Sentences with word «microbicide»

Sharon Hillier and Ian McGowan of the U.S. - based Microbicide Trials Network, which ran the NIH - funded study of PRO 2000, said in a release issued today that the new results «raise little doubt that at this juncture, agents with specific action against HIV, such as antiretroviral drugs, offer the most hope.»

«This [set of studies] was the last hope for microbicides in many ways,» says Thomas Hope of Northwestern University's Feinberg School of Medicine in Chicago, Illinois.

Where budgets are limited, they suggest money should be allocated first to increasing male circumcision, then to more frequent HIV screening, use of vaginal microbicides and increasing antiretroviral therapy.

McCormack says the data mark the end of the road not just for this vaginal gel but the whole class of microbicides that use nonspecific compounds to prevent HIV - infection.

Scientists working in the field of herpes research have been exploring the possibilities of using Microbicides as a potential agent in the treatment of genital herpes.

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«Because SEVI can so greatly enhance HIV infectivity, supplementing current HIV microbicide candidates with SEVI inhibitors, such as surfen, might increase their potency and overall effectiveness,» Greene explained.

«I don't think anyone suspected that the tenofovir gel would not work,» says immunologist John Moore, who works on microbicides at Weill Cornell Medical College in New York City.

That $ 90 million study, financed by the U.S. National Institutes of Health (NIH), startled many in the field who, based on other failures of nonspecific microbicides, had predicted the product would do nothing.

A series of vaccine and microbicide clinical trials to prevent HIV transmission have been unsuccessful, and scientists are returning to the drawing board to devise new approaches.

Researchers leading a large, ongoing study in women called VOICE that compares PrEP with pills to a vaginal microbicide plan to revaluate the ethics of continuing to use a placebo control group given the new evidence of oral Truvada's powerful impact.

Pilar received her PhD in 2017 at the Complutense University of Madrid, where she studied immune cell dysfunction and hyperactivation in HIV / HCV coinfected patients, as well as the in vitro and in vivo activity of nanoparticles against HIV - 1 and HSV - 2 infections to prevent their transmission in humans as a topical microbicide.

International Rectal Microbicide Advocates (IRMA)(click on the link on this website to join) While IRMA offers a range of materials on their website, and they offer conference calls to discuss current topics in HIV prevention, one of their most dynamic features is an e-mail discussion list.

Salim Karim, an epidemiologist at the University of KwaZulu - Natal in Durban, South Africa, who co-ran a vaginal microbicide study that showed in July 2010 the first positive results with PrEP, said these «amazing results» are «set to revolutionize HIV prevention.»

The failure of first - generation microbicides has led the field to largely abandon the strategy behind them: that HIV could be stopped by compounds, such as soaps, that disable the virus without specifically attacking it.

Success of a vaginal microbicide gel reveals how HIV - prevention strategies can emerge from progress in treatment

Another application could be their development into crèmes or gels (i.e. microbicides) that prevent transmission of viruses like HIV during sexual intercourse.

A LIVING microbicide reduces HIV - like infection in monkeys, and might one day provide women with long - lasting defence against the virus.

Nonspecific anti-HIV microbicides — applied as a gel using this device — are not going to work, researchers say.

HIV blocking microbicides go on trial.

When the gel comes in contact with semen, the change in pH causes it to reliquefy and release an HIV - killing microbicide.

Other studies that will soon begin test whether less user - dependent delivery methods — such as a vaginal ring that dispenses an antiretroviral for a month at a time — will lead to more effective microbicides.

Today, most microbicides in human studies or on the drawing board contain anti-HIV drugs that cripple a critical viral enzyme.

Rhesus macaques like this one blocked the monkey version of HIV with a new microbicide.

Among other grants, he has participated to several EC - FP6 funded grants (AVIP, NEAT, Europrise) and coordinated the «GISHEAL» program on the genetics and immunology of HIV long term nonprogressors; he has also participated to the FP7 - funded project «AIM - HIV» on microbicide discovery.

The ongoing Cape Town congress is itself a sign of change, aimed at bringing together researchers pursuing their different aims in vaccines, pre-exposure prophylaxis, and microbicides along with community members, policymakers, and advocates.

James Eghaghe The New HIV Vaccine and Microbicide Research Advocacy Society of Nigeria (NHVMAS), Nigeria

Interim data from a parallel open - label study of the ring called HOPE, led by the US National Institutes of Health - funded Microbicide Trials Network (MTN), reported nearly identical results today at CROI.

«For example, we might be able to create combination microbicides that include agents targeting both the virus and host factors promoting infection.

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Researchers from the University of Nebraska - Lincoln have generated an «on - off switch» into a weakened form of HIV, potentially creating a new vaccine for Comprehensive exploration of research into HIV prevention, including microbicides, PrEP, PEP, condoms, circumcision and HIV treatment as prevention.

HIV Prevention Trials Network (HPTN) International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) Microbicides Trials Network (MTN)

Anderson chides fellow researchers for not using cell - associated HIV in their transmission models: «The failure of several recent vaccine and microbicide clinical trials to prevent HIV transmission may be due in part to this oversight.»

Unlike soap - based microbicides, GML is not a so - called surfactant that aims to disrupt the viral membrane, says Haase.

Their focus is on therapeutics for novel viral targets not inhibited by current therapies and topical microbicides, which could neutralize the virus prior to infection.

While they have a focus on rectal microbicides, the conversations are broad and include a full range of HIV prevention topics, LGBT rights around the world, and other related human rights and social justice topics.

Yet as a team led by Ashley Haase of the University of Minnesota, Minneapolis, found, a nonspecific microbicide that targets the vaginal immune responses works remarkably well in monkeys.

These include voluntary male circumcision — now recommended by the World Health Organization and Joint United Nations Programme on HIV / AIDS as a preventive strategy — as well as vaginal microbicides and oral pre-exposure prophylaxis, all of which confer only partial protection against HIV.