Sentences with word «reductase»
"Reductase" refers to an enzyme that helps to reduce or break down certain substances into simpler forms. It plays a crucial role in many biological processes by catalyzing chemical reactions that involve reducing agents. Full definition
«Working closely with Professor Srivastava and other UTMB faculty, the next step is to prove the safety and efficacy of aldose reductase inhibitors for these conditions and develop them to improve the health of millions of people,» said Jason Abair, associate vice president of the center.
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Inhibitory Effects of Zingiber officinale Roscoe Derived Components on Aldose Reductase Activity in Vitro and in Vivo.
Certain foods are known for their decreasing effects on the activity of the 5 - alpha reductase enzyme.
Interaction effects were significant for 2 maternal genes, which included a well researched variant on the methylenetetrahydrofolate reductase gene linked to increased levels of the amino acid homocysteine and less efficient folate metabolism.
It all started when scientists were nobly investigating prostate health, and discovered that nettle root was able to inhibit 5 - alpha reductase activity.
«This is the first time that geranylgeraniol was found to suppress HMG CoA reductase in prostate cancer cells,» said Dr. Russell DeBose - Boyd, co-author and professor in the Department of Molecular Genetics and Howard Hughes Medical Institute at UTSW.
And it is just these differences, and the fact that certain bacteria lack the glutaredoxin system, that mean that drugs that affect thioredoxin reductase can be used as antibiotics.
Furthermore, green tea activates enzymes such as quinone reductase and glutathione, both of which have detoxification properties.
This is partially due to an increased activity of an enzyme known as 5 - alpha reductase as men age.
A study published in Cancer Research in March 2005 showed that ECGC inhibits the enzyme dihydrofolate reductase (DHFR) which cancer cells need in order to grow.
High - fat diet induced neuropathy of pre-diabetes and obesity: effects of «healthy» diet and aldose reductase inhibition.
«What this means is that wherever we find arsenite, we can expect to find microbes with arsenate reductase genes and vice versa.»
Reporting the first association between genetic variants in the human steroid 5a - reductase type II (encoded by the SRD5A2 gene) and prostate cancer in 1999.
Comparing spearmint to other popular anti-androgens for acne, green tea and saw palmetto both target DHT specifically, inhibiting the enzyme 5 - alpha reductase which converts testosterone to DHT via their epigallocatechin gallate and stigmasterol compounds.
Löffler, J., Trojovsky, A., Casati, B., Kroisel, P.M. & Utermann, G. Homozygosity for the W151X stop mutation in the δ7 - sterol reductase gene (DHCR7) causing a lethal form of Smith - Lemli - Opitz syndrome: retrospective molecular diagnosis.
Infants in this age range are vulnerable because they have not matured enough to produce methemoglobin reductase, an oxygen - carrying molecule.
BACKGROUND AND AIMS Nitric oxide (NO) has been demonstrated to stimulate the activity of nitrate reductase (NR) in plant roots supplied with a low level of nitrate, and to affect proteins
«Reverse engineering» the BH4 pathway reveals sepiapterin reductase as a new target for analgesic treatments.
One such disease is Smith - Lemli - Opitz syndrome (also called «SLOS,» or 7 - dehydrocholesterol reductase deficiency) which is a metabolic and congenital disorder leading to a number of problems including autism, mental retardation, lack of muscle, and many others.
One of the first enzymes is 3 - hydroxy -3-methylglutaryl-CoA reductase, also known as HMGCR, the main target of statins.
Divalent metal - dependent catalysis and cleavage specificity of CSP41, a chloroplast endoribonuclease belonging to the short chain dehydrogenase / reductase superfamily
At Scripps, Crane studied metalloenzymes and applied structural biology techniques to trying to understand the catalytic mechanisms of two types of redox enzymes, sulfite reductases and nitric oxide synthases.
It works by interfering with vitamin K epoxide reductase, an enzyme involved in the blood clotting process.
Lower total and LDL - cholesterol concentrations after the EB period might be due to a lower insulin stimulation of hydroxyl methyl glutaryl - Co-A reductase.
Saw Palmetto has been found to inhibit DHT production by reducing 5 alpha - reductase production, which may help prevent hirsutism in women with PCOS.
So an enzyme called Ferredoxin - NADP reductase, or FNR, played the role of outlet adapter.
Researchers then tested whether the samples containing high arsenite concentrations also had an abundance of the arsenate reductase genetic material.
Upstream of this nirK, is a gene encoding the NO reductase activation protein NorD.
Both types of the 5 Alpha - reductase affect the conversion of testosterone to DHT.
Enzyme blockers prevent 5 - Alpha reductase from binding with Testosterone and everything else, resulting in adverse side effects.
They further show that this diterpine downregulates HMG CoA reductase offering support to the concept that mevalonate deprivation causes cell cycle arrest at the G1 phase leading to apoptotic death of the prostate carcinoma cells.
Malaria parasites make their DNA with the help of an enzyme called ribonucleotide reductase, which contains iron.
This structure is in complex with an oxido - reductase β subunit of the kind that can regulate mammalian Kv channels in their native cell environment.
«We observed a significant correlation between reductase gene abundance and arsenite concentrations in the groundwater samples,» said Mirza.