Sentences with word «immunosuppressive»

The drug, described in the June Nature Medicine, also lacks the side effects of immunosuppressive drugs, such as heightened vulnerability to infection.

When T cell function declines, such as with increasing age or during use of immunosuppressive drugs, viral clearance is delayed.

Even with immunosuppressive therapy, 10 to 15 percent of kidney recipients experience rejection during the first year after transplantation.

In other cases, the patient may require a combination of immunosuppressive medications to get the condition under control.

Luznik and colleagues have sought the right balance by giving high doses of cyclophosphamide, a chemotherapy drug with immunosuppressive effects, shortly after transplantation.

«Furthermore, the recipient animals only needed treatment with immunosuppressive drugs for five days after transplantation, rather than the ongoing immunosuppression that would be needed for unmatched organs.»

Do not use with other immunosuppressive agents.

Conventionally, most transplant patients get six months of immunosuppressive treatment for that purpose.

The main predisposing risk factors for fungal infection include alterations in immunity associated with broad - spectrum antibiotic therapy, poor and sugary diet, nutrient deficiencies, heightened toxic exposure, stress, underlying malignancy, HIV infection, organ transplantation, chemotherapy and other immunosuppressive drug therapy.

Some cats do need steroids (temporary or long - term) but we need to focus more heavily on feeding these patients an appropriate diet rather than simply relying on immunosuppressive medications.

«We have shown that with the right combination of signals, the endogenous immune system can routinely overcome large immunosuppressive tumors, which was an unanswered question,» says Darrell Irvine, a professor of biological engineering and of materials science and engineering, and a member of MIT's Koch Institute for Integrative Cancer Research.

Despite these caveats, certain MSC secreted products such as HGF are likely to contribute to creating a local immunosuppressive environment.

Regulatory T cells (Tregs) are a unique subset of CD4 + T cells with immunosuppressive properties.

Stress, crowding, poor sanitation, parasitism, and concurrent diseases, particularly immunosuppressive diseases such as feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV), may also increase the impact of FIPV on cats in these environments.

By receiving transplants of bone marrow cells along with the new kidney, four of five transplant patients with end - stage renal disease were able to stop taking immunosuppressive drugs within about one year after surgery.

Moreover, mTORC1 inhibitors such as rapamycin are currently used as immunosuppressive agents and anti-cancer drugs.

Therapy centers on immunosuppressive doses of steroids and sometimes the use of additional chemotherapeutic agents.

Hi Caveman Doctor, I am interested in the potential effects of fasting on chronic autoimmune conditions where the immune system is already being depleted by immunosuppressive medications including rituximab / mabthera also used in the treatment of lymphomas.

It is approved by the U.S. Food and Drug Administration (FDA) for treating certain types of leukemia and is helpful in other conditions that require immunosuppressive therapy.

Researchers found the gene therapy approach had stronger results when used in combination with either depletion of immunosuppressive cells from the tumor mass or with immune checkpoint blockade.

You still need powerful immunosuppressive drugs that cause cancer.

While immunosuppressive states are not common in dogs, reports of their occurrence are on the rise.

Similarly, mice without immunosuppressive lymphocytes hardly had any tumors, even at 11 months, presumably since their absence left the cytotoxic T cells alone to do their tumor - fighting job.

Yet it turns out miraculously to have potent immunosuppressive properties that allow doctors to successfully perform a liver transplant in a young girl.

Further investigation into what triggers immunosuppressive phenotypes in early - stage HER2 - positive breast cancers with residual disease is warranted.»

Every kitten and cat should be tested for Feline Leukemia (this is usually tested in combination with Feline Immunosuppressive Virus / FIV).

Long term care includes immunosuppressive therapy for several months post-crisis.

Current immunosuppressive regimens used in clinical transplantiation showed limited efficacy and important side effects.

«Our results imply that tolerant patients who experience rejection could be treated with short - term immunosuppressive medications to protect the transplant, and then weaned off once tolerance returns.»

Since tumors use immunosuppressive mechanisms of the host to protect themselves against the immune response, we also hope to find ways to improve cancer therapy.

APOQUEL has not been evaluated in combination with systemic immunosuppressive agents such as glucocorticoids or cyclosporine.

Deaths are rare, mainly occurring in people who also suffer from immunosuppressive diseases.

They also highlight the potential broader risk of treating HIV - positive individuals — whose immune systems remain compromised even on antiretroviral therapy — with HDAC inhibitors that have shown immunosuppressive activity in several studies, including this one.

Among the mechanisms identified as underlying the combination treatment's effects was changing a population of immunosuppressive T cells into a type that could enhance an antitumor immune response.

Strong immunosuppressive medications have worked to maintain day vision in a few of our patients, but these drugs have side effects so bloodwork must be monitored over time.

Chemo is different and more immunosuppressive.

Other immunosuppressive medicines include azathioprine, chlorambucil and budesonide.

Just as in dogs, both systemic and topical immunosuppressive therapies can trigger demodicosis in cats, especially in cases involving D. cati.

In addition, we recommend testing all cats and kittens for FELV (feline leukemia virus), and FIV (feline immunosuppressive virus).

The JDF Center for Islet Cell Transplantation will fund 32 researchers to focus on four main goals: Reversing the overactive immune response that kills islet cells; finding new sources for islet cell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantation.

Although the former may require targeting additional antigens, the authors said, the latter may be overcome with existing drugs that target immunosuppressive molecules, such as checkpoint inhibitors used to successfully treat other cancers.

New immunosuppressive drugs also have made it possible to transplant bone marrow or peripheral stem cells from a donor less closely matched to the host.

They inhibit the abilities of tumor - infiltrating white blood cells and increase the abilities of immunosuppressive regulatory T cells.

She has been off immunosuppressive drugs for seven months.

Tumors can suppress CD4 + T cell activity and CTL tumor lysis directly through secretion of immunosuppressive factors including TGF - β1 but also PGE - 2, and IL - 10.