Sentences with phrase «host cell»

A particularly efficient and deadly type of toxin punches holes in the membrane of host cells, and thereby kills them.

His research contributions have enhanced an understanding of how these viruses enter into host cells and cause organ - specific disease.

The virus is missing a critical gene — one of only eight genes that make up the virus genome — that makes a protein the virus needs to reproduce in host cells.

This binding antibody / virus complex more easily enters host cells, allowing the virus to copy itself at even higher levels.

The former causes uptake of viral genomes by host cells and leads to subsequent gene expression (25).

In addition, these data suggest that bacteria that survive within host cells contribute significantly to infectious disease pathology, and should be considered a potential source of drug resistance.

The vaccine works by blocking the ability of the viruses to bind to host cell receptors.

If this strategy fails, the virus will lose its ability to spread to new host cells and the infection will then be stopped.

This protein allows flu viruses to latch onto host cells.

However, fragments of viral DNA remain and are detected by the resting host cell.

Several host cell targets are needed for replication of influenza and many other viruses.

These agents are extremely good at inserting their genes into the DNA of host cells.

In order to replicate, viruses must find some way of getting their DNA into host cells.

It also helps to inhibit the ability of the virus to enter host cells.

Recent research has shown that these stand - ins react differently to antibodies against the virus and to host cell receptors.

«One of the important points to come out of this work is that it implies a complex of multiple chlamydial proteins that function together to regulate exit mechanisms from host cells,» the authors further explain.

Also, inapparent infections by iridescent viruses may involve a low density of IIV particles in infected host cells [46], so without sensitive techniques such as MSP, it is not surprising that infections in CCD bee colonies were previously missed.

These researchers previously reported that at least one set of host cell proteins, called kinases, can control bacterial growth.

Researchers from the Centers for Disease Control and Prevention (CDC) and their colleagues precisely mutated a protein called hemagglutinin (HA), which sits on the surface of a flu virus and plays a major role in infection by recognizing receptor proteins on host cells.

Mycoplasma compete with host cells for nutrients and can alter expression of receptors, ion channels, and growth factors resulting in changes to the cell line's growth and behavior.

That ability to swivel explains exactly how the polymerase uses host cell RNA to kick - start the production of viral proteins.

Through a new study that explores one aspect of how the virus hijacks host cell machinery to replicate itself, UNC Lineberger Comprehensive Cancer Center researchers have gained insight into the workings of a potential drug target for hepatitis C.

However, fragments of viral DNA accumulate and are detected by the resting host cell through the sentry protein IFI16.

Statins may also inhibit host cell invasion by S. aureus and enhance the ability of phagocytes to kill the bacterium.

TRIM5 is part of a group of antiviral genes called «restriction factors,» which have evolved to protect host cells from infection by viruses.

Mitochondria defend host cells during Toxoplasma infection Lena PernauUniversity of Padua, Italy 14 May 201804:15 pm Host: Arturo Zychlinsky, MPIIB, Berlin Location: Max Planck Institute for Infection Biology, Seminar room 1/2 - Campus Charité Mitte

In another study published this week the group investigated influenza pH1N1 virus - host cell interaction in detail and found that certain host function could be temporally inhibited with small molecule MK2206 to block influenza infection in cell culture.

Amyloid - β was able to bind carbohydrates on the surfaces of microbes, preventing the invaders from binding host cells.

Moreover, recent studies show that T. gondii can deliver effector proteins into cells that it does not invade [33], [34], and that these proteins can manipulate host cells without active parasite replication [35].

The study, available in Nature journal, shows the spike protein portion of a virus's fusion machinery invades host cells.

«Cardiac stem cells from heart disease patients may be harmful: Researchers discover molecular pathway involved in toxic interaction between host cells and immune system.»

Much is known about flu viruses, but little is understood about how they reproduce inside human host cells, spreading infection.

Two - pore channels control Ebola virus host cell entry and are drug targets for disease treatment

It is hard to believe that such a simply constructed organism could be so deadly; however, this virus has proved especially effective at infecting by rapidly dividing host cells such as intestinal cells, bone marrow cells, cells of the lymph system, and fetal cells.

However, many studies of bacterial infection rely upon death of the insect host, or actin cytoskeleton staining of specific host cells, at fixed end - points to look at infection or the mode of action of different bacterial toxins.

For instance, bacteria wrap themselves in host cell plasma membrane to avoid being flushed out by the blood flow.

In the new study, experiments with genetically modified C. trachomatis and host cell lines showed that a C. trachomatis protein found in the inclusion membrane, myosin regulatory complex subunit A (MrcA), interacts with the host proteins ITPR3 and STIM1.

d) Mechanisms of host cell actin remodeling.

Human cytomegalovirus IE1 protein elicits a type II interferon - like host cell response that depends on activated STAT1 but not interferon -?.

Some of these genes are involved in making the proteins encoded by the viral DNA and may make it easier for Mimivirus to co-opt host cell replication systems.

In order to understand and treat these illnesses, researchers need to decipher the molecular processes which allow the bacteria cells to dock onto the healthy host cells.

«Antiviral ingredients of Ci extracts target viral envelope proteins on infectious particles and prevent them from contacting host cells,» Brack - Werner explains.

Infected individuals however, are constantly exposed to granulin - like proteins secreted by flukes, which subsequently cause host cells to proliferate uncontrollably, leading to tumour growth.

By teasing apart the structure of an enzyme vital to the parasites that cause toxoplasmosis and malaria, Whitehead Institute scientists have identified a potentially «drugable» target that could prevent parasites from entering and exiting host cells.

It built on previous ground - breaking work on malaria published in 2011 by author Monash Professor Christian Doerig, and others, who found that if host cell protein kinases were prevented from working it would kill malaria parasites.

Prototype foamy virus protease activity is essential for intraparticle reverse transcription initiation but not absolutely required for uncoating upon host cell entry.