Sentences with word «cytogenetics»

Research Technician in Human Molecular Cytogenetics at the Cambridge University Department of Pathology

Then, Scott contacted co-author Dr. Seema Lalani, associate professor of molecular and human Genetics at Baylor and assistant laboratory director of cytogenetics at Baylor Genetics.

Associate Director, Clinical Cytogenetics Laboratory, The Jackson Laboratory for Genomic Medicine

The AKC CHF - funded NC State CVM research projects are: Grant 1557: High - Resolution Cytogenetic Analysis of Histiocytic Malignancies and Development of a Targeted Assay

This facility offers conventional as well as molecular cytogenetic services including cell line authentication, species identification, karyotyping, analysis of genomic instability, fluorescence in situ hybridization and Spectral Karyotyping.

Approximately 20 % of AML patients have these mutations, which are more common in older patients, those with diploid or other intermediate - risk cytogenetics, sustained or higher platelet counts, and elevated bone marrow blast counts, Stone said.

«Even high - risk patients have close to a 70 percent chance of getting to what we call a complete cytogenetic response, which is an optimal response to the drug,» said Druker.

Director, The University of Chicago Comprehensive Cancer Center Director, Cancer Cytogenetics Laboratory Professor of Medicine, Section of Hematology / Oncology

The scientists, including Florian Reisinger from the Institute of Virology (HMGU) and Dr. Kristian Unger from the Research Unit Radiation Cytogenetics (HMGU) showed this using mouse models.

«The benefit was most evident in patients with uninformative cytogenetic or molecular markers who had negative MRD [minimal residual disease] at the end of induction I.»

After graduation, Cinthya moved to Harvard and the Brigham and Women's Hospital for postdoctoral work with Dr. Cynthia Morton, where she uses cytogenetics techniques to understand human diseases.

The other twelve were FAB type M1 with normal cytogenetics, where the initiating event is usually unclear.

[5][6] In agreement with the International System for Human Cytogenetic Nomenclature (ISCN), this chromosomal translocation is designated as t (9; 22)(q34; q11).

Lots of meetings supervising technicians, students, and post-docs in addition to other administrative meetings; lots of time at the computer answering e-mails and writing papers and grants; providing diagnostic cytogenetic services; editorial responsibilities for The American Journal of Human Genetics; relishing the privilege of being a scientist and especially a human geneticist!

He provides additional detail on whole chromosome versus molecular and biochemical genetic tests, including cytogenetic tests (karyotyping and fluorescent in situ hybridization (FISH) tests) and molecular tests.

In human medicine, the identity of cytogenetic aberrations has been shown to also assist in the localization of cancer - associated genes and even selection of the most appropriate therapeutic approach.

A large variety of methods is used including genetic, molecular and cytogenetic techniques, fluorescence in situ hybridisation and DNA «combing», as well as high throughput sequencing approaches such as DNA - seq for mutation landscape analyses, RNA - seq for transcriptome analyses and ChIP - seq mapping of chromatin - associated proteins and their genome - wide modulation in response to DNA damages.

Among patients with favorable cytogenetic and molecular features, the point estimates for disease - free survival and overall survival were approximately 1, indicating no benefit of a fifth course of chemotherapy, Getz said.

Our major resource development projects involve both data and biological resources for a variety of programs including the Mutant Mouse Resource and Research Center at JAX, the Special Mouse Strain Resource, the Mouse Mutant Resource and NICHD's Cytogenetic Models Resource.

This approach is now being used to derive embryonic stem cells from a variety of strains including disease models from which in vitro tools are in demand, including mouse models of Alzheimer's disease, cytogenetic disorders (Turner's syndrome and Down syndrome), and tool strains for systems genetics.

«And more importantly, we found that if a patient achieves a complete cytogenetic response, the risk of relapse is the same whether the patient was at low, medium, or high risk when diagnosed,» said Druker.

From cytogenetic research to genome - wide copy number association from micro-arrays, SVS delivers a powerful toolset for correlating common and rare chromosomal aberrations with disease.

Abstract: Characterizing de novo balanced cytogenetic abnormalities through sequencing in 147 subjects with multiple congenital abnormalities.

Grant 1557: High - Resolution Cytogenetic Analysis of Histiocytic Malignancies and Development of a Targeted Assay to Screen for Expression Level Changes Dr. Matthew Breen, PhD Project Goal: The goal of this project is to narrow down the search for genes playing a key role in Histiocytic Malignancies and thus move a step closer to developing targeted therapies for canine patients diagnosed with this devastating cancer.

Association of mutations with morphological dysplasia in de novo acute myeloid leukemia without 2016 WHO Classification - defined cytogenetic abnormalities

Age and cytogenetics as predictors of event free survival in patients with acute non-lymphocytic leukemia receiving high dose cytosine arabinoside and daunorubicin as consolidation chemotherapy.

The study was carried out by Sandra Rodriguez - Perales − from CNIO's Molecular Cytogenetics Group, led by Juan Cruz Cigudosa − and Juan Carlos Ramírez and Raúl Torres, from CNIC's Viral Vector Technical Unit.

It is the first study to find a molecular cytogenetic basis of EPSPS gene amplification in kochia.

Recent data published in the international journal Comparative Cytogenetics by Mauro Mandrioli, Federica Zanasi and Gian Carlo Manicardi of the University of Modena and Reggio Emilia (Italy) clearly showed that populations of the green peach aphid Myzus persicae (one of the most dangerous pest crop insects in the world) may have unusual karyotypes due to chromosomal fragmentations and / or rearrangements also within the same individual.

Clinical Cytogeneticists are certified to perform and interpret cytogenetic analyses such as karyotypes.

To provide state - of - the - art cytogenetic services, to perform basic research in human genetics and to serve the American Society of Human Genetics and greater scientific community through promoting the highest standards of scientific publishing.

Low risk was defined as patients with the presence of inv (16) / t (16; 16) or t (8; 21) cytogenetic features, NPM1 or CEBPA mutations, or MRD < 0.1 % post-induction I in those with no high - risk features.

The high resolution that is achieved by these techniques, particularly by microarray technologies such as array comparative genomic hybridization, is blurring the traditional distinction between cytogenetics and molecular biology.

Furthermore, whole - genome sequencing enables comprehensive genetic testing — from SNVs in known disease genes to large cytogenetic abnormalities — in a single assay.

Enzo Clinical Labs also provides clinical diagnostic services that allow Enzo to capitalize on its extensive advanced molecular and cytogenetic capabilities and the broader trends in predictive and personalized diagnostics.

Karyotyping of human NSC - derived iPS lines was performed at the Molecular Cytogenetics shared resource at the Ohio State University Comprehensive Cancer Center.

Insect behavioral ecology; plant - insect interactions; the evolution of cooperation, division of labor, and sex ratio; lepidopteran cytogenetics; chromosomal non-disjunction.

PSI Genetiscan cytogenetics workstation with dedicated EM 400 Nikon Microscope, CCD camera and karyotyping software

Obviously, these will include more AML samples, hopefully some with therapy - related changes or abnormal cytogenetics.

Characterization of balanced chromosomal rearrangements at the nucleotide level has led to translation of the methods into the clinic in the setting of prenatal diagnosis and to the development of a suggested next - gen cytogenetic nomenclature.