Sentences with phrase «small number of patients»

Moreover, studies have involved a relatively small number of patients, and scientists aren't sure what complications may emerge.

Guideline authors noted, however, that the evidence for the recommendations is weak, since many of the studies had relatively small numbers of patients with similar types of epilepsy and were conducted at only one institution, so the results may not be generalizable to everyone with epilepsy.

Still, his approach will aid only the comparatively small number of patients who have tendon control.

Under current law, they can deduct 50 percent of the cost of testing drugs for rare or orphan diseases that affect only small numbers of patients.

It was based on small numbers of patients — including just seven treated with PSR.

There was a relatively small number of patients involved to make a strong conclusion.»

This method will be useful when the death risk of a novel infectious disease has to be quantified using data from small numbers of patients during the course of an outbreak, providing information on which age groups to minimize exposure in hospitals, nursing homes and daycare facilities.

Cell transplantation as a treatment for diabetes is still essentially experimental, uses cells from cadavers, requires the use of powerful immunosuppressive drugs, and has been available to only a very small number of patients.

However, research on VR applications has important limitations including small numbers of patients and lack of comparison groups.

The USIDNET registry gathers variables including clinical, laboratory and outcome data, which together provide a health survey of the relatively small number of patients affected by primary immunodeficiency disorders.

One major problem, the report says, is «overfitting»: Because the studies often look for patterns in hundreds of biomolecules using a relatively small number of patient samples, it is easy to find correlations that do not reflect the biology of patients» disease.

However, due to relatively small numbers of patients within sub-groups, the researchers caution that they did not find definitive evidence to show that effects of vitamin D supplementation differ according to baseline vitamin D status.

This work shows that TREM2 is important not just in the relatively small number of patients carrying mutations, but potentially in all of Alzheimer's.»

But with the very small number of patients we've treated to date, our data are only suggestive.»

«We look for activity of our molecules in phase 2, and on numerous occasions we generate statistically significant data with relatively small numbers of patients, which gives us reasonable confidence that the program will be successful in phase 3 with a larger group of patients.

And much of the reason its creators felt confident enough to invest all that time, money, and effort — given the small number of patients who might eventually use the medicine — can be traced to the Orphan Drug Act, a 1983 federal law that gave those who develop meds for uncommon diseases longer periods of marketing exclusivity and other financial incentives.

Scientists at Cambridge University said tests on a small number of patients who played the game over four weeks found they had improvements in memory and learning.

It's won the endorsement from the small number of patients who've tried it — but that's not the market that the Frog team needs to convince.

The negative predictive value of skin prick test / specific IgE for immediate reaction is excellent (> 95 %)[15], however a small number of these patients can have clinical reaction.

In 2014, Christiano and other CUMC researchers identified the immune cells responsible for destroying hair follicles in people with alopecia areata and tested an FDA - approved drug that led to complete hair regrowth in a small number of patients.

Plus, the researchers said they were left with inconclusive results because of the small number of patients enrolled.

The disease is generally pretty mild — on par with flu — but health workers have recently found that a small number of patients seem to go on to develop an autoimmune disorder that can cause nerve damage and paralysis called Guillain — Barré syndrome.

But we were surprised by the severity, even in this small number of patients,» says Karina Gonzalez Carta, M.D., cardiologist and research fellow at Mayo Clinic and the study's lead author.

However, because of the small number of patients and the divergent results, this study did not allow evaluation of the efficacy of MRI as a single screening modality,» the study concludes.

Again they found evidence that these immune system pathways are turned down in some patients and, that these immune genes can be turned back up in a small number of patients with breast and colorectal cancer who had been treated with epigenetic therapies.

The small number of patients and the lack of controls means that the study is not definitive, but it casts significant doubt on the effectiveness of the hormone in children who make normal levels of growth hormone, he says.

The small number of patients involved means there are few financial incentives for pharmaceutical companies to engage in research to combat them, nor any large voting bloc to encourage politicians to fund that work.

U.S. health officials are echoing this caution as a small number of patients have been released from American hospitals.

Current treatments include transplanting patients with donor HSC, which is a potential cure for SCD, but due to the serious risks of rejection, only a small number of patients have undergone this procedure and it is usually restricted to children with severe symptoms.

This would be useful for so - called «orphan drugs» — drugs needed by a small number of patients.

Additionally, viral suppression was 11 percent higher at sites with a smaller number of patients and 13 percent higher at sites with fewer patients having an undetectable viral load at the beginning of the study.

Although this is a new and interesting finding, the small number of patients in this group means that more research needs to be conducted in order to discover whether or not it sheds any light on the mechanisms involved in TTS.

The American team acknowledges that because of the small number of patients involved, it is difficult to demonstrate the benefits of myelin treatment or the effects of gender or HLA - DR2.

Schnabl cautioned that this human study is just proof - of - concept in a relatively small number of patients.

While cautioning that the quantity of evidence was less - than - optimal and that the studies were qualitatively limited by the methods used to measure sodium intake, the small number of patients with health outcomes of interest in some of the studies, and other methodological constraints, the committee concluded that:

Lee points out that, «Despite the small number of patients studied, the results clearly demonstrated that real - time feedback enhanced the results achieved through core stabilization exercise training because patients gained a better understanding of the movements as they were performing them.

Immune checkpoint blockade (ICB) has demonstrated curative potential in several types of cancer, but only for a small number of patients.

To date, no links between the small number of patients infected with the mutated virus have been found and the mutation does not appear to spread.

«One should be careful to make to strong conclusions from such a small number of patients,» Raj points out, «but it seems that in approximately half of all cases, even elderly patients may benefit from surgery and recover to an independent life.

This adds to previous hints that patients with EGFR mutations could be more prone to brain metastases than other NSCLC patients; still, that and the promising response rates should be «interpreted cautiously because of the small numbers of patients and lack of randomization,» the authors wrote.

And a small number of patients might never have to have therapy again.

«By working together, physicians will be able to ask questions about treatment approaches that would otherwise not be possible to ask in a single cooperative group or country because of the small numbers of patients.

We have identified a small number of patients who have developed this infection among the nearly 7,000 patients at Michigan Medicine who had surgery potentially using the Sorin Stöckert devices.

First of all, early clinical studies of MSCs involved small numbers of cells manufactured for a small numbers of patients.

In the coming months a small number of patients will be transplanted with fetal cells in Lund, Sweden and Cambridge, UK.

These are preliminary results, the authors caution, following a small number of patients for a short time.

Of the small number of patients who underwent a follow - up MRI, antibody responders showed similar brain volume loss during the follow - up period subsequent to the AN1792 phase 2a study compared with placebo - treated patients.

For example, pneumonitis, which a small number of patients on checkpoint inhibitor immunotherapy may experience, can cause some of the same symptoms as a bacterial respiratory infection, but should be treated with steroids instead of antibiotics.