Sentences with phrase «in tumors»

The researchers identified a genetic mutation in the tumor cells that plays a role in both the growth and the death of a cell.

In fact, specific mutations in tumor cells were associated with the presence of specific types of bacteria in the microbiome.

These signaling molecules may also play a role in tumor development in other organs, and are being evaluated in melanoma and other tumor types.

This method also offers new ways to seek personalized treatments for cancer patients depending on the types of mutations found in their tumors, the researchers say.

The dog is still happy 9 months later with very little change in the tumor size.

The data allowed the researchers to generate personalized genome - scale metabolic models for cancer patients to identify key genes involved in tumor growth.

In the study scientists will be looking for mutations in all the genes in the tumors.

This would be expected to promote tumor progression and could therefore explain the increase in tumors in these mice.

Two tumors (4 %) had a partial response, defined as reduction in tumor volume of more than 30 percent.

Understanding this in stem cells could further understanding on how these proteins are involved in tumor growth.

This lengthy period of time, compared to a mouse's lifetime, indicates that additional factors play a role in tumor development.

They are studying patient biopsy samples and mouse models to understand why there is variation within a tumor and why that variation is not present in all tumors.

Treatment of breast cancer differs by patient due to differences in tumors.

The fat stored in your body can produce estrogen (which can also lead to breast cancer) or proteins that cause inflammation and insulin resistance, resulting in tumor cell growth.

«We saw the formation of new blood vessels in tumors reduced by 70 percent,» she says.

Currently, molecular targets for cancer therapy must either be exclusively expressed by tumor cells or expressed at significantly higher levels in tumors than in normal tissues.

This led to a significant reduction in tumor size.

He was able to isolate viral DNA in tumors.

The particles are stable enough to last in the bloodstream for up to 20 hours, long enough to accumulate in a tumor in mice.

Think about it, these single gene changes are usually what results in tumor formation, right?

The other 88 mutations occurred in some tumor cells but not others.

These genomic changes led to high mutation rates in both tumor types.

«But it appears the key may be to combine it with other drugs to shut off multiple key pathways in those tumors,» she adds.

However, it is the nature of all molecular targeting therapies that they can only be effective if the target is sufficiently expressed in the tumors.

In 89 % of patients, at least one genetic change detected in the tumor was also detected in the blood.

Many cancers are still difficult to treat and development of drugs exploiting new pathways and mechanisms involved in tumor initiation and malignant growth is of high priority [1].

Although therapies tailored based on genetic alterations in these tumors have been developed, their benefit is usually short - lived.

After surgical removal, the metabolic processes in a tumor change in a very short period of time, so that valuable information about the tumor tissue is lost during a conventional sampling procedure.

These mutations also were enriched in the tumors, supporting a likely role in cancer.

This is an amazing device that is used in tumor surgery in a select number of hospitals around the world, and even fewer veterinary hospitals!

One found that people who had more T cells in their tumors before the treatment began tended to fare better.

«If you show it works in tumor studies, I have no trouble with it being the guideline for tumor studies,» he says.

This drug is then free to bind to receptors in the tumor cell's membrane, triggering programmed cell death.

Yet cancer metabolism, like everything else that happens in tumors, is very complex, and a therapy that's effective against one metabolic process may not work against another.

Researchers don't know what fetal cells are doing in tumors, but they aren't prepared to give the cells a clean bill of health.

There are a variety of mechanisms of immune resistance that operate in the tumor.

Less suppression of the immune response and less blood vessel formation in the tumor leads to less tumor growth.

Another potential use of this information is that in certain groups, there was a similarity in the type of genes and pathways that were disrupted in the tumors.

Identifying this process could inform the development of better ways to control cholesterol accumulation in tumors, potentially leading to improved survival for prostate cancer patients.

As expected, tier 1 mutations comprised the smallest category and tier 3 the largest in all tumors.

For example, because individual cells in the tumor probably carry unique mutations, they would be virtually impossible to observe with standard sequencing methods.

The researchers achieved this tour de force by studying the mitochondria in tumor cells.

The goal is to make metabolic processes in tumors visible in their entirety and thus to better understand them.

The expression of all human genes was analyzed in these tumors and correlated with different clinical parameters.

Researchers also identified a group of patients with a small number of mutations in the tumor whose disease progression was very slow.

This in turn allows accumulation of this fat in tumor cells.

In this clinical trial, adult patients are assigned to targeted treatments based on the genetic abnormalities in their tumors, regardless of the type of cancer they have.

Or knowing any of the hundreds of genetic mutations that appear in tumor cells across the land?

Recent improvements in tumor detection and precise image - guided radiation therapy, however, have made simultaneous treatment of multiple tumor sites with radiation feasible.