Sentences with phrase «gonadal hormones»

We analyzed risk for bone sarcoma using months of gonadal hormone exposure as a continuous variable.

Because the database used in that study provided no information on age at gonadectomy, the study could not evaluate bone sarcoma risk in terms of duration of gonadal hormone exposure.

The UC Davis study was undertaken, according to the researchers, because «Given the importance of gonadal hormones in growth and development, this cultural contrast invites an analysis of the multiple organ systems that may be adversely affected by neutering.»

To determine whether there was an association between endogenous sex hormones and risk of bone sarcoma, relative risk (RR) of incidence rates and hazard ratios for bone sarcoma were calculated for dogs subdivided on the basis of lifetime gonadal hormone exposure.

Although it remains unclear how endogenous gonadal hormones influence bone sarcoma development, the work provides the framework for selecting a target population for bone sarcoma prevention studies.

Little is known about how gonadal hormones or other host factors regulate sarcomagenesis.

Because neutering can be expected to disrupt the normal physiological developmental role of gonadal hormones on multiple organ systems, one can envision the occurrence of disease syndromes, including those listed below, to possibly be affected by neutering as a function of gender and the age at which neutering is performed.

If gonadal hormones alone control sex - specific brain function, the two halves of the bird's brain that controls song (known as the song circuit) would be uniformly masculine or feminine.

These findings suggest that variations in gonadal hormones during the menstrual cycle influence the experience of pain in healthy women.»)

Luboshitzky R, Levi M et al, «Long - term melatonin administration does not alter pituitary - gonadal hormone secretion in normal men,» Hum Reprod 2000 Jan; 15 (1): 60 - 5.

By the time a woman reaches menopause, gonadal hormone production, which has been on a slow, steady decline since her 30's, reaches its lowest point.

It is well understood that past sire and dam selection decisions within a breed alters gene frequency; disease expression patterns will be influenced by the interplay of altered gonadal hormones and the genetic background of the dogs [38, 39].

GnRH is an ideal contraceptive target because it regulates pituitary and gonadal hormone responses in both males and females, thus suppressing nuisance behaviors associated with sex hormones in addition to preventing pregnancy.

The possible mechanisms by which gonadal hormone exposure might protect against the development of bone sarcoma in both males and females are not immediately evident.

Overall, mean ± SD age at appendicular bone sarcoma diagnosis was 8.3 ± 1.9 years, which did not differ significantly between different gonadal hormone exposure categories.

However, in that study, age at neutering was not available, and thus, duration of exposure to gonadal hormones for each dog could not be determined.

To characterize the dose - response relationship between endogenous sex hormones and bone sarcoma risk, a study providing information on lifetime gonadal hormone exposure would be required.

While the study set out to estimate incidence rates of each disease related to age at neutering, patients were diagnosed at different ages and with differing durations of the disease as well as varying years at risk from the effects of gonadal hormone removal.

These subgroups included two biologically distinct groups representing the extremes of gonadal hormone exposure (i.e., dogs neutered before skeletal maturation at < 1 year of age and dogs that remained sexually intact for their entire lifetime).

Given the importance of gonadal hormones in growth and development, this cultural contrast invites an analysis of the multiple organ systems that may be adversely affected by neutering.

Prenatal Testosterone Exposure Leads to Gonadal Hormone - Dependent Hyperinsulinemia and Gonadal Hormone - Independent Glucose Intolerance in Adult Male Rat Offspring.

Cooke will receive the award over the next five years to study how rising levels of gonadal hormones, such as testosterone and estrogen, change behavior, motivation and perception during puberty.

Sex difference in hepatic peroxisome proliferator - activated receptor α expression: influence of pituitary and gonadal hormones

This is in agreement with findings in juvenile male and female rats with low levels of gonadal hormones.

Men more often developed fatty liver disease than females, due to more pronounced insulin resistance, different effects of gonadal hormones and environmental aspects (Figures 2 and 3).

Despite the many variations that our bodies can handle, significant and prolonged variations of gonadal hormones will cause an effect at target tissues.

Behavioural risks in male dogs with minimal lifetime exposure to gonadal hormones may complicate

Lifetime gonadal hormone exposure of each dog was expressed in terms of total months of gonadal hormone exposure (i.e., number of months sexually intact).

For females, the gonadal hormone exposure subgroups were: spayed before 1 year of age; spayed between 1 and 5 years of age; spayed after 5 years of age; and sexually intact.

McGreevy PD, Wilson B, Starling MJ, Serpell JA (2018) Behavioural risks in male dogs with minimal lifetime exposure to gonadal hormones may complicate population - control benefits of desexing.