Sentences with phrase «of gene variants»

They found that people who carried at least one copy of the gene variant lived, on average, 10 years longer, dying at the median age of 85.

This is the prospect raised by the discovery of gene variants that seem to predict whether an individual will produce enough antibodies in response to a vaccine to protect them against disease.

The frequency of the gene variants varied from 6 to 14 % of the population of men with prostate cancer.

There are a number of gene variants that may hold the key to a healthy old age life.

Of these, 43 people carried at least one copy of the gene variant.

The researchers are currently planning a study with a larger patient sample and a broader mapping of the genome, to provide a more definitive picture of the gene variants associated with delayed fracture healing.

«Thus, the combination of gene variants contributed from the two interbreeding species in combination with natural selection led to the evolution of a beak morphology that was competitive and unique.»

The new study focused on 40 cognitively healthy older adults between the ages of 65 and 75 who are carriers of a gene variant (APOE e4) that is known to contribute to the risk of developing late - onset Alzheimer's disease.

November 10, 2005 Major discovery with rapid applicability to the development of new medicine Reykjavik, ICELAND, November 10, 2005 — A paper by a deCODE - led team of scientists published today presents the discovery of a gene variant conferring increased risk of...

The identification of gene variants contributing to stroke is expected to help elucidate the mechanisms causing this affliction, and will ultimately facilitate both better prediction and early intervention or prevention.

A population - based study by a team of deCODE scientists and colleagues at Iceland's National University Hospital published today provides a detailed look at the impact of a gene variant on risk of breast cancer.

June 20, 2006 A population - based study by a team of deCODE scientists and colleagues at Iceland's National University Hospital published today provides a detailed look at the impact of a gene variant on risk of breast cancer.

The trial was designed to examine the effect of various doses of DG031 on certain biomarkers linked to arterial inflammation and risk of heart attack in patients with a history of heart attack and one or more of the gene variants deCODE has linked to increased risk of the disease.

If the new combination of gene variants make the offspring better suited for growth in its current environment, that bacterium will rapidly divide asexually, outcompete its parental (or sibling) strains and become established as an emerging strain or species in its own right.

This allowed a suite of gene variants to evolve together, creating males that look like females but have larger testes than ordinary males.

The increased risk closely correlates with the frequency of a gene variant previously associated with that adverse reaction, supporting recommendations to screen for that variant in patients from those populations.

Scientists also know dozens of gene variants that increase people's risk of lupus.

The discovery of gene variants illuminates the biological mechanisms for the disorder, which affects 4 percent of people age 40 and older.

«We don't know if studying the fish will directly help us,» said Rohner, «but evolution has tried a lot of gene variants over millions of years and I think that's smarter than anything we can come up with, even with machine learning.

«As we identify other vulnerability genes like this,» says Levitt, who hopes to engineer a mouse model of this gene variant for study, «we may be able to develop effective interventions for children.»

Researchers have identified a new host of gene variants that could make people vulnerable to sporadic motor neuron disease, according to a report published in the journal, Scientific Reports.

DNA analysis of nine prehistoric skeletons finds no sign of a gene variant conferring the ability to digest milk

«Many of the gene variants that cause light skin in Europe have origins in Africa,» Tishkoff says.

By sequencing a remarkably complete genome from a 50,000 - year - old bone fragment of a female Neandertal found in Vindija Cave in Croatia, researchers report a new trove of gene variants that living people outside of Africa obtained from Neandertals.

Closer examination of this gene variant suggested it may regulate the expression of a neighboring gene, SLC39A8, which is known to help protect the airways and lungs from inflammation and cellular damage.

In the most extreme cases, about a quarter of the genomes of Przewalski's horses consisted of gene variants inherited from domesticated horses.

«We found that while hybridisation has not compromised the genetic distinctiveness of wolf populations, a large number of wild wolves in Eurasia carry a small proportion of gene variants derived from dogs, leading to the ambiguity of how we define genetically «pure wolves».

A quantitative model of development would have the potential to predict, for example, the consequences of having copies of gene variants which may be associated with disease, and would help us identify new genes that are critical for development.»

the evolution of domesticated animals has been underway for so long that we can now see the evolution of gene variants, that is, genes in which several successive mutations gradually changed the function of the gene.

An array of gene variants provides «breakthrough benefits» in tomato yield for breeders; other crops next...

A deeper meta - analysis looking at a longer list of gene variants is currently underway, and individual groups within the consortium are using the pooled dataset to answer additional questions.

However, the discovery of this gene variant does bolster the idea that glutamate activity is important in the development of this disease, she explains.

They compared a genetic marker in a population in India (most of which ate meat) to a U.S. population and found higher rates of a gene variant that facilitates the elongation of omega 6 fatty acids.

The widely used strategy of allele association investigates correlations of gene variants with phenotypes, i.e., it probes if individuals with a trait of interest carry a specific gene variant more frequently than individuals in a control group (case - control studies).

«How a drug is going to work on a carrier of the gene variant could be worse or it could be better, but it's likely going to be different,» Connor said.

«It might be difficult to imagine why the large number of gene variants that together give rise to traits like [autism spectrum disorder] are retained in human populations,» co-author and genetics and neuroscience professor Joel Gelernter said in a statement from Yale University.

The identification of gene variants that delay fracture healing could lead to screening tests for patients with broken bones.

The payoff is that sexual reproduction allows the mixing of parental genomes to generate potentially beneficial new combinations of gene variants that had not previously coexisted on the same strand of DNA, or to separate beneficial mutations from detrimental ones.

The researchers found that people who have more copies of the gene variants (by inheriting a copy of each advantageous variant from both parents), had the least amount of oxygen in their blood and used it more efficiently than people without either variant, or only one copy from one parent.

Initiated in February 1998, and covering up to 12 common diseases, the five - year collaboration is focusing on the discovery of gene variants that predispose and / or contribute to the development of these diseases, with a major emphasis on six of them.

Two of those gene variants are most similar to the Neanderthal genome, whereas the third is most similar to the Denisovan genome, Kelso's group reports.

According to a study published in the Proceedings of the Royal Society, there is evidence that some of the gene variants associated with schizophrenia — especially a mutation in a gene called disrupted - in - schizophrenia1 (DISC1)-- have been selected for by evolution.

Women who carry at least one copy of a gene variant, or allele, that codes for high oxygen saturation had 125 percent more surviving children than those who carry two copies of a low - saturation allele.

We screened a total of 394 Amish research subjects for the KCNH7 mutation; 84 of these individuals carried at least one copy of the gene variant, and the lifetime incidence of bipolar spectrum disorders among them was 49 percent (41 people were affected with the disease).

To be at risk for developing CKD, an individual must have inherited two of these gene variants, one from each parent.

Seven of these gene variants, as expected, appeared to increase risk for both diseases.