Sentences with word «rosiglitazone»

«Previous studies had tested the use of rosiglitazone for cancer treatment, but the outcome was not encouraging.

Studies have found that mango has glucose and cholesterol - lowering properties, which compare to the effectiveness of the commercially used drug rosiglitazone, but without its side effects.

Prolonged decrease of adipocyte size after rosiglitazone treatment in high - and low - fat - fed rats.

Furthermore, rosiglitazone increased mortality in those with type 2 diabetes [34].

Pini M, Rhodes DH, Castellanos KJ, Cabay RJ, Grady EF, Fantuzzi G. Rosiglitazone improves survival and hastens recovery from pancreatic inflammation in obese mice.

Klotho is a secreted protein that can be measured in the serum of patients and this can help in determining which patients would benefit from rosiglitazone therapy and would be eligible for further studies.

Among other things, PPAR - gamma regulates the uptake of glucose in fat cells, and rosiglitazone targets the protein in these cells to improve glucose uptake in people with type 2 diabetes.

The new studies were led by researchers who have long voiced concerns about Avandia, also known by its generic name rosiglitazone.

Although both studies have limitations, an editorial accompanying Graham's paper considered the findings compelling: «Accumulating concerns about rosiglitazone make it difficultto advance a cogent argument regarding why, exactly, a patient might want to receive the drug.»

We've got rosiglitazone [Avandia] being questioned.

Differential Effects of Rosiglitazone on Skeletal Muscle and Liver Insulin Resistance in A - ZIP / F - 1 Fatless Mice

«Our post-trial analysis compared patients treated with rosiglitazone to patients not receiving any TZD drug.

«It's not a pure randomly assigned trial of rosiglitazone versus a different drug,» Bach says.

In 2010, the U.S. Food and Drug Administration (FDA) restricted rosiglitazone's use because of questions about cardiovascular safety.

There is particular controversy surrounding rosiglitazone.

Rosiglitazone also improves insulin sensitivity and is known to move free fatty acids out of the blood.

But women, already benefiting from metformin, improved heart metabolism further by adding rosiglitazone, with the desired effect of reducing the heart's dependence on fat metabolism.

Peri-ovulatory Rosiglitazone treatment reverses impaired embryo development associated with obesity.

Rosiglitazone prevents the rise in net cell death.

Effect of chronic rosiglitazone, metformin and glyburide treatment on beta - cell mass, function and insulin sensitivity in mZDF rats.

The only thing rosiglitazone drugs like Avandia do is to help lower blood glucose, which has virtually no influence on the long - term damage due to type 2 diabetes.

Twenty - four independent experts reviewed the available data and concluded that rosiglitazone indeed increased the risk.

AVANDIA (rosiglitazone maleate) is an oral antidiabetic agent which acts primarily by increasing insulin sensitivity.

The researchers showed that the type 2 diabetes drug rosiglitazone, which increases insulin sensitivity, also protects neurons from ADDLs.

Unexpectedly, rosiglitazone increased the risk of heart attacks.

By 2011, Europe, the UK, India, New Zealand and South Africa had all banned the use of rosiglitazone, although the FDA continued to allow its sales in the United States.

The team found that the white wines had low binding affinities, but all the reds bound readily: the tendency of 100 millilitres of red wine — about half a glass — to bind to PPAR - gamma is up to four times as strong as the same tendency in the daily dose of rosiglitazone (Food and Function, DOI: 10.1039 / c0fo00086h).

They also showed that they could manipulate Klotho expression pharmacologically using the anti-diabetic drug rosiglitazone, which resulted in decreased levels of Wnt5A.

Importantly, while using rosiglitazone in conjunction with targeted therapy reduced tumor growth in both young and aged pre-clinical models, using rosiglitazone alone accelerated tumor growth in young models, while inhibiting it in aged ones.

