Sentences with word «calcineurin»

Dosage reduction may decrease toxicities; however, additional pharmaceutical drugs are often required to counteract the adverse effects of calcineurin inhibitor therapy.

For example, CRAC channels in T cells have been clinically validated as important drug targets through human mutations and the use of calcineurin inhibitors that act downstream from CRAC channels.

Newer non-steroidal medicines called calcineurin inhibitors are another option.

This is a significant finding because the loss of control of calcineurin signalling seems to play a role in many diseases, including neurodegenerative disease, cardiac disease and cancers.

The research team at Harvard Chan School used cutting edge genetic and cell biological methods to provide definitive evidence of the essentiality and function of calcineurin in parasite invasion.

«When we stimulated the calcium / calcineurin pathway in the presence of low levels of prostratin, we in turn boosted prostratin's effectiveness,» explained Dr. Chan.

In other words, too much RCAN1 results in not enough calcineurin activity.

• Proactive management includes the intermittent, but scheduled use of topical corticosteroids or topical calcineurin inhibitors to areas of the body that frequently have recurrent disease.

Studies from a group at the University of Glasgow, which are published in the same issue of the journal, show the importance of calcineurin through different stages of the malaria life - cycle, implicating the protein as a potential target for blocking malaria transmission.

«Patients using calcineurin inhibitors can potentially experience many adverse effects.

The team also demonstrates a general mechanism that can explain how calcium - dependent signalling by calcineurin is executed.

When sperm calcineurin (PPP3CC / PPP3R2) is blocked by CyclosporineA (CsA) or FK506, the midpiece remains rigid throughout epididymal transit.

They found that KIF1B - β affects the cells» power stations, the mitochondria, by activating an enzyme named calcineurin.

But this theory turns out to be wrong, because gag has no effect on calcineurin.

Insufficient calcineurin activity leads to impeded NGF functions and, thus, impaired peripheral nervous system development.

Scientists immediately wondered whether the HIV protein gag was mimicking cyclosporin A and affecting calcineurin.

By inactivating calcineurin the drug suppresses T cell activity.

Parasites with inhibited calcineurin failed to invade and were not infective.

«In addition to a possible drug target, calcineurin underlies a very basic aspect of parasite biology.»

For example, we discovered how the protein phosphatase calcineurin and its downstream effector protein NFAT act synergistically with the transcription factor MEF2 at transcriptional enhancer elements of selected genes, such as myoglobin, to medicate adaptive mechanisms by which skeletal myofibers acquire specialized contractile and metabolic properties in response to changing patterns of muscle contraction.

Pituitary adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: implication of calcineurin as a downstream target.

Hong - Gang Wang, PhD (D Club) Lois High Bestler Professor of Pediatrics and Pharmacology; Director, Pediatrics Molecular Oncology Program «Ca2 + induced apoptosis through calcineurin dephosphorylation of BAD» Science, April 1999 860 citations, Web of Science, April 1, 2017

Calcineurin B1 is essential for positive but not negative selection during thymocyte development

'' Dermatologist says: «Corticosteroids or calcineurin antagonists may be used to help reduce inflammation and itch.

The speaker woefully described his difficulties determining the structure of an immune system protein called calcineurin: Do what he might, one very large region of the protein simply refused to come into focus.

Topical calcineurin inhibitors (TCIs) are nonsteroidal medications that are applied to the parts of the skin affected by eczema.

Specifically, they showed how molecular crosstalk between calcium and an enzyme called calcineurin, along with a molecule called prostratin, switch on members of the NF - κB family of proteins — thereby activating latent HIV.

In the cohort of patients who received transplants from mismatched unrelated donors, all 43 patients received four doses of abatacept with a calcineurin inhibitor and methotrexate.

To serve as the control, researchers looked at data from a national database of matched patients receiving two commonly used regimens to prevent GvHD — a calcineurin inhibitor and methotrexate (CNI / MTX) or a calcineurin inhibitor and methotrexate plus anti-thymocyte globulin (+ ATG).

Phospho - RCS acted as a competitive inhibitor of CaM - dependent enzymes, including protein phosphatase 2B (PP2B, also called calcineurin).

The drug forms a complex with cyclophilin A and a third protein, calcineurin, which is needed to activate the T cells of the immune system.

This gene regulates a protein, calcineurin, that enables NGF to stimulate nerve growth and also support neuron survival.

In addition to opening the door to potential new malaria treatments, these studies suggest that calcineurin could be targeted to treat other parasitic diseases.

A new study led by researchers at Harvard T.H. Chan School of Public Health finds that a malaria parasite protein called calcineurin is essential for parasite invasion into red blood cells.

Researchers at Boston College working in collaboration with the Harvard Chan group showed that calcineurin is also important for cellular attachment by a related parasite that causes toxoplasmosis.

Human calcineurin is already a proven target for drugs treating other illnesses including adult rheumatoid arthritis and lupus, and the new findings suggest that parasite calcineurin should be a focus for the development of new antimalarial drugs.

We also characterized the function of a family of endogenous inhibitors of calcineurin, originally termed MCIP but subsequently renamed as RCAN proteins.

We are particularly interested in the calcineurin - NFAT pathway and mTOR pathway in immune signaling.

Schreiber's work on the FK506 - binding protein FKBP12 in 1988, along with his colleague Gerald Crabtree's discovery of the NFAT proteins, led to the elucidation of the calcium - calcineurin - NFAT signaling pathway.