Sentences with phrase «cell transformation»
"Cell transformation" refers to the process in which a healthy cell changes into an abnormal cell. This change can lead to the development of diseases, such as cancer. Full definition
Understanding cell transformation can help clinical researchers tackle medical problems.
sciencedaily.com
As a result, they gained new understanding of how a substance known as transforming growth factor triggers cell transformations.
Furthermore; it was observed that introduction of exogenous glutamate receptor membranes 1 into melan - A cells resulted in cell transformation in vitro and robust tumor formation in vivo [44].
We have shown that telomere instability due to excessive shortening is the main driving force of chromosome aberrations during the early stages of cell transformation.
«It's also important to look not only at different tumor cell transformations but at all the cells in the tumor microenvironment, including these endothelial cells,» he says.
If researchers can control the processes directing stem cell transformation, they may one day be able to use these cells as a source of healthy replacement cells for diseased or injured tissues.
For example, cellular senescence is tumor suppressive and overcoming the senescence - associated cell growth arrest is a necessary step during cell transformation.
Understanding the effects of Eph receptor mutations in cancer cells will help shed light on the role of the Eph receptor / ephrin system in cancer cell transformation, malignant progression and drug resistance.
Karst AM, Jones PM, Vena N, Ligon AH, Liu JF, Hirsch MS, Etemadmoghadam D, Bowtell DD, Drapkin R: Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube - derived high - grade serous ovarian cancers.
The researchers also revealed that loss of Lsd1 in younger mice resulted in premature fat cell transformation.
However, the information acquired from regular two - dimensional culturing might not be directly applied to the process of cell transformation, which is typically assayed in three - dimensional conditions.
Inhibition of transcription (blockade of water) on tumor suppressor genes, such as p21, leads to cell transformation (growth of the cactus - like eremophytes instead of normal plants from the drought).