So Alois Jungbauer and colleagues at the University of Natural Resources and Life Sciences in Vienna, Austria, tested 10 reds and two whites to find out how strongly the wines bind to a protein called PPAR - gamma, which is targeted by the antidiabetic drug rosiglitazone (marketed as the controversial Avandia).

The researchers showed that a two - day treatment regimen with partial or selective PPAR - γ agonists (Telmisartan and Rosiglitazone — both FDA - approved drugs) ameliorated the pathological outcomes of infection in mice by inducing expression of glucose transporters.

A study in the May issue of The New England Journal of Medicine that combined data from 42 separate clinical trials found that rosiglitazone (Avandia) boosted the risk of death by 64 percent.

In these mouse tests, WWL113 — without any optimization for use as a drug — performed about as well as the FDA - approved diabetes treatment rosiglitazone (Avandia).

The drug, whose generic name is rosiglitazone, has been under scrutiny since 2007 for possibly increasing the risk of heart attacks.

Notably, the new compound lacked one of the side effects that drugs in rosiglitazone's class have in mice: the toxic accumulation of lipids in the liver.

The latest case concerns GlaxoSmithKline's Avandia (rosiglitazone), an anti-diabetes drug linked to heart attacks.

Clinical trials of GlaxoSmithKline's diabetes drug Avandia (rosiglitazone) and Merck's anti-inflammatory Vioxx (rofecoxib) revealed an elevated cardiac risk from the drugs, but relevant findings were held back from regulators or never published.

However, it is commonly associated with diabetes, which has prompted researchers to test diabetes medications, such as metformin, rosiglitazone and liraglutide, as potential treatments.

Combined effects of rosiglitazone and conjugated linoleic acid on adiposity, insulin sensitivity, and hepatic steatosis in high - fat - fed mice.

When BubR1H / H; INK - ATTAC mouse bone marrow cells were pushed into senescence in vitro by the PPAR - γ - activating drug rosiglitazone, a subpopulation of the cells exhibited high levels of INK - ATTAC expression and GFP, coupled with SAβ - gal staining; subsequent to treatment with the INK - ATTAC activating drug, these cells rapidly entered into apoptosis, and within 48 h were either destroyed or in the cell death process.

Taking either rosiglitazone or Lovaza with metformin seemed to mitigate some of the negative heart effects of metformin alone in men.

Under McGill's supervision, the first group received metformin alone; the second received metformin plus rosiglitazone (Avandia); and the third received metformin plus Lovaza, which is a kind of fish oil.

The diabetes drug rosiglitazone has been under intense scrutiny since a 2007 study in the New England Journal of Medicine looked at more than 40 clinical trials and linked the drug's use with increased risk of heart attack and death from heart disease.

Glucosamine may also interact with acetaminophen; agents applied to the skin; agents eliminated by the kidneys; agents for the stomach or intestines; agents that increase sun sensitivity; agents that may increase urine flow; alcohol; anticancer agents; antidepressants; anti-hemorrhage agents; caffeine; chitosan; doxorubicin; etoposide; nicotine; nonsteroidal anti-inflammatory drugs (NSAIDs); pain relievers; rosiglitazone; teniposide; thiazolidinediones.

Metformin is also sold under the brand names Glucophage and Glucophage XR, and is found in pills that combine two types of antidiabetes medication, such as Glucovance and Metaglip (which combine metformin with a sulfonylurea drug) and Avandamet (a combination of metformin and rosiglitazone, a thiazolidinedione medication).

The researchers found that berberine performed as well as three well - known diabetes drugs — metformin, glipizide and rosiglitazone — and also helped to lower LDL cholesterol and triglycerides.

Pills to control blood sugar in people who have diabetes — like Avandia (rosiglitazone) or Actos (pioglitazone)-- make it harder to get sodium out of the body, which leads to swelling.

Thiazolidinediones (Actos / Pioglitazone, Avandia / Rosiglitazone)-- These medications do lower insulin resistance.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.