Sentences with phrase «gene interactions»

These findings thus provide initial evidence of a gene × gene interaction on conduct disorder and antisocial behavior in a sample of males.

In conclusion, our study highlights the importance of studying gene — gene interactions in complex diseases and provides insights into the underlying cellular and molecular mechanisms.

A new technique produces complex maps of gene interactions and how they change as cells mature.

In medicine in the future, doctors may be able to take advantage of complex gene interactions when they develop treatment plans.

Another set of researchers attempting to replicate this finding failed to detect a significant gene × gene interaction [11].

Which slows the accumulation of whatever drug - gene interaction evidence would be useful.

Common diseases turn out to be caused by intricate gene interactions, and genes respond to environmental signals in confusing ways.

The researchers next conducted a variety of brain mapping experiments to locate where in the brain these crucial seizure - gene interactions take place.

The brothers got the idea for the drug - gene interaction database after they repeatedly were asked whether lists of genes identified through cancer genome sequencing could be targeted with existing drugs.

Whether the gene × gene interaction would be detected later in life is an empirical question that subsequent research needs to investigate.

This highlights the importance of integrating gene — gene interactions in the genetic studies.

By the end of her talk, everyone understood how to use the tool for identifying complex gene interactions.

The researchers identified complex gene interaction involving three or more mutations for HIV; a malaria - causing parasite; the type of fungus that causes black mold on fruits and vegetables; and a family of genetic mutations that contribute to antibiotic resistance.

However, we know of no research that has reported a gene × gene interaction on a CD behavioral phenotype.

«There are different gene - gene interactions even though the flies are genetically the same, so that the female genetic background seems to become more protective.»

Conventional methods for identifying complex gene interactions rely on precise measurements of the genetic fitness of mutants.

They showed that NDP1 bioactivity governs key gene interactions decisive in cell survival when threatened by disease or injury.

Research led by Nicolas Bazan, MD, PhD, Boyd Professor, Ernest C. and Yvette C. Villere Chair of Retinal Degeneration Research, and Director of the Neuroscience Center of Excellence at LSU Health New Orleans, has discovered gene interactions that determine whether cells live or die in such conditions as age - related macular degeneration and ischemic stroke.

«Important gene interaction defined that drives aggressive brain cancer.»

Molecular analysis showed that heart cells in affected animals were poorly developed and had mitochondrial defects, indicating that Sap130 - Pcdha9 gene interactions play a crucial role not only in heart development but also in regulating metabolic function of the cardiac muscle.

Our BN analysis methods can be used to identify novel gene interactions and networks for advanced study of different biological networks and pathways.

The ImagineArray ™ is a ready - to - run platform with pre-printed experiments that can simultaneously edit or silence up to 3200 genes, which makes it ideal for straight - forward screening as well as advanced cell biology assays such as drug / gene interaction screens and synthetic lethality.

We have developed new BN algorithms and tools for analysis of gene interaction networks using high throughput gene expression data.

We use large - scale gene expression studies and phenotypic analyses in defined sets of mouse strains (so - called genetic reference populations) as well as sophisticated biomathematical tools to learn about how high - dimensional gene - gene interactions respond to the activity - dependent stimulus and affect the stem cells and developing new neurons.

Understanding gene interactions can enable breeders to break existing productivity barriers in agriculture...

Structure is controlled by genes that affect bones, muscles, tendons, ligaments, and growth rate, and health depends on gene interaction as simple as that governing progressive retinal atrophy (the dog either has it or he doesn't; there's no halfway) or as complex as that influencing various autoimmune diseases, seizures, or various circulatory defects.

It is likely that a secondary gene interaction occurs in the small percentage of dogs possessing the HC mutation but does not develop cataracts.

The results suggest that a gene × gene interaction between DRD2 and DRD4 is associated with the development of conduct disorder and adult antisocial behavior in males.

In order to reduce problems of collinearity, the main effect terms were mean centered prior to constructing the gene × gene interaction term [35].

Development of adulthood hostile attitudes: Childhood environment and serotonin receptor gene interactions.

A considerable genetic heterogeneity is expected within and among studies, as different combinations of the various alleles of the multiple genes and epistatic gene interactions may produce similar phenotypes.

It includes more than 14,000 drug - gene interactions involving 2,600 genes and 6,300 drugs that target those genes.

But there may be other, more deeply rooted, connections — tracing to an overlooked intersection of gene interactions or to another surprise crossing of molecular pathways.

Taken together, empirical evidence suggests that antisocial conduct constitutes a polygenic phenotype, with the effects of some polymorphisms conditioned by the possession of other polymorphisms — that is, a gene × gene interaction [3].

Dr. Rotimi's group has also developed tools that respond to the changing resources and challenges of the field as a whole: novel approaches for the simultaneous analysis of common and rare variants, approximate and exact tests of Hardy - Weinberg equilibrium using uncertain genotypes, and a test for gene - gene interactions in case - control studies.

Little empirical research, however, has been undertaken that examines gene × gene interactions in the etiology of conduct disorder and antisocial behavior.

This means one can see that one is dealing with a complex gene interaction,» Crona said.

Individual genomic info is being considered for drug prescription, but more info on drug - gene interactions is still needed.

«Cyberspace is the only place I could imagine that could hold the complexity of gene interaction that really describes an organism,» says Brody, who poured 6 months of 17 - hour days into the project.

The next step will be to optimize the approach and to extend it to protein - protein interactions, protein - gene interactions, disease - protein interactions, disease - drug interactions all with a view to improving diagnostics and tailoring therapy for the individual patient based on the outcomes of their personal biological network analysis.

Case studies described in the article show how microRNAs may affect voluntary alcohol consumption in mice, candidate genes within signaling pathways associated with chronic obstructive pulmonary disease, and the microRNA: gene interactions that influence bladder cancer.

But other genetic vatiants may be beneficial: On chromosome 8, another statistically significant diet - gene interaction was found in variant rs1269486.

«Estrogen alters memory circuit function in women with gene variant: Hormone - gene interaction may underlie sex / individual differences in mental disorders.»

While a handful of food - gene interactions have been studied before — lactose intolerance, for instance, is known to be caused by a variation in the lactase gene — most are only now being charted.

We also seek similar scaling up of the in vitro experiments, sampling deeper into the landscape of cancer genes, gene - gene interactions and combination drug responses.

«We suggest that such abundant and complex transcription may increase gene - gene interactions and constrains coding - sequence evolution.»

The higher complexity of the biochemical network in the brain, they suspect, with multiple gene - gene interactions, places strong constraints on the ability of most brain - related genes to change.

Gene - gene interactions and gene - environment interactions are being explored.

We integrate functional genomic datasets with up - to - date gene and genome annotations, Gene Ontology and pathway annotations, gene orthologs, gene interactions, and a comprehensive set of miRNA - target predictions for human, mouse, zebrafish, and nematode.