Sentences with word «dystrophic»

In dystrophic RCS rats, threshold levels at P100 are greater than 3.0 log units above the background level of 0.02 log candela / m2.

In vivo gene editing in dystrophic mouse muscle and muscle stem cells.

Using a technique called proteomics to examine altered protein levels in muscle cells in mice, the team identified an enzyme protein called neutrophil elastase that was found to be more abundant in dystrophic muscle as compared to healthy muscle.

Confocal images of P150 dystrophic retina transplanted with hNPCctx — GDNF and double stained with antibodies against human nuclear antigen (red) and either (A) recoverin, a photoreceptor and cone bipolar cell marker (green), or (B) protein kinase Cα (PKCα), a bipolar cell marker (green).

Reyes lab began by treating old dystrophic mice with direct injection of THI.

No head - tracking response is observed in the 16 - week old dystrophic RCS rat during optokinetic testing of the right, non-transplanted, eye.

The distribution of occasional light - activated c - Fos cells observed in the GCL of non-transplanted dystrophic rats matches that reported for intrinsically light - responsive melanopsin ganglion cells [35].

(E) P150 dystrophic retina transplanted with hNPCctx — GDNF and stained with cone arrestin antibody showing morphology of rescued cone photoreceptors (arrows point to cone pedicles).

The progression of retinal dystrophy in the RCS rat is such that by 13 weeks post-graft most of the ONL has disappeared [33] and the photoreceptor outer segment layer is reduced to a debris zone [40], a finding we observed in dystrophic controls.

iPS - RPE cells were transplanted into dystrophic RCS rat eyes at three weeks of age, a time when retinal abnormalities are first observed.

Distant from the subretinal grafts, the ONL was reduced to a single layer at P100 and discontinuous, scattered cells at P150 (Figure 5G), similar to untreated and sham - treated dystrophic retinas.

In myotonic dystrophic patients, titration of MBNL protein by RNA containing expanded CUG repeats leads to expression of a fetal splicing form of the cardiac sodium channel, SCN5A, inappropriate to adult heart physiology, ultimately resulting in cardiac conduction delay and heart arrhythmias, which are two key features of myotonic dystrophy.

Fragile skin that blisters easily: 90 percent of the patients that suffer from the skin condition recessive dystrophic epidermolysis bullosa (RDEB) develop rapidly progressing cutaneous squamous cell carcinomas, a type of skin cancer, by the age of 55.

Later, the researchers simply added the compound to the drinking water in the habitats of young dystrophic mice.

Both De Luca and Marinkovich's teams are exploring a similar gene therapy for another major form of the disease, called dystrophic EB, caused by a different genetic error affecting a larger protein.

Twenty - one day old pigmented dystrophic RCS rats (rdy +, p +) received unilateral subretinal injections of hNPCctx (2 × 104/2 µl / eye)(n = 21), hNPCctx - GDNF (n = 11), or carrier medium only (n = 4)(sham surgery).

(C) Confocal image of P150 dystrophic inner retina transplanted with hNPCctx — GDNF and double stained with antibodies against nestin, a neural stem and progenitor cell marker (green) and human nuclear antigen (red).

Dystrophic epodermolysis bullosa, or DEB, is an inherited skin fragility disorder characterized by skin blistering, abnormal wound healing and excessive scarring, which often leads to aggressive skin cancer.

Four further dystrophic and 4 non-dystrophic (normal control) rats remained as unoperated controls.

Citation: Carr A-J, Vugler AA, Hikita ST, Lawrence JM, Gias C, Chen LL, et al. (2009) Protective Effects of Human iPS - Derived Retinal Pigment Epithelium Cell Transplantation in the Retinal Dystrophic Rat.

Conservation of visual acuity in the iPS - RPE transplanted eyes was associated with the preservation of photoreceptors in the host outer nuclear layer (ONL — Fig. 7A), identified by the expression of rhodopsin in the outer segments of photoreceptors (Fig. 7A inset, Dystrophic + transplant).

Mean visual acuity (± S.E.M.) of the transplanted eye versus control sham - injected eye and non-transplanted dystrophic eye.

Goudenege S, Lebel C, Huot NB, et al., Myoblasts derived from normal hESCs and dystrophic hiPSCs efficiently fuse with existing muscle fibers following transplantation.

Read the full article, «Branched fibers from old fast - twitch dystrophic muscles are the sites of terminal damage in muscular dystrophy,» published ahead of print in the American Journal of Physiology — Cell Physiology.

The autopsy concluded that the cause of death was dystrophic multiple organ failure.

Dystrophic causes of calcinosis cutis include idiosyncratic reactions to injections and other foreign materials.

Only occasional foci of c - Fos positive cells were detectable in the INL of the non-transplanted dystrophic retina where the ONL consisted of a single layer.

In this regard, loss of myostatin activity has been demonstrated to improve muscle mass and function in dystrophic mice [15]--[17] and to have beneficial effects on fat and glucose metabolism in mouse models of obesity and type II diabetes [18].

«VBP15 has an additional property of addressing membrane defects in dystrophic muscle cells,» remarked Kanneboyina Nagaraju, DVM, PhD, the lead author of the study, and principal investigator in the Center for Genetic Medicine at Children's National.

Host animals were 22 — 23 day old dystrophic (rdy − / p +) and non-dystrophic control, pigmented (rdy + / p +) Royal College of Surgeons (RCS) rats, which were maintained in a 12 h light / dark cycle.

Working in dystrophic mice while searching for a cure for Duchenne muscular dystrophy (DMD), Dr. Huard's laboratory team first identified a unique population of muscle - derived stem cells with the ability to repair muscle 8 years ago.

Sometimes, you may even worry your baby will become dehydrated or dystrophic.

Four different structural types of the disease are known: simplex, junctional, dystrophic and Kindler syndrome.

This finding helped specify the diagnosis as the dystrophic form of the recessive blistering disorder of the skin known as epidermolysis bullosa.

The study «Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation» is published in the journal Scientific Reports.

The species once had an astonishingly expansive historical distribution, occurring naturally in nutrient - impoverished, oligo - mesotrophic and dystrophic (humic) wetland systems in Australia, Africa, Asia and continental Europe (Cross, 2012a).

This approach has proved successful in disrupting multiple genes simultaneously in neurons and in editing the Dmdmdx mutation in muscle, thereby restoring dystrophin protein expression and partially alleviating the dystrophic muscles» functional deficiencies.

Topics such as the mechanisms of cell injury in normal and dystrophic muscle, compensatory muscle regeneration and hypertrophy, and the effects of various therapies or voluntary exercise on muscle repair, satellite cell activation, muscle growth, bone density and age - related atrophy are examined using a large variety of cellular, molecular and whole - animal in vivo assays of function.

We were unable to demonstrate the presence of amyloid plaques, dystrophic neurites, neuronal loss, macro - or micro-gliosis, aberrant cell cycle re-entry, oxidative stress, tau hyperphosphorylation, or upregulations of proinflammatory cytokines or stress signaling molecules in the retina.

Effect of genetic background on the dystrophic phenotype in mdx mice.

We used the head - tracking response to assess the visual function of RCS dystrophic rats 13 weeks after receiving a subretinal iPS - RPE transplantation in one eye only (Fig. 6 and Movies S2 and S3).

iPS - RPE cells were injected into the subretinal space between the host RPE and photoreceptor cells (B) A layer of iPS - RPE cells in the subretinal space of the dystrophic RCS rat 20 hours following transplantation.