Sentences with word «kinesin»

Protein friction limits diffusive and directed movements of kinesin motors on microtubules.

His lab provided the first molecular descriptions of kinesin structure and organization, and has recently discovered important links between transport processes and diseases such as Alzheimer's disease and Huntington's disease.

«Cell division: Physical forces involved in creating the mitotic spindle probed: The motor protein kinesin - 5 appears to help organize spindle's filaments by pushing or slowing them.»

Cellular motors called kinesins drag cargo within cells — they tug recently separated chromosomes to opposite ends of a dividing cell, for example.

The worm - like structures are microtubules driven by kinesin motor proteins.

Secondary structure and compliance of a predicted flexible domain in kinesin - 1 necessary for cooperation of motors.

Till Korten (Diez, MPG)-- «How Kinesin - 1 deals with roadblocks: biophysical description and nanotechnological application» (2009)

The models showed kinesins, a family of motor molecules discovered in 1985, are «weakly susceptible» to small or medium external forces and pull their cargo through all but very strong opposition.

When that is the case, the lead kinesin carries more than 90 percent of the load.

Among the weak forces are those applied by trailing kinesins attached to the same cargo.

That's one conclusion from a Rice University - led study of the mechanisms that drive kinesins, motor proteins that carry cargo inside cells.

An illustration shows two load - bearing kinesins as they carry cargo along a microtubule (cyan).

The base simulation will allow researchers to test more kinesins that move cargo from the nucleus to the outer limits of the cell and, eventually, dyneins, larger and more complex proteins that move cargo toward the center.

The investigators showed that kinesin movement corresponds to traffic from the center of a nerve cell to its axonal tips — and a different motor in the squid's cytoplasm, which was subsequently identified as dynein, travels in the opposite direction.

This sliding was mediated by the minus end — directed kinesin motor Klp2, which helped microtubules to become properly organized with plus ends predominantly oriented toward the cell ends and minus ends toward the cell center.

Although scientists have found dozens of different kinesins, each with its own job, they know little about how the minimotors work.

Motor molecules called kinesins proceed along the protofilament, stepping from one dimer to the next.

A compound, adociasulfate - 2, was isolated from a marine sponge, Haliclona (also known asAdocia) species, that inhibited kinesin activity by targeting its motor domain and mimicking the activity of the microtubule.

This interaction nudges Kinesin - 14 backward, prompting it to guide the growth of the new microtubule in parallel with the older one.

Defective or deficient kinesins are implicated in Charcot - Marie - Tooth disease and some kidney diseases.

«Cell biology: Kinesins ignore weak forces as they carry heavy loads: How motor proteins cooperate — or don't — to transport cargo in cells.»

The study shows it takes a lot of counterforce to slow down a determined kinesin.

Kinesins transform energy from the chemical ATP, or adenosine triphosphate, into mechanical action.

As many kinesin - 5 molecules work together directing microtubules, they become the governing force of the spindle formation.

It turns out these teammates barely register to the boss kinesin if they are more than 48 nanometers away.

The study suggests that the collective behavior of motor proteins like kinesins keeps cellular transport systems robust by favoring slow and steady over maximum movement.

Drugs that could target kinesin - 5 more precisely by binding the newly identified pockets would be a big advance, he said.

«In nature, they work in teams, but because the motors respond relatively weakly to a significant range of forces, we argue this is the main reason kinesins do not always cooperate with each other.»

Rene Schneider (Diez, MPG)-- «A novel parabolic prism - type TIR microscope to study gold nanoparticle - loaded kinesin - 1 motors with nanometer precision» (2013)

The human kinesin - 14 HSET tracks the tips of growing microtubules in vitro.

A genomic toolkit to investigate kinesin and myosin motor function in cells.

Vladimir Varga (Howard, MPG)-- «Characterization of Saccharomyces cerevisiae kinesin - 8 by single - molecule fluorescene microscopy» (2008)

Fluorescence imaging of single Kinesin motors on immobilized microtubules.