Sentences with phrase «muscle stem cells»

The novelty of this technique is that it generates a larger number of muscle stem cells without using genetic modification, which is required by existing methods for making muscle cells.

It is well established that both genes are needed to produce muscle stem cells in the embryo.

A genetic approach in the mouse has been used to examine how skeletal muscle stem cells are born, and how they acquire their identity.

I thought that if they are so important in the embryo, they must be important for adult muscle stem cells.

A key issue we address is the tissue environment in which muscle stem cells are activated.

The scientist believe that these two embryonic muscle stem cell genes also tell the stem cells to become quiet as the organism matures.

The scientists are eager to find these adult muscle stem cell genes.

The technique also creates a sustainable pool of muscle stem cells needed to support multiple rounds of muscle repair.

Two recent studies published in Diabetes and Scientific Reports highlight the loss of muscle stem cells early on in the disease; a likely key to the muscle deterioration which happens later on.

It turned out that these embryonic genes are important to muscle stem cell creation up to the first three weeks after birth.

The researchers then looked at whether the same was true upon injury, after which the repair process requires muscle stem cells to make new muscles.

Using genetic tricks, I was able to suppress both genes in the adult muscle stem cells.

Baltimore, MD — Scientists working at the Carnegie Institution's Department of Embryology, with colleagues, have overturned previous research that identified critical genes for making muscle stem cells.

Cajsa Davegårdh then compared the differences in DNA methylation in muscle stem cells from obese individuals (BMI over 30) and individuals of normal weight.

Using mouse skeletal muscle stem cells as a model, we show that accumulating transcripts specifying the myogenic program are not translated in quiescent satellite cells, but are repressed by the action of microRNAs and RNA binding proteins.

Following the generation of iMPCs by induced Pax7 overexpression in hPSC - derived mesoderm cells, Rao et al. employed two - dimensional (2D) conditions to generate a monolayer culture containing two essential components of skeletal muscle tissue: spontaneously contracting multinucleated myotubes and Pax7 expressing muscle stem cell - like cells.

To discover the next steps on the way forward for this exciting breakthrough for muscle stem cell research, stay tuned to the Stem Cells Portal!

Several growth factors, cytokines, and chemicals have been used in muscle stem cell cultures, but the optimal culture conditions required to maintain the undifferentiated state, inhibit differentiation, and enhance eventual transplantation efficiency have not yet been established.

They also looked for genes not previously studied for having a role in fusing muscle stem cells.

This process is also important in adult life because muscle stem cells fuse with existing fibers to achieve muscle growth and help regenerate damaged muscles.

More than a decade ago, Discover covered the concept of a coffee - maker - like device that could, overnight, turn a few animal muscle stem cells into a nice hunk of meat.

Previous studies have shown that two genes Pax3 and Pax7, are essential for making the embryonic and neonatal muscle stem cells in the mouse.

Researchers discover that the inhibition of a lysine methyltransferase allows for the long - culture and amplification of human muscle stem cells

«New method to grow and transplant muscle stem cells holds promise for treatment of muscular dystrophy.»

Last December, for instance, Chien's group reported finding markers for heart muscle stem cells by tracing their development from embryonic tissue.

Abstract Regeneration of the adult skeletal muscle tissue relies on a pool of quiescent muscle stem cells located in a niche around the myofibers: the satellite cells (MuSCs).

In the same way, whereas NR supplementation increased muscle stem cell number in aged mice, thereby enhancing mitochondrial function and muscle strength, it reduced the expression of cell senescence and apoptosis markers [233]; the state of senescence is important to protect against carcinogenesis [234].

A detour on the road to regenerative medicine for people with muscular disorders is figuring out how to coax muscle stem cells to fuse together and form functioning skeletal muscle tissues.

Led by researchers at the Cincinnati Children's Hospital Medical Center Heart Institute, the study demonstrates the gene Gm7325 and its protein — which the scientists named «myomerger» — prompt muscle stem cells to fuse and develop skeletal muscles the body needs to move and survive.

This summer Wagers published research [subscription required] showing that when muscle stem cells were transferred into mice with a type of muscular dystrophy, the rodents» muscle function improved.

The investigators found that when LIF - treated muscle stem cells were transplanted to skeletal muscle, they formed two to three times more muscle fibers as control cells did.

While transplantation of such muscle stem cells can be a potent therapy for degenerative muscle diseases such as Duchenne muscular dystrophy, these cells tend to lose their transplantation efficiency when cultured in vitro.

«These progenitor cells resemble adult muscle stem cells called «satellite cells» that can theoretically grow an entire muscle starting from a single cell.»

Human muscle cells assemble to form aligned, multinucleated (purple) muscle fibers and resident muscle stem cells (white).

The team could isolate muscle stem cells from the male mice before they died and when they transplanted them into muscle - damaged recipient mice, they found that the stem cells were able to regenerate new muscle.

The study, published in Nature Medicine on November 16, 2015, is the first to show that Duchenne muscular dystrophy directly affects muscle stem cells.

They also discovered that dystrophin is a key member of the molecular machinery that enables muscle stem cells sense their orientation in the surrounding tissue.

Research initiatives in his laboratory include analysis of the interaction between host immune factors (e.g., macrophages) and muscle stem cell remodeling during HIV - associated muscle wasting, and the molecular phenotyping of aging and identification of biomarkers for anabolic response.

Experimental approaches such as gene therapy are also being investigated, but Dr. Rudnicki's research suggests that these approaches will have to be modified so that they target muscle stem cells as well as muscle fibres.

But that idea was confusing to many because GDF11 is very similar to the protein myostatin, which prevents muscle stem cells from differentiating into mature muscle — the opposite effect to that seen by Wagers and her team.

In work published today in Cell Reports, scientists describe why fetal muscle stem cells (MuSCs) are better at regenerating muscle compared to adult MuSCs.

«Teaching stem cells to build muscle: New research shows young muscle stem cells can improve adult muscle regeneration.»

«Obesity reprograms muscle stem cells.»

These endogenous muscle stem cells promote regeneration of skeletal muscles after injury and that participate in adaptation to exercise.

The group now shows that female muscle stem cells are indeed better at regenerating diseased muscle in a mouse model.

In the present seminar, I will summarize our findings concerning the role of Srf in myofibers to control muscle mass and I will present recent data identifying Srf as a master regulator of muscle stem cell fusion and demonstrating the implication of F - actin architecture in this process.

In particular, I will focus on the role for the antagonism between various transcription factors and epigenetic enzymes in controlling the commitment of muscle stem cells towards alternate cell fates.