Sentences with phrase «tumor profiling»

Single - cell DNA solid tumor profiling enables high resolution of the genomic diversity in a variety of tumor types.

The study showed that despite the risk for receiving information about other potentially serious health problems, 59 % of the cancer patients would agree to tumor profiling if offered by their physician.

In a scenario where tumor profiling was already ordered, 79 % of patients stated they wanted to know all of the information obtained.

Just over half of patients in the study who gave consent and had tumor profiling ordered by a physician actually received results, due to a variety of technical and logistical factors.

One project involves probing Foundation Medicine's growing database of tumor profiles for specific mutations and using that information to either design drugs or to parse patients into clinical trials of the company's drugs, says Pao.

Most cancer patients would opt for tumor profiling even if the test revealed that they or their families were at risk for other genetic diseases, according to a Yale Cancer Center study.

Published online by JCI Insight, it is the first report of «clinical implementation of tumor profiling in an enterprise - wide, unselected cancer patient population,» according to the authors.

Researchers leading the largest genomic tumor profiling effort of its kind say such studies are technically feasible in a broad population of adult and pediatric patients with many different types of cancer, and that some patients can benefit by receiving precision drugs targeted to their tumors» mutations or being enrolled in clinical trials.

A. Establish a network for direct patient involvement Engage patients to contribute their comprehensive tumor profile data to expand knowledge about what therapies work, in whom, and in which types of cancer.

Increasingly sophisticated tumor profiling technology has led to advancements in diagnosing and treating genetic diseases like cancer.

«Most cancer patients want tumor profiling, even if it reveals other genetic risks.»

«While tumor profiling holds the promise of improved therapeutics through personalized medicine, it is important that both clinicians and patients discuss the possibilities of incidental findings prior to ordering the testing, as the findings can have serious implications for both the patient and their family members,» said Melinda Yushak, M.D., M.P.H., first author on the study and a medical oncology fellow in Yale School of Medicine.

In 2011, she joined the institution's molecular diagnostics laboratory where she has been developing translational next generation sequencing assays and bioinformatics workflows for the Molecular Tumor Profiling Lab of the Yale Cancer Center.

This confirmed the growing sense that tumor profiling based on only the primary tumor could lead to suboptimal or mistargeted therapy.

The study wasn't designed to measure whether tumor profiling made a difference in how patients fared, but «it nonetheless lays the groundwork for more systematic study of the impact of genomics on clinical practice and patient outcomes,» the report said.

Using tumor profiling to better understand how patients» tumors become resistant to cancer therapy

It has specialized workflows for both rare inherited disorders as well as somatic tumor profiling tests.

Yet overall the mutation rate in pediatric tumors was 14 times lower than that of adult tumors profiled by TCGA.

We combine the results with advanced bioinformatics to prioritize drugs that match your unique tumor profile.

A massive French database study shows that genetic tumor profiling in patients with non — small - cell lung cancer (NSCLC) is feasible, and is already helping physicians guide treatment in many patients, according to results presented at the American Society of Clinical Oncology annual meeting in Chicago.

The 15 AACR scientists, who were already in Washington, D.C., to meet with the U.S. Food and Drug Administration on genetic testing for cancer patients, tossed around ideas including expanding NCI's tumor genome - sequencing efforts and getting the government to cover the costs of genomic tumor profiling.

Our experts leveraged enormous amounts of tumor profiling data to identify the validated therapies that are most likely to be effective against this subtype of NSCLC.

Whether identifying rare subclones missed by standard bulk sequencing, or identifying co-mutation patterns in subclones, Tapestri Single - Cell DNA Panels can be applied across a wide number of applications, including hematologic malignancies, solid tumor profiling, and genome editing programs.

Using the newest molecular technology for tumor profiling, the project goal is to find cancer - driving mutations for every subset of lung cancer — even those seen in only 1 or 2 percent of lung cancer patients.

Tumor profiling can also reveal rare mutations and other changes that make some cancers unusually responsive to targeted drugs — knowledge that can be applied to patients with a variety of cancer types.

In 20 percent of cases, such mutations could inform treatment decisions, such as matching a patient's tumor profile to a targeted drug or improving the original diagnosis.

Additionally, whole genome sequencing is being used in cancer cases, both in tumor profiling and in ascertaining familial risk.