Sentences with phrase «kinase activity»

The ABL tyrosine kinase activity of BCR - Abl is elevated relative to wild - type ABL.

To cite a few instances, polymerase chain reaction (PCR), a molecular method developed over three decades ago, has been widely applied in disease diagnosis, disease mechanism deciphering, and prognosis prediction; the elucidation of tyrosine kinase activity in cancer cells has led to the development of novel drugs for cancer treatment; and the identification of proteins and genetic molecules by molecular methods as biomarkers for disease diagnosis and prognosis has been drawing great interest.

ATM and ATR protein kinase activity confers cellular resistance to the cytotoxic effects of the anthelminthic drug niclosamide.

Burgener et al. «Fluoride Increases Tyrosine Kinase Activity in Osteoblast - Like Cells: Regulatory Role for the Stimulation of Cell Proliferation and Pi Transport Across the Plasma Membrane», Journal of Bone and Mineral Research, 10 (1): 164 - 171, 1995.

Similarly, inhibiting ABL kinase activity with the allosteric inhibitor GNF5 decreased TAZ protein abundance (fig.

When compared with inhibition with ponatinib (a known RIPK2 inhibitor and chemical template for selecting our RIPK2 small molecule), our RIPK2 inhibitor performed equally to inhibit RIPK2 kinase activity in an in vitro kinase assay in two different cell lines (Fig. 4D).

It significantly inhibits serum creatine kinase activity and incidences of ventricular tachycardia.

That increased kinase activity presents a potential treatment opportunity, they said.

«As a result, researchers have used the presence of IBs and heightened kinase activity as a proxy for measuring LRRK2's harmful effects, rather than measuring LRRK2 levels directly,» explained Dr. Finkbeiner, who is the associate director of neurological research at Gladstone as well as a professor at the University of California, San Francisco, with which Gladstone is affiliated.

Fructose selectively modulates c - jun N - Terminal kinase activity and insulin signaling in rat primary hepatocytes..

«As a result, researchers have used the presence of IBs and heightened kinase activity as a proxy for measuring LRRK2's harmful effects, rather than measuring LRRK2 levels directly,» explained Dr. Finkbeiner.

(A) Kinase activity for c - ABL was tested in the presence of inhibitors 1 and 2.

The mechanism by which rapamycin inhibits mTOR - raptor complex kinase activity is not completely understood.

Keeping R and C separate can help sustaining kinase activity critical for relaxing smooth muscle.

The current thinking is that Pten's phosphatase activity counteracts PI3 kinase activity.

It has been observed that mutated BRAF not only upregulates its own kinase activity, but also that of MEK and ERK, which in turn promotes cell proliferation [34].

Quizartinib inhibits FLT3 kinase activity and induced about a 50 % composite response rate among patients with FLT3 - ITD mutations in phase I and II studies, said lead author Mahesh Swaminathan, MD of the University of Texas MD Anderson Cancer Center in Houston.

Williams T. *, Courchet J. *, Viollet B. Brenman J.E. and Polleux F. (2011) AMPK kinase activity is not required for neuronal development but regulates axogenesis during metabolic stress.

The mutation is acquired, is present in a variable proportion of granulocytes, alters a highly conserved valine present in the negative regulatory JH2 domain, and is predicted to dysregulate kinase activity.

Kapoor P, Bao Y, Xiao J, Luo J, Shen J, Persinger J, Peng G, Ranish J, Bartholomew B, Shen X. (2015) Regulation of Mec1 kinase activity by the SWI / SNF chromatin remodeling complex.

Kapoor P, Bao Y, Xiao J, Espejo A, Yang L, Bedford MT, Peng G, Shen X. (2015) Phosphorylation - Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex.

Pim - 3, a Proto - Oncogene with Serine / Threonine Kinase Activity, Is Aberrantly Expressed in Human Pancreatic Cancer and Phosphorylates Bad to Block Bad - Mediated Apoptosis in Human Pancreatic Cancer Cell Lines

ERK1 / 2 activity was inhibited using U0126, PI3K - AKT kinase activity was inhibited using LY294002 and JNK activity was inhibited using SP600125 (all were from Calbiochem, USA).

He received his MSc and his PhD in Molecular Pharmacology and Oncology at the Institute for Higher Studies of the University of Ferrara exploring the role of LRRK2 kinase activity in mouse model of model of familial Parkinson's disease and performing studies focused on the phenomena underlying neurodegeneration.

We found that canonical signaling by the EphB4 receptor is low in breast cancer cells and that ephrin - induced stimulation of EphB4 kinase activity inhibits breast cancer cell malignancy in culture and tumor growth in vivo (Figure 1A) through inhibition of the CRK proto - oncogene.

Several hits were obtained, and after structural optimization, a RIPK2 inhibitor was obtained to inhibit RIPK2 kinase activity at 3 nM (He et al., 2017).

For example, our past work showed that two conserved tyrosine phosphorylation sites in the juxtamembrane segment of the Eph receptors not only mediate association with binding partners but also regulate receptor kinase activity.

Tyrosine phosphorylation sites (yellow circles) promote Eph kinase activity and also provide binding sites for signaling proteins containing SH2 domains.

Activation of Stat3 in v - Src - transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity

Sequence comparison of the polymerase gene of paramyxoviruses has revealed six highly conserved domains (I to VI), which are predicted to be essential for the key functions of RNA binding, RNA replication, and protein kinase activity [17], [18].

Serum thymidine kinase activity in canine splenic hemangiosarcoma.

Serum creatine kinase activity was elevated in all affected dogs.

So we looked to see whether middle T also had an associated protein kinase activity, and we were delighted to find that it did.»

Thus, the altered gene expression profiles correlate with decreased ABL kinase activity in breast cancer cells.

Analysis of RIPK2 kinase activity.

Fructose selectively modulates c - jun N - terminal kinase activity and insulin signaling in rat primary hepatocytes.