one function may require duplication in order for an individual function to evolve.

The pervasive role of cis - regulatory sequence evolution in the evolution of morphological traits has raised a host of new questions about the process of regulatory evolution.

However, several genetic mechanisms — including the evolution of protein - coding sequences and gene duplication, as well as the evolution of regulatory sequences — are sources of variation in all species and contribute to organismal adaptation.

Any number of regulatory sequences, including protein enhancers and repressors, can be included in the repair template for inducible alteration of protein expression levels.

This process, called genomic DNase I footprinting, makes for a clever system of isolating isolating cis - regulatory sequences, and is nicely illustrated in this figure:

However, this phenomenon clearly occurs less frequently with naturally occurring pseudogenes, which probably reflects a parallel degeneration of their regulatory sequences.

Using high - throughput ChIP - Seq and chromatin property data, we are developing a new generation of bioinformatics methods for the identification of regulatory sequences.

A new paper in Nature Genetics finds that people with common migraine tend to have a mutation in a regulatory sequence for genes that control glutamate abundance.