Sentences with phrase «tumor microenvironment»
The phrase "tumor microenvironment" refers to the immediate surroundings of a tumor, including the nearby cells, blood vessels, and connective tissue. It's a term used to describe the conditions and processes that occur in this environment, which can affect the growth and behavior of the tumor. Full definition
These findings led us to investigate the roles of S1P in tumor microenvironment, and found that S1P promote not only angiogenesis, but also lymphangiogenesis and lymph node metastasis of breast cancer (Nagahashi M et al, Cancer Research 2012).
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On a brighter note, not all breast cancer patients have the kind of tumor microenvironment in which pre-op chemo can promote metastasis.
The combination of these methods enables complex tissues to be studied by single cell genomics workflows, revealing interrelationships between molecular and cellular phenotypes within tumor microenvironments.
the role of somatic stem cells in determining tumor progression and metastatic behavior, and control of the stem cell niche by tumor microenvironment
This so - called tumor microenvironment often contains cells, proteins, and other substances that deter the immune system from attacking the tumor.
«This immunosuppressive tumor microenvironment involves CD4 + and FoxP3 + cells that represent a regulatory T - cell population.
Myeloid - derived suppressor cells modulate immune responses independently of NADPH oxidase in the ovarian tumor microenvironment in mice.
However, the study also showed that the harsh tumor microenvironment remains a challenge, and that the cancer cells found a way to evade the T - cells.
Weeraratna's team used an artificial skin reconstruct model to recreate the interactions of melanoma cells with either a young or aged tumor microenvironment.
The researchers are now planning to address the impact of targeting autophagy either clinically and pharmacologically on the immune landscape of melanomas by phenotyping other immune cells in the melanoma tumor microenvironment.
Immunotherapy prolongs survival in only a subset of melanoma patients, highlighting the need to better understand the driver tumor microenvironment.
Mikala Egeblad Tumor microenvironment; intravital imaging; tumor - associated myeloid cells; breast cancer; pancreatic cancer; chemoresistance; metastasis
The PCa tumor microenvironment is comprised of a complex mixture of epithelial and stroma cell types engaged in multifaceted heterotypic interactions functioning to maintain tumor growth and immune evasion.
One limitation of our study is the use of metastatic samples from various organ sites, potentially influencing expression via differences from the organ - specific tumor microenvironment.
Examination of tumor microenvironments requires processing tissue samples into cellular suspensions while maximizing viability and preserving cell - surface markers.
The poster titled, «A novel adenosine A2A receptor antagonist optimized for high potency in adenosine - rich tumor microenvironment boosts anti-tumor immunity» will be presented by Christophe Quéva, Chief Scientific Officer at iTeos Therapeutics, on April 3, 2017 at The Walter E. Washington Convention Center Washington, D.C.
We invented a method that identified that S1P levels are high not only in breast cancer cells, but also in interstitial fluid that forms tumor microenvironment (Nagahashi M et al, Journal of Mammary Gland Biology and Neoplasia 2016).
Finally, in collaboration with physicists from the Institute Curie, we are also investigating if, in addition to cellular and biochemical tumor microenvironment, mechanical pressure imposed by stroma can stimulate invasion of cancer cells.
«3D Microfluidic Models of the Vascularized Tumor Microenvironment: Advancing Precision Medicine and Understanding Collective Migration»
Our novel data show that adenosine generated by MCs regulates tumor microenvironment by decreasing fibroblast responses to TGFβ acting through A2 adenosine receptors.
His studies revealed that the blood and lymphatic vasculature, fibroblasts, immune cells and the extracellular matrix associated with tumors are abnormal, collectively creating a hostile tumor microenvironment characterized by hypoxia, low pH and high interstitial fluid pressure.
Cancer cells use altered metabolic pathways to sustain rapid growth and to overcome enormous stress encountered in tumor microenvironment.
Dr. Jain is regarded as a trailblazer in the study of tumor microenvironment, examining in detail the notion that the relationships between tumors and their surrounding non-tumor tissue — including blood vessels — are essential determinants of disease progression, therapeutic efficacy, and patient prognosis.
Here, they observed that while estrogen receptor was absent in cancer cells, it was prevalent and in many cases increased in the so - called tumor microenvironment — the area around the tumor that helps it grow.
Research Interests: Mechanisms of immune regulation in the breast and ovarian tumor microenvironment
«We're interrogating the tumor microenvironment,» she says, «by looking at suppressive cues as well as cells and secreted proteins that protect tumors from the immune response.»
This quantitative, targeted, multiplexed approach leverages the power of next - generation sequencing and PCR technologies, and allows the researcher to obtain a molecular snapshot of the tumor microenvironment.
«This technique creates a steady, sustained release of antibodies directly into the tumor site; it is an efficient approach with enhanced retention of anti-PD-1 antibodies in the tumor microenvironment,» says Zhen Gu, an assistant professor in the biomedical engineering program and senior author of the paper.
«We have already shown that age - related changes in the tumor microenvironment are accountable for the higher metastatic potential of melanoma in older patients,» said Ashani Weeraratna, Ph.D., Ira Brind Associate Professor and program leader of the Tumor Microenvironment and Metastasis Program at Wistar and lead author of the paper.
They observed an intricate reciprocal regulation between Klotho, Wnt5A, melanoma cells, and the tumor microenvironment.
I think they may have been missing a piece of the puzzle, by not considering aging and the tumor microenvironment.»
Wistar scientists have previously shown that age - related changes in the tumor microenvironment — or the surrounding area where tumor cells crosstalk with normal and immune cells — can drive melanoma progression and therapy resistance.
They separated the cells by type to study the tumor microenvironment in cells and in mice.
Where these three cells come in contact is where tumor cells can enter blood vessels — a site called a tumor microenvironment of metastasis, or TMEM.
However, tolerance - inducing mechanisms and the presence of suppressive cell types in the tumor microenvironment can dampen the response to immunotherapy.
The research team of Dr Bassam Janji in the Laboratory of Experimental Cancer Research at LIH's Department of Oncology is specialized in the study of the tumor microenvironment in different types of solid tumors, including skin cancer.
In this rewriting of the textbooks, a tumor is not just a clump of aberrant cells; it also includes a support system, a tumor microenvironment, which encompasses a multitude of varying immune cell types and crisscrossing chemical signals, along with a network of blood vessels.
The drug Avastin inhibits production of the angiogenesis - promoting VEGF, although oncologists must contend with other molecules in the tumor microenvironment that promote blood vessel growth.
When looking for culprits, researchers have often focused their microscopes on macrophages, which occupy a meaningful spot among the white blood cells in the tumor microenvironment.
By better understanding the tumor microenvironment we can develop strategies and treatment options to neutralize its oncogenic influence and more effectively attack the tumor itself.
Discuss the importance of understanding the tumor microenvironment and how it interacts with normal cells
Basic science is also critical: Unraveling the complex interplay of cells in the tumor microenvironment, understanding how tumor mutational load influences therapeutic efficacy, and dissecting how our resident microbes shape the development and treatment of cancer will also provide important insights that will forge the way toward improving existing therapies and developing new ones.
He is regarded as a pioneer in the field of tumor microenvironment and is well known for proposing a new treatment principle — normalization of microenvironment — for treatment of malignant and nonmalignant diseases characterized by abnormal vessels that afflict more than 500 million people worldwide.
Mechanistic studies showed that IFN increases antitumor immune responses by enhancing antigen presentation to T cells by dendritic cells present in the tumor microenvironment.