Sentences with word «phosphatidylinositol»

Here's the scientific description: «In this process, the capsaicin receptor (TRPV1) is sensitized by phosphatidylinositol -4,5-bisphosphate (PIP2) hydrolysis following phospholipase C activation.»

This, in turn, is actually a lipid kinase and it phosphorylates lipids on the plasma membrane, making a new or synthesizing a new phosphate or a lipid phosphatidylinositol lipid called PIP - 3.

PTEN can also reduce the levels of another similar molecule known as phosphatidylinositol -3,4-bisphosphate (PI (3,4) P2).

Co-author, «Treatment of A431 Cells with Epidermal Growth Factor (EGF) Induces Desensitization of EGF - Stimulated Phosphatidylinositol Turnover,» The Journal of Biological Chemistry, 1989

Previously, nucleophosmin - ALK has been shown to activate phosphatidylinositol 3 - kinase (PI3K) and its downstream effector, the serine / threonine kinase AKT.

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate - 1 (IRS - 1)- associated phosphatidylinositol 3 - kinase activity in muscle.

Beclin 1 forms two distinct phosphatidylinositol 3 - kinase complexes with mammalian Atg14 and UVRAG.

By regulating the levels of the chemical phosphatidylinositol -3,4,5-trisphosphate (PI (3,4,5) P3), PTEN helps to limit cell growth and so prevents cancer.

We regenerated cells stably expressing ectopic wild - type and mutant phosphatidylinositol -3,4,5-trisphosphate-dependent Rac exchange factor 2 (PREX2) using the same immortalized human NRASG12D melanocytes as the original study.

PREX2: phosphatidylinositol -3,4,5-triphosphate-dependent RAC exchange factor 2.

Lars Demmel (Walch - Solimena, MPG)-- «Unraveling phosphatidylinositol 4 - kinase function in the yeast Golgi - endosomal system» (2005)

Metlakunta AS, Sahu M, Sahu A. Hypothalamic phosphatidylinositol 3 - kinase pathway of leptin signaling is impaired during the development of diet - induced obesity in FVB / N mice.

This leads to production of this lipid called PIP3 (phosphatidylinositol trisphosphate), and this, in turn, has been shown to lead to a remodeling of actin, F - actin turning into G - actin.

In what concerns intra-membrane constituents, the focus of interest has been on phosphatidylinositol lipids and their capacity to orchestrate endocytic events on the cytosolic leaflet of the membrane.

Phosphatidylinositol -3-kinase (PI3K) inhibitors (LY294002 (10 μM) and wortmannin (10 μM)-RRB- and an AKT inhibitor (deguelin (0.1 or 0.2 μM)-RRB- were added to the 293, 293T, HepG2, and Hepa - 1c1c7 cells that had been treated with ActD.

Researchers at the Kyung Hee University in Korea discovered how: like insulin, EGCG [structural formula below] activates the enzyme phosphatidylinositol (PI) 3 - kinase.

The study showed that cinnamon reduced insulin resistance by increasing phosphatidylinositol 3 - kinase activity in the insulin signaling pathway.

Roles of phosphatidylinositol 3 - kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine - choline - deficient medium.

Inositol is a carbohydrate and the body uses it to make structural lipids such as phosphatidylinositol.

RESULTS: Short - term treatment of 3T3 - L1 adipocytes with R (+) alpha - lipoic acid rapidly stimulated glucose uptake in a wortmannin - sensitive manner, induced a redistribution of GLUT1 and GLUT4 to the plasma membrane, caused tyrosine phosphorylation of insulin receptor substrate - 1 and of the insulin receptor, increased the antiphosphotyrosine - associated and insulin receptor substrate - 1 associated phosphatidylinositol 3 - kinase activity and stimulated Akt activity.

Antigen - specific enhancement of natural human IgG antibodies to phosphatidylcholine, phosphatidylglycerol, phosphatidylinositol -4-phosphate, cholesterol, and lipid A by a liposomal vaccine Containing lipid A.Vaccine.

Western blot analyses with phospho - specific antibodies suggested that stretching induces phosphorylation of ERK of the MAP kinase pathway, but did not induce phosphorylation of phosphatidylinositol 3 - kinase.

Interactome mapping of the phosphatidylinositol 3 - kinase - mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor - 1 as a new glycogen synthase kinase - 3 interactor

Molecular genesis of cutaneous melanoma pathways; rous avian sarcoma homologue (Ras); v - raf murine sarcoma viral oncogene homologue B1 (BRAF); mitogen - activated protein kinase (MEK); extracellular signal - regulated kinase (ERK); microphthalmia transcription factor (Mitf); phosphatidylinositol - 3 kinase (PI3K); murine v - akt oncogene homologue (Akt).

Research in the Emerling Lab is focused on phosphoinositide signaling, in particular the role of the phosphatidylinositol -5-phosphate 4 - kinases (PI5P4Ks) in cancer metabolism.

Burke specifically studies the phosphoinositide 3 - kinase and phosphatidylinositol 4 - kinase families.