Sentences with phrase «gene segments»

While the cell is in the process of copying its genetic material, the new DNA would then replace a nearly identical existing gene segment in the cell, changing it slightly.

However, areas of low diversity around gene segments might also be produced by other evolutionary mechanisms.

«This unique approach will make it easier to evaluate how new mutations affect influenza pathogenicity and help to identify the underlying properties that enable or restrict influenza gene segment reassortment,» says Robert Daniels, the lead researcher from Stockholm University.

With the recent availability of the complete 1918 influenza virus coding sequence, we used reverse genetics to generate an influenza virus bearing all eight gene segments of the pandemic virus to study the properties associated with its extraordinary virulence.

Further, we have a keen interest in developing innovative methods for antibody modeling and design (Willis, J.; et al.; «Human germline antibody gene segments encode polyspecific antibodies»; PLoS Comput Biol; 2013; 9; 100304).

At the molecular level, RNA can bind DNA to deactivate gene segments, bind other RNA or it can bind proteins, activating or deactivating them.

It may be difficult to do taxonomy in the rapidly opening world of microorganisms, where bacteria routinely swap gene segments, he says, but the answer is not for scientists to throw up their hands.

It has multiple hosts and can evolve by mutation but also reassortment (when two closely related strains infect the same host and exchange gene segments, producing new strains — a process distinct from mutation, when the RNA of a virus is miscoded during replication).

Influenza gene segments visualized in cells during replication.

Background mutation rates by this method is ∼ 1 base - exchange per 1,000 bases sequenced (based on sequences of constant region gene segments).

Primers for PCR amplification of rDNA gene segments are in Additional File 3.

Of 38 other breeds examined, only Labrador cousins flat - coat retrievers were missing the same gene segment.

Human Antibodies From Synthetic Repertoires of Germline VH Gene Segments Rearranged In Vitro», Journal of Molecular Biology, 227: 381 - 388, 1992.

The study, co-led by Mats Nilsson (Stockholm University / SciLifeLab) provides new strategies for evaluating how new mutations affect pathogenicity and identifying properties that enable or restrict influenza gene segment reassortment that give rise to to new virus strains.

Therefore, NHEJ repair can only be used to create short genomic deletions, but does not support precise gene modification or the insertion and replacement of gene segments.

June's team also wants to knock out two gene segments that encode different portions of the protein that makes up a T cell's primary receptor so that the engineered NS - ESO - 1 receptor will be more effective.

By developing a new technique for labeling the gene segments of influenza viruses, researchers now know more about how influenza viruses enter the cell and establish cell co-infections — a major contributing factor to potential pandemic development.

The cell nuclei are in grey and the influenza gene segments are labeled as dots with a particular color.

The Münster immunologists found a test - tube alternative for this, too: they used the molecular biological method of genome editing to systematically «cut out» the gene segment relevant for VLA4 and produce the appropriate «deficient» immune cells.

Their genomes are composed of eight gene segments.

«You can make inferences, ideally, about what role each gene segment might have,» explains the Broad Institute's Yozwiak, «and that would be useful, but making larger leaps about its phenotype in people or any other reservoir species, that's a lot harder to do.»

From this they generated new cells in which the vector was integrated into any one of thousands of gene segments — with each segment glowing green when it was activated, or «switched on.»

The times to the most recent common ancestors for the Belgian and Australian G1P [8] rotaviruses ranged from 1846 to 1955 depending on the gene segment, with VP7 and NSP4 resulting in the most recent estimates.

The human T cell receptor beta (TRB, previously known as TCRB) gene locus on chromosome 7 (7q34) includes 65 Vb (variable) gene segments, followed by two separate clusters of genes each containing a Db (diversity) gene, several Jb (joining) genes, and a Cb (constant) region spread over 685 kilobases.

The NTRK fusions involved a gene segment encoding a tyrosine kinase domain.