Sentences with phrase «tumor mutations»

«The good news is that we discovered that a subset of patients who had both high tumor mutation burden and high PDL - 1 positive status did experience a significant benefit from immunotherapy,» says Carbone.

Patients with both high tumor mutation burden and high PDL - 1 positive status had a 75 percent response rate compared with a 16 percent response rate to immunotherapy among patients with low mutation burden and low PDL - 1.

«First - line immunotherapy treatment can improve survival for subset of lung cancer patients: Results of phase III global clinical trial show that 75 percent of stage IV lung cancer patients with both complex tumor mutations and PDL - 1 positive status respond to nivolumab.»

«This study is an important step toward understanding the impact of tumor mutation burden and PDL - 1 in immunotherapy response.

Hear about the use of bioinformatics workflows in a translational setting for tumor mutation detection

«Tracking defects caused by brain tumor mutation yields insight to advance targeted therapy.»

The researchers also employed tumor - marker testing by genotyping patient samples to pinpoint tumor mutations and tumor type.

His team has recently reported that melanoma and lung cancer patients with more neoantigen - coding tumor mutations are more likely to respond to immune checkpoint blockers.

The study further suggests that NSAIDs such as aspirin, ibuprofen and naproxen have a particularly advantageous effect when taken after diagnosis by colorectal, or CRC, patients without tumor mutation in the KRAS gene (KRAS wild - type tumors): The study shows that NSAID use by this group is associated with a survival benefit of 40 percent.

Their next steps are to characterize how these treatments affected NK cell function as well as determine the reactivity of patients» T cells against tumor mutations.

[66,67] Although responses were highly variable, patients with mutations more frequently achieved a clinical response than did those with amplifications, and patients with tumor mutations affecting exons 11 and 13 were able to achieve significant radiographic responses in over 40 % of cases.

He says such a method can potentially be used for CTC sorting from patient blood samples, CTC concentration monitoring, therapeutic guidance and drug dosage choice, and further study of tumors, such as drug screening and tumor mutations.

A team of investigators led by researchers at Georgetown Lombardi Comprehensive Cancer Center has found that the tumor mutation load (TML) in a patient's cancer biopsy varied by age and the type of cancer.

In light of these realizations, the long - term scientific goal of the program is to develop a detailed and mechanistic understanding of not just the tumor cell and tumor mutations, but also all the components of the host microenvironment that influence cancer and the response to cancer therapy.

The field of oncology is moving away from toxic chemotherapies and more toward medicines targeted to tumor mutations and treatments that rev up the immune system.