Sentences with phrase «hematopoietic stem»
The phrase "hematopoietic stem" refers to a type of cell in our body that has the ability to develop into different types of blood cells. These stem cells can produce red blood cells, white blood cells, and platelets, which are important for various functions in our body, such as oxygen transport and immune response. Full definition
Devine SM, Hoffman R. Role of mesenchymal stem cells in hematopoietic stem cell transplantation.
cellr4.org
Despite promising results from animal studies, the viability of the cell transplantation paradigm in human has been demonstrated in only a few contexts, mainly involving the use of hematopoietic stem cell transplants, autologous skin and cartilage grafts, or the autologous recellularization of decellularized or engineered tissue.
Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self - renewal.
The treatment in the current study, called autologous hematopoietic stem cell transplantation (AHSCT), was given to patients with advanced forms of the disease that had failed to respond to other medications.
One promising solution to increase long - term overall survival has been in the area of allogeneic hematopoietic stem cell transplantation (HCST).
Tens of thousands of these procedures, often referred to as bone marrow transplants but more properly called hematopoietic stem cell transplants, are performed each year to rescue patients with immune system disorders or cancers.
They measured aging marker p16 on blood cells before and after of chemotherapy with hematopoietic stem cell transplantation.
Currently, only one CXCR4 antagonist, plerixafor, has been approved by the FDA for hematopoietic stem cell mobilization as an injectable agent for short - term treatments.
«Immunotherapy drug nearly eliminates severe acute graft - versus - host disease: Drug used to treat rheumatoid arthritis improves survival after hematopoietic stem cell transplant.»
For more on the different stem cell types, see a variety of previous Biology Bytes articles, including ones on hematopoietic stem cells, human embryonic stem cells, mesenchymal stem cells, endometrial regenerative cells, induced pluripotent stem cells, direct reprogramming, bioengineering organs, treating HIV with stem cells, Hans Keirstead, cancer stem cells, and cancer vaccines.
Results from a phase 2 clinical trial, presented by Seattle Children's Research Institute at the 59th American Society of Hematology (ASH) Annual Meeting, show that the drug Abatacept (Orencia) nearly eliminated life - threatening severe acute graft - versus - host disease (GvHD) in patients receiving hematopoietic stem cell transplants.
I work on the development of gene therapy using hematopoietic stem cells.
«A large number of quiescent hematopoietic stem cells was activated simultaneously when the epigenetic control provided by genomic imprinting was removed,» explains Venkatraman.
Somewhat sparsely described in the book is the vast clinical use of adult hematopoietic stem cells in autologous and allogeneic transplantation.
Since then he has continued to investigate new strategies to overcome the major hurdles to safe and effective gene transfer, translate then into new therapeutic strategies for genetic disease and cancer, and allowed new insights into hematopoietic stem cell function, induction of immunological tolerance and tumor angiogenesis.
Compared with the toxicity that we see with allogeneic donor hematopoietic stem cell therapy, these toxicities are relatively manageable with close monitoring and close supportive care.
A detailed comparison of gene expression signatures between ETP ALL tumors and and normal human hematopoietic progenitor cells revealed a somewhat surprising finding: ETP - ALL expression patterns were less consistent with early T - cell precursors, as might have been expected, but more similar to the expression profile of normal hematopoietic stem cells and granulocyte macrophage precursors.
Marie - Dominique Filippi, PhD, PhD Cincinnati Children's Hospital Medical Center Cincinnati, OH Mitochondrial Morphology Controls Hematopoietic Stem Cell Self - Renewal and Confers Them Divisional Memory
Targeted Gene Addition to a Safe Harbor locus in human CD34 + Hematopoietic Stem Cells for Correction of X-linked Chronic Granulomatous Disease.
Review of «Intercellular Transfer of Microvesicles from Young Mesenchymal Stromal Cells Rejuvenates Aged Murine Hematopoietic Stem Cells» from STEM CELLS by Stuart P. Atkinson
The researchers focused on how hematopoietic stem cells developed into one of two types of white blood cells: macrophages or neutrophils.
Zhao and his colleagues discovered that as a terminally differentiated progeny, megakaryocytes regulate hematopoietic stem cells by performing two previously unknown functions.
«We found that TRAF6 overexpression in mouse hematopoietic stem cells results in impaired blood cell formation and bone marrow failure,» said Starczynowski, a member of the Division of Experimental Hematology and Cancer Biology at Cincinnati Children's Hospital Medical Center.
Under his direction, plasmid DNA, CAR - T - cells, regulatory T - cells, engineered stem cell grafts and gene modified hematopoietic stem cell products have been manufactured and released for use in Phase I / II clinical trials.
Note that Advanced Cell Therapy does not include Hematopoietic Stem Cell Transplants (HSCT), unless the cells are more than minimally manipulated before they are administered.
The team injected the concentrated, corrected hematopoietic stem cells into young mice.
The idea is that the ablation will destroy any remnant of the cancer together with the healthy hematopoietic stem cells, and that donor's blood stem cells will populate the patient's marrow and regenerate the entire red and white blood cell repertoire from healthy cells.
A Phase 3 Open - Label Randomized Study of Quizartinib (AC220) Monotherapy Versus Salvage Chemotherapy in Subjects with FLT3 - ITD Positive Acute Myeloid Leukemia (AML) Refractory To or Relapsed After First - line Treatment With or Without Hematopoietic Stem Cell Transplantation (HSCT) Consolidation
To successfully treat genetic blood diseases like SCID, however, researchers first have to show that the scissor method works on the blood cell - producing hematopoietic stem cells — required for a lasting cure — which Kohn says «may be less susceptible to gene correction, and may be more fragile to treat.»
«The ability to control autoimmunity by autologous HSCT [hematopoietic stem cell transplantation] has been demonstrated in other treatment - refractory autoimmune conditions, including neurologic diseases.
Bone marrow transplants can cure types of leukemia and lymphoma because hematopoietic stem cells derived from the donor's bone marrow can develop into immune cells capable of killing the patient's tumor cells.
A major scientific puzzle has been how and why immature hematopoietic stem cells initially express genes that are characteristic of both cell lineages.
The boxed warning also includes an increased risk of death following hematopoietic stem cell transplantation.
An important model system for differentiation is hematopoiesis where a single hematopoietic stem cell gives rise to a large number of cell types (essentially the entire blood system) through a series of characterized intermediate progenitor cells.
Review of «Evaluating Interaction of Cord Blood Hematopoietic Stem Progenitor Cells with Functionally Integrated 3D microenvironments» from STEM CELLS Translational Medicine by Stuart P. Atkinson
Clonal expansion capacity defines two consecutive developmental stages of long term hematopoietic stem cells.
When undergoing treatment for leukemia many patients require hematopoietic stem cell (HSC) transplantation to replace the blood stem... Continue reading Mice pave the way to a cord blood transplant advance
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment.
In two studies reported in Nature in May, teams at Harvard University and Weill Cornell Medicine at Cornell University created hematopoietic stem cells (HSCs).
Microarray profiling using the Affymetrix Mouse Genome 430 2.0 array, defines sets of genes that are specific to bone marrow - derived hematopoietic stem cells and their different immunological progeny.
Exonuclease 1 is essential for maintaining genomic stability and the proliferative capacity of neural but not hematopoietic stem cells.
Not to bore you with the science, but it seems our bone marrow produces more hematopoietic stem cells — the ones that lead to white blood cells — during our peak years, though it is important to note that this doesn't protect us from injury or malnutrition, and it doesn't last.
Of particular interest are the flexible hematopoietic stem cells important in that initial transplant.
Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative disease.