Sentences with phrase «kinase inhibitors»

Scanning electron micrograph of the coronary microvasculature of a mouse that has been treated with a small molecule tyrosine kinase inhibitor of platelet - derived growth factor receptor beta.

A number of kinase inhibitors in the clinic for the therapy of lung cancer have more than a single protein target.

In this theory it is explained that cutaneous melanoma occurs mainly due to DNA damage involving the region of cyclin dependent kinase inhibitor 2A gene (CDKN2A), as a result of exposure to excessive amounts of ultraviolet (UV) radiation from sunburn in early stages of life [25].

Gonzales AJ, Bowman JW, Fici GJ, Zhang M, Mann DW, Mitton - Fry M. Oclacitinib (APOQUEL ®) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy.

Cells were pretreated with kinase inhibitors for 1 h, followed by treatment with ActD for 6 h in HepG2 cells.

Complete remission with tyrosine kinase inhibitors in renal cell carcinoma.

Focusing on a particular group of enzyme - blocking compounds called protein kinase inhibitors, they identified 31 compounds that inhibit malaria growth without harming the host.

(Moussa is listed as an inventor on a patent application that Georgetown University filed related to nilotinib and the use of other tyrosine kinase inhibitors for the treatment of neurodegenerative diseases.)

First Veterinary Janus kinase Inhibitor Targets the Itch of Allergic Skin Conditions at Its Source

Rao B, van Leeuwen IM, Higgins M, Campbel J, Thompson AM, Lane DP and Lain S. Evaluation of an Actinomycin D / VX -680 aurora kinase inhibitor combination in p53 - based cyclotherapy.

Researchers found that genetically disrupting this pathway, or using the FDA - approved Src kinase inhibitor dasatinib, increases PUMA levels and decreases tumor progression and metastasis in mice by up to fivefold.

Rho - kinase inhibitor Y - 27632 (ROCKi) is a potential drug molecule, which has been reported to support the gene expressions typical for the chondrocytes, thus restricting their phenotypic conversion to fibroblastic cells upon the cellular expansion.

The adenosine triphosphate (ATP)-- competitive kinase inhibitors imatinib (STI571; trade name: Gleevec), dasatinib, and nilotinib inhibit multiple tyrosine kinases in addition to ABL1 and ABL2 (5).

DDRs inhibition with a tyrosine kinase inhibitor appears to insulate the brain via blood - brain barrier repair, which prevents harmful immune cells that circulate in the body from getting into the brain where they can indiscriminately attack and kill healthy and sick neurons, like those that have been unable to perform autophagy to «take out their trash,» says Moussa.

Moreover; mutations in cyclin - dependent kinase inhibitor 2A (CDKN2A) have been observed to be common among human cancers including melanoma.

A combination of the FLT3 kinase inhibitor quizartinib with 5 - azacitidine or low - dose cytarabine is active in patients with FLT3 - ITD mutated myeloid leukemias, according to a new study.

A combination of the FLT3 kinase inhibitor quizartinib with 5 - azacitidine (AZA) or low - dose cytarabine (LDAC) is active in patients with FLT3 - ITD mutated myeloid leukemias, according to a new study.

Updated findings from the pivotal phase II PACE trial show sustained benefit of the investigational BCR - ABL tyrosine kinase inhibitor ponatinib in heavily pretreated patients with resistant or intolerant chronic myeloid leukemia or Philadelphia chromosome - positive acute lymphoblastic leukemia.

None of the applied kinase inhibitors themselves distinctly induced p53 expression (Fig. 3D).

The addition of the Rho - associated kinase inhibitor [20] prior to and during the sorting procedure enable the analysis of the fate of single cells by a colony formation assay.

Overall, the results from oral kinase inhibitors are very exciting, says Robinson.

Vemurafenib joins other multi-targeted kinase inhibitors (MKIs)(sorafenib, lenvatinib) shown to be effective in this patient population; in spite of responses to these drugs, the responses are temporary and additional treatment options are needed.

His research focuses on understanding the biological underpinnings of sensitivity and resistance to specific kinase inhibitor targeted therapies in cancers with specific genetic abnormalities.

Rho - kinase inhibitor treatment increased the cellular proliferation up to twofold during the first 12 h, and a wound model based migration assay showed 50 % faster filling of the mechanically generated wound area.

In this study, we focused on pancreatic NETs (pNETs) and thought that treatment of these tumors upon progression on rapalog therapy, with an mTOR kinase inhibitor (mTORKi), could overcome a number of resistance mechanisms in tumors and delay cardiac carcinoid disease.»

Meanwhile, Incyte, a pharmaceutical company in Wilmington, Del., presented promising results from a smaller trial of its own kinase inhibitor.

«Our findings suggest that combination therapies with highly potent, brain - penetrant kinase inhibitors will be required to improve patient outcomes,» the study concludes.

Pao was involved in studies of EGFR tyrosine - kinase inhibitors while at MSKCC, where he trained in medical oncology.

The next step for CNIO, which has been running a drug - discovery program since 2005, would be to look for c - RAF kinase inhibitors as potential cancer drugs.

PKIS2 is a collection of more than 500 kinase inhibitors donated by GSK, Pfizer and Takeda Pharmaceuticals that SGC - UNC makes available to the scientific community.

THE STUDIES A trilogy of papers published in the September 28 issue of Nature examine the role of a protein — cyclin - dependent kinase inhibitor p16INK4a — in aging, healing, and cancer.

«Through our collaboration with DiscoverX, we screened a large set of compounds that we call Published Kinase Inhibitor Set 2, and these results allowed us to reach the halfway point in constructing the KCGS» said David Drewry, a research associate professor at the UNC Eshelman School of Pharmacy and SGC - UNC principal investigator who is leading the project to develop the Kinase Chemogenomic Set.

An international research group has now shown that there is another, equally effective oral treatment option: the combination of methotrexate and the chemically synthesised Janus Kinase Inhibitor tofacitinib.

«They also suggest that interactions between oncologic kinases and SYK or other wild type enzymes may contribute to resistance of kinase inhibitors more broadly.»

As the name suggests, kinase inhibitors interrupt the function of kinases — a particular type of enzyme — and effectively shut down the activity of proteins that contribute to cancer.

Many kinase inhibitors possess axes of chirality that are freely spinning.

In practice, this means that when medicinal chemists discover a promising kinase inhibitor that exists as two interchanging arrangements, they actually have two different inhibitors.

Researchers have previously injected p38 MAP kinase inhibitors into arthritic tissues to control pain and inflammation in animals with some success, but the new work indicates that injecting it into the central nervous system may be more effective, he says.

In the first study, in patients with active PsA who had not previously been prescribed an anti-TNF treatment, tofacitinib (an oral Janus kinase inhibitor under investigation for the treatment of PsA), was superior to placebo in ACR20 response rates and change from baseline in the HAQ - DI score at 3 months.

These data reveal that the tissue damage present in this SIRS model is reflected, in part, by breaks in the vasculature due to endothelial cell necroptosis and thereby predict that RIPK1 kinase inhibitors may provide clinical benefit to shock and / or sepsis patients.

Dr. Iavarone is currently establishing a cooperative study group, including CUMC and other brain tumor centers around the country, to conduct the trials of FGFR kinase inhibitors.