Sentences with word «proliferative»

In highly proliferative lesions with increased Ki67, estrogen receptor was negative, but human epidermal growth factor receptor 2 was usually positive with a distribution that was similar to that reported for human intraepithelial lesions (7).

Phase 2 — Proliferative Phase: In this phase, granulation, contraction, and epithelialization of the injured tissues occurs.

The strict limit in proliferative potential of normal human somatic cells - a process known as replicative senescence - is highly relevant to the immune system, because clonal expansion is fundamental to adaptive immunity.

These roles of EBI2 in DCs are necessary for supporting normal CD4 T cell and B cell proliferative responses, and early plasma cell and germinal center responses to particulate blood - borne antigens.

It also found that prolonged delays in initiation may limit the therapeutic effect and that, although uncommon, development of proliferative diabetic retinopathy still occurs in some eyes undergoing anti-VEGF therapy.

These findings are consistent with an estrogenic hormonal proliferative effect on breast tissue (6 — 10) that is reflected in the amount of dense tissue and breast density (11).

First, the loss of mitotic competence of stem cells denies proliferative tissues of the capacity for renewal.

Parsa R, Yang A, McKeon F, Green H. Association of p63 with proliferative potential in normal and neoplastic human keratinocytes.

This period is characterized by rapid ductal growth and active proliferative activity of the mammary epithelium of Lob 1.

In the new study, Lucentis was compared to scatter laser therapy (or panretinal photocoagulation), which has been the standard treatment for proliferative diabetic retinopathy since the 1970s.

Surgical and medical treatment of an Arabian filly with proliferative enteropathy.

Although the work is at the first stage of development, it excites team leader David L. Spector, Ph.D., because in mouse models of human metastatic breast cancer it has produced «differentiation of an aggressive primary tumor, redirecting it from a highly proliferative state, and reducing its metastatic activity by 70 percent.»

Most TCCs vary between intermediate to high grade papillary proliferative lesions.

They're basically «souped up» and have much more proliferative capacity than those that that have been elicited with other therapeutic vaccines.

In this research, the group looked at two variants of miR - 21, a microRNA «oncomiR» known to target tumor suppressor genes and which is highly expressed in a number of cancers as well as other proliferative diseases such as psoriasis.

Their subsequent work (3) in clonal cultures revealed three distinct types of clones with profoundly different proliferative capacity.

Severe weight loss is displayed in this 5 - month - old American Quarter Horse colt with equine proliferative enteropathy.

An advanced stage, called proliferative diabetic retinopathy, occurs when abnormal blood vessels grow near the retina, the light - sensitive tissue at the back of the eye.

A striking aspect of organ regeneration is how injury transforms differentiated, functional tissue into proliferative, regenerative cells that coordinate tissue replacement.

But if, as this study suggests, the way that cells become proliferative again is similar across many different organs, we can imagine therapies that interfere with cancer initiation in a more global way, regardless of where that cancer may appear in the body,» he explains.

Earlier this month, a network of researchers supported by the National Eye Institute (NEI) found that the drug Lucentis (ranibizumab) can be highly effective for treating proliferative diabetic retinopathy, an eye disease that can occur as a complication of diabetes.

Embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) possess unlimited proliferative capacity and represent the infinite supply of pluripotent cells.

CSM - affected dogs had significantly greater sclerosis and degree of proliferative changes of articular process joints than the normal dogs.

BCL9 promotes tumor progression by conferring enhanced proliferative, metastatic, and angiogenic properties to cancer cells.

Geoff Wahl's work on the link between development and cancer has demonstrated that the invasive and proliferative processes of mammogenesis resemble phases of cancer progression.

It involves the injection of a natural proliferative fluid to the intra-articular joint space and...

Equine proliferative enteropathy (EPE) is a transmissible intestinal disease caused by the bacteria Lawsonia intracellularis (LI), commonly known as «Lawsonia disease.»

Also called proliferative ileitis and regional enteritis, wet tail is a highly contagious disease and most common in recently weaned hamsters.

Some bacteria, such as Helicobacter musteli (a spiral - type of bacteria), Salmonella, Campylobacter (the cause of proliferative colitis in ferrets) and clostridia, can cause diarrhea in ferrets.

Abstract: Fifty - eight dogs with lytic or proliferative bone lesions were treated with a radiation protocol of two 8 - Gy fractions over 2 consecutive days.

Meaning, 2 - OH estrogen won't contribute much to the harmful, proliferative [or harmful tissue - growing (as in cancer growth) effects] of estrogen.

These high - risk cancers exhibit increased proliferative abilities and a facility to «hide» from the body's immune system.

Interestingly, this state appears to differ from that of quiescent fibroblasts in the uninjured heart, as it is resistant to proliferative stimuli.

By 7 to 10 days, myofibroblasts lost proliferative ability and smooth muscle α - actin expression as the collagen - containing extracellular matrix and scar fully matured.

Cell cycle protein expression and proliferative status in human corneal cells.

The authors conclude that their six hallmarks — sustained proliferative signaling, evading growth suppression, resisting cell death, replicative immortality, induction of angiogenesis, and invasion / metastasis — continue to provide a useful conceptual framework for understanding the biology of cancer.

A microRNA network regulates proliferative timing and extracellular matrix synthesis during cellular quiescence in fibroblasts.

During postnatal growth of the skin and homeostatic hair cycling, different proliferative compartments contribute to tissue expansion and establishment of a functional epidermis.

A subject with rapidly proliferative disease and unable to wait for the central lab results can be enrolled based on a local test performed after completion of the last interventional treatment.