Sentences with phrase «circulating tumor cells»

Currently, in another study, the researchers are focused on detecting circulating tumor cells in the blood of patients with a diagnosis of breast cancer.

The first stage of the trial, which involved an analysis of circulating tumor cells from a single blood draw of several dozen patients, has demonstrated strong potential.

The study focuses on circulating tumor cells, a potentially rich source of information about a person's cancer.

For investigators studying circulating tumor cells, the next step after sampling is to isolate the desired cells as quickly and gently as possible.

The way in which they did this was by isolating circulating tumor cells from a drawing of blood.

For example, cancer cells floated above denser blood cells, which could allow clinicians to spot rare circulating tumor cells in a patient sample.

Anthony Lucci, M.D., professor of Breast Surgical Oncology and Surgical Oncology, is known for his work in using circulating tumor cells (CTCs) to detect early - stage breast cancer.

The team is currently working on genome sequencing of individual circulating tumor cells from patients at the Vancouver Prostate Centre.

«There was this initial thought that [circulating tumor cells] are only present at late stage,» says Sollier - Christen, but she notes that in the past year, several studies using more sensitive techniques have found such cells much earlier in tumor development, even before the tumor becomes visible by conventional imaging techniques.

The cells «have not been bound or squeezed, so they're really kept intact during the flow, and then [researchers] can just bring the [circulating tumor cells] to whatever platform they want to perform whatever assay they want,» says Sollier - Christen.

The NanoFlare technology is the first genetic - based approach that is able to detect live circulating tumor cells out of the complex matrix that is human blood — no easy feat.

In addition, while cfDNA correlated with tumor metabolism, no association was found with circulating tumor cells (CTCs).

Chicago, GenomeWeb — A new study by researchers from Memorial Sloan Kettering Cancer Center has demonstrated the predictive power of an AR - V7 protein expression test using Epic Sciences» non-EPCAM-based circulating tumor cell detection platform, which could help guide treatment decisions for men with metastatic castration - resistant prostate cancer.

Yet most tumor cells die before they can take root in the brain, which is better protected than most organs against colonization by circulating tumor cells.

«Circulating tumor cell clusters more likely to cause metastasis than single cells.»

Circulating tumor cells then exploit endothelial cell receptors in distal vascular beds to promote their arrest and retention in target organs (7).

The field segregates into three major strategies: detecting free nucleic acids, isolating intact circulating tumor cells, and identifying extracellular vesicles from tumors.

Cancer can still be deadly, even after surgery to remove the primary tumor because the cancer can metastasize in other parts of the body, and because circulating tumor cells can remain after surgery.

Because maraviroc blocks the actions of CCL5, it could be delivered, along with standard chemotherapy, right after surgically removing a tumor in a bid to prevent any leftover circulating tumor cells from finding a new metastatic niche in the body, Popel says.

Most circulating tumor cells may not metastasize, and analysis of the cancer cells could identify those that will.

Liu and his team recently improved upon the device's release efficiency — or its ability to allow circulating tumor cells to be collected for further study.

Liu has been perfecting a microfluidic device the size of two quarters that has the ability to catch and release circulating tumor cells (CTCs)-- cancer cells that circulate in a cancer patient's blood.

Cancer cells that migrate into the bloodstream are called circulating tumor cells (CTCs).

So my field is science and technology, so my work is circulating tumor cells where I isolate cancer cells from blood of patients and isolate their DNA and RNA and try to sequence them and try to device treatments for cancer treatment and therapy.

The American Gastroenterological Association featured Dr. Waxman's work in a blog post about circulating tumor cells (CTCs) in patients with pancreaticobiliary cancers.

Review Circulating Tumor Cells in the Parallel Invasion Model Supporting Early Metastasis Gerhard Hamilton, Barbara Rath Oncomedicine 2018; 3: 15 - 27.

DENVER — Three manuscripts published in the recent issue of the Journal of Thoracic Oncology, the official journal of the International Association for the Study of Lung Cancer (IASLC), explored the versatility of liquid biopsies by identifying EGFR mutations using circulating tumor DNA (ctDNA) in urine and plasma and examining circulating tumor cells (CTCs) in plasma to predict the risk of lung cancer recurrence after surgical resection.

«The idea of isolating a patient's own circulating tumor cells, assembling a microscopic copy of the tumor and creating an unlimited supply for on - the - spot drug testing is a real game changer,» says Dr. Simeone.

Additionally, she is investigating the role of circulating tumor cells expressing these checkpoint molecules.

The interaction between circulating tumor cells (CTC) and endothelial cells during extravasation is a critical process during metastatic colonization, but its mechanisms remain poorly characterized.

The herringbone pattern of interior surfaces in the HB - Chip brings more circulating tumor cells into contact with the antibody - coated capture surfaces.

Frouws» team believe the drug may boost the immune system's ability to detect and destroy circulating tumor cells in the blood.

Greece Test Circulating Tumor Cells are cells that have been released from a tumor and are circulating in the blood stream.

«The focus on capturing circulating tumor cells is quite new,» said Balaji Panchapakesan, associate professor of mechanical engineering at WPI and director of the Small Systems Laboratory.

The results were published in the journal Lab on a Chip (Lab on a Chip 17 (19), 3291 - 3299) in an article called: «Magnetic particles assisted capture and release of rare circulating tumor cells using wavy - herringbone structured microfluidic devices.»

Uncovers biomarkers and uses circulating tumor cells and circulating tumor - free DNA to predict responses to treatment

While many researchers are still developing affinity - based techniques for isolating circulating tumor cells, others are exploiting the physical differences between normal and tumor cells.

To better study circulating tumor cells, the researchers collaborated with physician - scientists and industry engineers to develop a microfluidics system that separates these large cells into a concentrated sample.

Now a team of researchers in China has developed a new microfluidic chip that can quickly and efficiently segregate and capture live circulating tumor cells (CTCs) from a patient's blood, with potential applications for cancer screenings and treatment assessments.

«We wanted to utilize platelets» intrinsic tendencies to accumulate at wounds and to interact with circulating tumor cells, for targeted delivery of immune checkpoint inhibitors» said Gu, «Interestingly, we found the antibody can be promoted to release from activated platelets in the surgical site, due to generation of small platelet - derived microparticles upon the platelet activation.

The technique, described in Biomaterials, uses gold nanoparticles and Raman scattering, a technology previously developed by Qian and Nie for cancer cell detection (2007 Nature Biotech paper, 2011 Cancer Research paper on circulating tumor cells).

Immunicon Corporation (PI)($ 40,000 Total) 2001 - 2002 Longitudinal enumeration of circulating tumor cells in patients with metastatic breast carcinoma

Berkeley researchers isolated circulating tumor cells from the blood of breast cancer patients, then used microscale physics to design a precision test for protein biomarkers, which are indicators of cancer.

«It adds to the portfolio of latest technology developments for separating such things as rare circulating tumor cells in the blood.»

Currently marketed for research use by Biofluidica, the test's microfluidic channels use specific cancer antibodies to detect capture circulating tumor cells.

The other two major targets in the field, circulating tumor cells and exosomes, come with their own challenges.

Newer work suggests that these circulating tumor cells may show up much earlier, but finding them then requires extremely sensitive assays.