Sentences with word «hemagglutinin»

The method is much less cumbersome than dealing with chicken eggs, and because the vaccine is so easy to produce, the company intends to use 135 micrograms of hemagglutinin in each dose of vaccine — 3 times higher than current flu vaccines — in hopes of getting better protection.

Wilson's laboratory used X-ray crystallography to determine the atomic structures of the H7N9 hemagglutinin protein bound to these sialic acid receptor molecules.

Of those, five were in the virus's hemagglutinin gene.

In the past two years, genetic sequence information of the flu - virus protein hemagglutinin from only two influenza strains from India has been deposited into publicly available influenza databases, making it difficult to determine exactly which strain is causing the new outbreak, and how it differs from previous strains.

The 11 - page study, led by Yoshihiro Kawaoka of the University of Wisconsin, Madison, and the University of Tokyo, describes how the research group stitched a mutated version of a key viral protein called hemagglutinin from the bird flu virus known as H5N1 onto the human H1N1 virus that caused a relatively mild pandemic in 2009.

Other researchers have stabilized the stalk by attaching a new hemagglutinin head — a lollipop flavor that the human immune system has never tasted.

ǂ «A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen» by Impagliazzo et al. published in Science on Monday 24th August.

«There are 16 different hemagglutinin subtypes that circulate in birds and are thought to be the basis for current and future influenza pandemics,» said Dr. Taubenberger.

Smith says the team traced the source of influenza by homing in on hemagglutinin, a protein on the surface of the virus that triggers an immune response in our bodies.

The researchers are taking hemagglutinin mutations from every flu strain that has ever circulated, dumping them into a kind of scientific blender and attaching them to particles that can form the basis of a vaccine.

This image from the work shows the binding of avian - like glycan receptors (yellow spheres) to the 2013 H7N9 influenza virus hemagglutinin (in ribbon diagram).

In 1980 Fiers first sequenced the gene for hemagglutinin derived from the human influenza strain H3N2 that circulated in 1965.

Influenza infection begins when hemagglutinin binds to receptors on the host cell.

To gain access to host cells, the virus uses a surface protein known as hemagglutinin which, like a key to a lock, opens the cell to infection.

The immune system commonly makes antibodies against hemagglutinin that foil the strain's ability to infect the host again.

As an example, Harrison is trying to use EM to investigate interactions of human antibodies with the influenza hemagglutinin glycoprotein.

In this case, researchers from the Icahn School of Medicine at Mount Sinai in New York City took tops from two flu strains that circulate only in birds, and connected each one to a human hemagglutinin stalk.

Lisa A. Jackson, M.D., M.P.H., of Group Health Research Institute, Seattle, and colleagues randomly assigned 980 adults (19 through 64 years or age) to receive the H7N9 vaccine on days 0 and 21 at doses of 3.75 µg, 7.5 µg, 15 µg, and 45 µg of hemagglutinin with or without AS03 or MF59 adjuvant.

In the new study, researchers at the NIAID used a virus - like particle vaccine cocktail that expressed a handful of different subtypes of a key surface protein of the influenza virus: hemagglutinin H1, H3, H5 and H7.

These triple - mutant H7 hemagglutinins also successfully latched onto cells in samples of human trachea tissue.

In their experimental treatment, he and his colleagues injected mice, ferrets, and monkeys with viral DNA, causing their muscle cells to produce hemagglutinin, a protein found on the surface of all flu viruses.

Some background: the head region of the flu virusâ $ ™ s mushroom - like hemagglutinin protein is more variable, and more exposed to the immune system, while the stem / stalk region is less variable.

Hemagglutinin then performs some molecular gymnastics.

«Almost all of the animals that were vaccinated survived, including mice that were challenged with viruses that expressed hemagglutinin subtypes that were not in the vaccine at all, viruses that expressed H2, H6, H10, and H11,» said Dr. Taubenberger.

This selection also provided a broad representation of hemagglutinins across the phylogenetic tree.

Any of the other 13 [hemagglutinin, or resistance - response, subtypes] has the potential to spark a pandemic.

The unaltered hemagglutinin is akin to a key that unlocks a so - called receptor molecule in cells lining the upper airways of humans and other mammals.

Ivan Kosik of the National Institute of Allergy and Infectious Diseases, Maryland, and colleagues investigated hemagglutinin mutations to better understand the mechanisms by which influenza A viruses maintain fitness despite continual mutation.

Hemagglutinin attaches to human cells to launch an infection; neuraminidase is more important for spreading the virus once infection has occurred.

After 2 doses of an H7N9 formulation containing 15 µg of hemagglutinin given without adjuvant, with AS03 adjuvant, or with MF59 adjuvant, the proportion achieving an hemagglutination inhibition antibody (HIA) titer of 40 or higher was 2 percent without adjuvant (n = 94), 84 percent with AS03 adjuvant (n = 96), and 57 percent with MF59 adjuvant (n = 92).

Design and Characterization of a Computationally Optimized Broadly Reactive Hemagglutinin Vaccine for H1N1 Influenza Viruses.

Using a crystal structure of a complex protein compound of botulinum neurotoxin, Rongsheng Jin, associate professor of physiology & biophysics at UC Irvine, and collaborators found that these compounds — called clostridial hemagglutinin (HA)-- bind with epithelial cell proteins in the intestines of patients, which initiates a process that disrupts the close intercellular seals so that the complex toxin molecules can slip through the epithelial barrier.

Another mutation, in the T200A position, allows hemagglutinin to bind more strongly to glycan receptors, making the virus more infectious.

The method described by Kawaoka and his colleagues is conceptually different in that it mimics the mutations that occur in nature and accelerates their accumulation in the critical hemagglutinin protein.

Three mutations in or near hemagglutinin's binding site (yellow) and one on its stalk increased transmissibility.

A mere four mutations in the avian hemagglutinin — the H5 — allowed this hybrid virus to bind more strongly to mammalian cells and copy itself at high enough levels to readily transmit via respiratory droplets.

Instead of glomming onto hemagglutinin's variable head, the antibody nestles into three pockets on the tail, or stem, of the virus.

But Tompkins warns that repeated vaccinations with distinct hemagglutinins would probably be needed to protect birds from the many strains of avian influenza virus.

The researchers trawled their gigantic library of more than 27 billion human antibodies to determine which molecules latch onto H5, the version of hemagglutinin carried by the avian flu virus.

Because hemagglutinin also happens to be the part of the flu vaccine that induces an immune response in people (it's the H in a virus name like H5N1), each mutation renders the vaccine less effective.

Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor - binding and pH - dependent fusion activities.

The expression vector contained the cDNAs coding for a potential fusion protein containing the GFP (EGFP), the 2A esterase of foot - and - mouth disease virus (FMDV), and HOXB4 with an additional N - terminal hemagglutinin (HA) epitope tag (eGFP2AHOXB4).

White kidney beans start off with about 1 / 3rd less hemagglutinin than red ones.

«There's no doubt we've got to focus on hemagglutinin» for developing pandemic flu vaccines, Webby says.

A glycoprotein on the virus's surface called hemagglutinin, which has 17 identified types (H1 - H17), determines how the virus sticks to and enters the host cell.

Currently, seasonal flu vaccines are designed to induce high levels of protective antibodies against hemagglutinin (HA), a protein found on the surface of the influenza virus that enables the virus to enter a human cell and initiate infection.

Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets.