Sentences with phrase «as an oncogene»

«This function for BAI1 may have implications for cancer biology, since MDM2 can function as an oncogene by degrading important tumor suppressors like p53.»

But mutated or dysfunctional Rb is associated with several major cancers and Cyclin D has long been described as an oncogene that promotes cancer because it was believed to inactivate the Rb tumor suppressor function through a process called phosphorylation, which involves phosphate molecules being added to proteins, essentially turning them on or off.

Collectively, we established SQLE as an oncogene in NAFLD - HCC and propose that repurposing SQLE inhibitors may be a promising approach for the prevention and treatment of NAFLD - HCC.

In humans, cancer develops when genes that suppress cancer, known as tumor suppressors, are lost and when mutations or genes that promote cancer, known as oncogenes, are gained or activated.

Recent active research in miRNA identified a series of this type of molecules that are involved in tumor progression in various tumors as oncogenes and tumor suppressors (8, 9).

In breast cancer, miR - 21, 155, 27, 96, 182, and 128 were identified as oncogenes, whereas miR - 125, 205, 27, 17, 206, and 145 were found to be tumor suppressor genes, and their corresponding target genes were also defined (10 — 12).

It's particularly because components of the citric acid cycle, specifically isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) have recently emerged as oncogenes that are recurrently mutated in gliomas and leukemias.

p53 is therefore well - studied as an oncogene, or a gene that when not functioning normally can contribute to a normal cell becoming cancerous.

Valproic acid reduces histone deacetylation, in effect promoting acetylation, as the oncogene does.

Now researchers are finding additional mutated metabolic enzymes that can behave as oncogenes, says Chi Dang, a medical oncologist and cancer biologist who directs the Abramson Cancer Center, and such discoveries are helping convince skeptics that alterations in metabolism are not mere «epiphenomena» or side effects.

Consequently, these tumor samples were classified as oncogene - positive.

Using a model where K - ras acts as an oncogene and initiates tumor formation, mice that were bred to not have Notch1 function showed an almost uniform distribution of about two cancerous lesions per mouse after 6 weeks, compared with approximately 14 tumors / mouse for those with Notch1 function still remaining.

«It wasn't known whether miR - 486 functioned as an oncogene or a tumor - suppressor gene in lung cancer,» says co-corresponding author Patrick Nana - Sinkam, MD, associate professor of medicine and a researcher with the OSUCCC — James Molecular Biology and Cancer Genetics Program.

Such genes are referred to as oncogenes.

A microRNA — a small piece of RNA involved in regulating gene expression — functions as an oncogene to drive the development of lung...