Here's a quick summary of the evidence supporting the use
of inositol supplements for metabolic health.
After first busting two of the most common myths deceptively touted by the supplements industry, I'm then going to share with you a comprehensive critical review of
inositol supplements for various different PCOS symptoms.
When
taking inositol supplements at these recommended levels, more is not necessarily better, and there doesn't appear to be any medical reason to favor one over the other.
Taking myo and d -
chiro inositol in a 40:1 ratio has been shown to improve egg quality and ovulation in women with PCOS in as little as three months, and may even work better than metformin.
Ive always been irregular and never know if or when I ovulate so not only am I wanting to take myo
inositol for that but to lose weight.
Research has found something fishy going on
with inositol in women with PCOS.
Adding
myo inositol along with melatonin, may improve fertility even more than with melatonin alone.
Effect of
inositol on bulimia nervosa and binge eating.
Iron chelators such as
inositol hexaphosphate (obtained from bran) serve to detoxify the mitochondria from iron - induced damage.
Chemoprevention supplements such
as Inositol hexaphosphate, and 1 -3-beta glucan may be recommend for the prevention of tumors reoccuring on dogs that are considered to be more predisposed.
Co-author, «Pathway for the Formation of D - 3 Phosphate
Containing Inositol Phospholipids in PDGF Stimulated NIH 3T3 Fibroblasts,» Biochemical Biophysical Research Communications, March 1991
The take home message from all of these details is that it's still very early days in the research into
using inositol supplements for the treatment of PCOS.
Because
inositol helps reduce insulin resistance, there will be less fat storage (insulin is a fat storage hormone) and improved blood lipids both equal a better chance at healthy and sustainable weight loss.
The animals lack the gene for an enzyme
called inositol hexakisphosphate kinase 1 (IP6K1), which is known to play a role in fat accumulation and insulin sensitivity.
Margaret found that taking
inositol powder with a small amount of melatonin about an hour before bed had a similar calming effect to Xanax, without the same side effects.
If you're still unsure, check out this chart comparing Ovasitol to
other inositol supplements on the market.
There are also other studies showing body weight is unaffected
by inositol supplements if you're a normal weight to start with (Genazzani et al. 20143) or you've been through menopause already (Santamaria et al. 20124).
Enhanced killing of androgen - independent prostate cancer cells using
inositol hexakisphosphate in combination with proteasome inhibitors.
Supplements used in breast cancer cases
include Inositol hexaphosphate and 1 -3-beta glucan.
A 2011 Italian double - blinded study confirmed that myo -
inositol decreases testosterone and increases insulin sensitivity, making it useful for the treatment of PCOS.
This ideal ratio has been shown to work better than myo or d - chiro
inositol alone.
I don't think I've seen
inositol added to dog foods previously so I had to look it up.
So far I've talked about
how inositol supplements can help us with the things that bug us the most when it comes to PCOS: weight loss, infertility, unwanted hair, and acne.
With this new understanding of the enzyme, called
Inositol trisphosphate 3 - kinase B (ItpkB), scientists are closer to improving therapies for diseases such as bone marrow failure syndrome, anemia, leukemia, lymphoma and immunodeficiencies.
Molecular genetics and bioinformatics.Analysis of
inositol metabolism in the model organism Drosophila melanogaster.
I was skeptical at first, but given the large amount of research I discovered
about inositol while writing the supplements chapter in PCOS: The Dietitian's Guide, I figured it was worth a try.
A plant based diet is also higher in
inositol which is present in grains, nuts and fruits and has been shown in one study to improve insulin function (Gerli et al, ERMPS 2003; 7:151 - 9).
Women with PCOS and acne may find that
inositol improves the clinical condition of skin by reducing levels of male hormones.
ALPHA LIPOIC ACID MELATONIN TEA TREE OIL B12 COLLOIDAL SILVER SPIRULINA
INOSITOL TAURINE CARVACROL - EX
When it comes to metabolic health, D - chiro -
inositol shows plenty of promise for women with PCOS that suffer from insulin resistance regardless of their bodyweight.
I have just
started inositol in the hopes that I can become pregnant hopefully soon.
Assessment of the modification of the clinical, endocrinal and metabolical profile of patients with PCOS syndrome treated with myo -
inositol].
Myo -
inositol administration positively effects ovulation induction and intrauterine insemination in patients with polycystic ovary syndrome: a prospective, controlled, randomized trial.
The
Myo inositol in pregnitude was shown in studies to reduce testosterone.
It's worth paying attention here to the fact that one of the most widely used myo -
inositol products also includes folic acid.
This article also considers safety and side effects and includes some helpful tips on how
much inositol to take for PCOS.
It seems
like inositol will be a major player in the future of PCOS treatment.
These forms of
inositol when taken together in a 40:1 ratio have been shown to reduce insulin, restore menstrual function and hormone balance in women with PCOS.
Research has already
found inositol to also have the following benefits in women with PCOS:
Combating the ovulatory disorders that lead to infertility is one of the areas
where inositol supplements show the most promise for women with PCOS.
A diet supplemented with pantothenate, choline, nicotinamide, histidine and
inositol significantly decreases trans - epidermal water loss in dogs The epidermis of the skin barrier is composed of two main parts, the cells or corneocytes and the intercellular lamellar lipid.