For instance, one protein produced by a key
fruit fly gene serves two separate functions over the course of fly development.
The site's newest sections describe the growing number
of fly genes known to have close relatives in other animals, including humans — evidence, researchers are discovering, that the animal kingdom is interwoven genetically by its own worldwide web.
Collins and Anthony James of the University of California, Irvine, thought they might use the mutant bug to test a fancy trick: Take a bit of DNA, called a transposon, that likes to wiggle into genomes, and use it to insert a fruit
fly gene for darker eye color into a mosquito's DNA.
Now, he has another claim on immortality: Geneticists have named a newly discovered fruit
fly gene in his honor.
After moving to Berkeley, he arrived at a career crossroads in 1994, when Spyros Artavanis - Tsakonas, then at Yale, discovered and subsequently patented the human relative of the fruit
fly gene notch, which plays a role in cell - to - cell interactions and could be an anti-cancer target.
By tweaking
different fly genes and counting how many neuron types were produced as the flies matured, the team identified a network of five genes that work together like coordinated control switches to guide the precursor cells» transformation to mature neurons.
Sean Millard, a neuroscientist at the University of Queensland School of Biomedical Sciences in Australia,
researches fly genes that influence neuron spacing.
«Plants modified to express fruit
fly gene used to detoxify contaminated land.»
Researchers have found that a small change in a fruit
fly gene affects the frequency at which they sing to their mates, Ars Technica reports.
In the study, Spradling, with colleagues Michael Buszczak and Shelley Paterno, determined that the fruit
fly gene scrawny (so named because of the appearance of mutant adult flies) modifies a specific chromosomal protein, histone H2B, used by cells to package DNA into chromosomes.
Like the Wizard of Oz's man of tin, the
mutated fly gene, Bodmer discovered, led to a fly that lacked a heart.
Flies would never naturally have Alzheimer's, but
vinegar fly genes can be modified to bring it on.
Testing
on fly genes can tell us about humans ageing, immunity, diabetes, cancer and the effects of drug abuse.
«We've seen this kind of switch happen before as we compared families
of fly genes and families of human genes,» Shaw says.
They identified a mutation in a fruit
fly gene for a protein called S6 kinase, which helps control the production of ribosomes, the cell's protein - making machinery.
UNE researchers have discovered a dozen or so
fruit fly genes to target for the treatment of chronic pain.
Most of the rechristened genes were identified by geneticists studying the fruit fly; when equivalent genes were later found in the human genome, researchers simply continued using the name of the fruit
fly gene to avoid confusion.
Sidi Chen at the University of Chicago and colleagues found that about a third of fruit
fly genes are vital, regardless of when they appeared.
UCLA neuroscientist Larry Zipursky discovered this self - avoidance mechanism by studying
a fly gene called DSCAM1.
Dr Bruce added: «The next stage would be to put
the fly gene into the grasses, like we have done with the other RDX degrading genes.
When they screened other, similar fruit
fly genes, though, the scientists found one that did.
And we can use the powerful genetic tools already in place to study fruit
fly genes because so many fruit fly genes are conserved in humans and because fruit flies reproduce so rapidly.
September 1, 2006, Global Warming Shows Up in
Fly Genes, by JR Minkel.
In 2000, behavioral geneticist Ulrike Heberlein of the University of California, San Francisco, found that mutations in a fruit
fly gene that disrupts the synthesis of their version of the neurotransmitter noradrenaline dampen a fruit fly's ability to acquire tolerance to ethanol.
The Nkx2.5 gene is the equivalent of
a fly gene called «tinman,» which was discovered in 1993, by Ralph Bodmer, PhD, in the laboratory of Yuh Nung Jan, PhD, UCSF professor of physiology and biochemistry,.
«This is a case where scientists went from a fly mutation to
a fly gene to a human mutation that causes congenital heart defects,» said Stainier.