Sentences with phrase «medicinal chemistry»
Medicinal chemistry refers to the field of science that focuses on creating and developing new drugs to improve human health. It involves studying how different chemical molecules interact with the body, with the aim of finding substances that can be used to treat diseases and improve medical treatments. Full definition
This process of medicinal chemistry is a long and slow one, but having skilled people who can help with this is absolutely essential in the drug discovery and development process.
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After several presentations about the history of the company and its record in medicinal chemistry, we were guided around the site.
After the initial screening, potential «hits» were optimized by medicinal chemistry and tested for potency, specificity, and toxicity.
You should have a passion for medicinal chemistry and enjoy and excel at making molecules using modern methods of organic synthesis.
«The cortex basically takes all the information coming in and synthesizes it into reality,» says David E. Nichols, a professor of medicinal chemistry at Purdue University in West Lafayette, Indiana, who has done animal research on hallucinogens.
Taken together, these data suggest that indole derivatives, although their IC50 values are in the micromolar range, represent functional leads for further development of novel CXCR4 antagonists useful in medicinal chemistry programs.
In a pharmaceutical patent case, this would involve studying medicinal chemistry and pharmacology in considerable detail.
Jahns fell into medicinal chemistry early in his academic career, after seeing how small molecules could affect biological systems.
Dr. Wei Zhu is currently a principal scientist at medicinal chemistry department, Roche Innovation Center Shanghai.
Sylvie Garneau - Tsodikova's research aims to understand and combat bacterial and fungal resistance by using tools from medicinal chemistry, biochemistry, microbiology, and structural biology.
Cosford had been investigating ULK1 using medicinal chemistry and chemical biology, and had identified some promising lead compounds using rational design.
«Modifications of the treatment regimens, additional optimization of the delivery methods via the use of hydrogels, and structural modifications of the compounds via medicinal chemistry could ensure even better results with CDK2 inhibitors in treating hearing loss in humans.»
His multidisciplinary academic research spans computer modeling, protein - protein / protein - ligand structural analyses, drug design, and synthetic medicinal chemistry, incorporating the principles of chemogenomics.
In addition to Abbott and his medical school colleagues, the research team included representatives of Oncodesign, a therapeutic molecule biotechnology company in Dijon, France; Janssen Research & Development, a New Jersey - based pharmaceutical company; andAsclepia Outsourcing Solutions, a Belgium - based medicinal chemistry company.
He is comfortable discussing medicinal chemistry, toxicology, drug safety and response, and, of course, genetics.
Some recent additions include: in 2007 GlaxoSmithKline opened a US$ 13 million medicinal chemistry outfit at Biopolis that doubled the company's research staff in Singapore; Eli Lilly's Singapore Center for Drug Discovery plans to boost its drug - discovery efforts, in part, by tripling its research and development staff to 150 within three years; the Novartis Institute for Tropical Diseases has grown to a staff of over one hundred researchers and supporting staff since its inception in 2002.
«For 20 years we have been using rational bioengineering to modify the chemical structures of clinically important natural products — using genetics to make a new molecule in a process that parallels medicinal chemistry — and that's what we were doing when we stumbled upon this,» said Professor Barrie Wilkinson from the John Innes Centre.
A postgraduate medicinal chemistry course has been proposed at the National University of Singapore that will aim to help meet an anticipated increase in demand for chemists.
«These CF3 groups have long been known as medicinal chemistry boons, but they were traditionally very difficult to install,» he added.
His research interests include medicinal chemistry, nanotechnology, drug delivery, cell trafficking and molecular imaging for theranostic applications in cancer and Alzheimer's disease (AD).
The Cosford lab employs medicinal chemistry and chemical biology approaches to probe cellular pathways that regulate cell survival pathways in deadly tumors.
At the moment, I don't think anyone has much of an idea on how to identify good small molecule candidates with conventional medicinal chemistry methods (though I'm intrigued to hear that you have some thoughts, AH!).
«To turn them into real therapeutics for testing, we will now optimize their properties through medicinal chemistry, so they are stable in the body, enter the brain, and safely engage the correct target in this fragile organ.»
After some classical medicinal chemistry, they arrived at the clinical candidate, verubecestat.
Another study published a mini perspective in the Journal of Medicinal Chemistry on «The essential medicinal chemistry of curcumin» (26).
Diverse medicinal chemistry background across multiple therapeutic areas, including infectious disease, neuroscience, cardiovascular, and cancer.
Synthetic organic chemist with extensive medicinal chemistry research experience in the pharmaceutical industry.
Suppliers sometimes pass off cheaper defrosted meat as fresh, according to Laurie Hall, professor of medicinal chemistry at the University of Cambridge.
John L. Neumeyer, PhD, received his BS from Columbia University, and PhD in medicinal chemistry from the University of Wisconsin, Madison.
For example, virtually every Pharmaceutical company's medicinal chemistry department now utilises NMR as a tool to verify the structure of small molecule compounds.
«Companies have amassed large — and in some cases very high quality — compound libraries,» says Lee Flippin, senior director of medicinal chemistry at FibroGen.
Promising compounds are being generated using established high throughput screening by medicinal chemistry and are being tested in preclinical animal models.
Rice wanted someone with Bowen's experience in medicinal chemistry and pharmacology.
Team leader Jonathan Dimmock, a medicinal chemistry researcher in the U of S College of Pharmacy and Nutrition, explained their compounds work by interacting with thiols, naturally occurring chemicals that perform several roles in cells.
Focus on courses that provide you with broadly applicable tools: information technology, informatics, drug development, clinical trials, medicinal chemistry, operations management, and regulatory affairs are obvious choices.
«With the growth of our small - molecule program we are looking for chemists with analytical methods development, synthetic organic, medicinal chemistry, and peptide chemistry expertise,» says Holly Butler, Genentech's principal staffing consultant for research.
This includes scientists working in analytical development, biology, formulations, medicinal chemistry, and so on.
David Rees, senior vice president of medicinal chemistry at Astex Therapeutics, a fragment - based drug discovery specialist based in Cambridge, keeps a keen eye on the recruitment market in the city.
«The bactericidal mechanism of ODLs and the fact that they bind to a site on the ribosome not exploited by any known antibiotic are very strong indicators that ODLs have the potential to treat infections that are unresponsive to other antibiotics,» said Mankin, who is also professor of medicinal chemistry and pharmacognosy.
A combination of techniques — from computation to medicinal chemistry — helps scientists pick better drug targets, often because of gaining a better understanding of how diseases work
«We're not only about discovery science but also translation science from which we can derive benefits for mankind,» explains Mark von Itzstein, executive director of the Institute for Glycomics and professor of medicinal chemistry and federation fellow at GriffithUniversity.
«We've rationally designed something to target multiple pathways, which is contrary to the traditional thinking in medicinal chemistry, where you have one target, one drug,» said University of Illinois chemistry professor Steven Zimmerman, who led the research with graduate students Lien Nguyen and Long Luu.
After earning a pharmacy degree in India, he moved into graduate studies in synthetic and medicinal chemistry at the University of Georgia.
Biology, microbiology / human genetics, medicinal chemistry, mechanical engineering / robotics, molecular & cell biology, computer science
Researchers led by Judy Bolton, professor and head of medicinal chemistry and pharmacognosy in the UIC College of Pharmacy, applied hops extract to two different breast cell lines to see if they would affect estrogen metabolism, a key mechanism in breast cancer.
Douglas Thomas, associate professor of medicinal chemistry and pharmacognosy at UIC, and co-workers discovered that nitric oxide plays an important role in epigenetics — heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence.